Cited by The cell autonomous and non-autonomous roles of itaconate in immune response

Dying to survive: harnessing inflammatory cell death for better immunotherapy DOI

Long Cheng, Yibo Wang, Ying Zhang

и другие.

Trends in cancer, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

In vivo itaconate tracing reveals degradation pathway and turnover kinetics DOI

Hanna Friederike Willenbockel,

Alexander T. Williams, Alfredo Lucas

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Abstract Itaconate is an immunomodulatory metabolite that alters mitochondrial metabolism and immune cell function. This organic acid endogenously synthesized via tricarboxylic (TCA) downstream of TLR signaling. Itaconate-based treatment strategies are being explored to mitigate numerous inflammatory conditions. However, little known about the turnover rate itaconate in circulation, kinetics its degradation, broader consequences on metabolism. By combining mass spectrometry vivo 13 C tracing, we demonstrate rapidly eliminated from plasma, excreted urine, fuels TCA cycle specifically liver kidneys. These studies further revealed converted into acetyl-CoA, mesaconate, citramalate mitochondria. administration also influenced branched-chain amino succinate levels, indicating a functional impact dehydrogenase (SDH) methylmalonyl-CoA mutase (MUT) activity. Our findings uncovered previously unknown aspect metabolism, highlighting rapid catabolism contrasts cultured cells.

Язык: Английский

Процитировано

Dissecting S-itaconation at host–pathogen interactions with chemical proteomics tools DOI

Zihua Liu, Chu Wang

Current Opinion in Microbiology, Год журнала: 2025, Номер 83, С. 102579 - 102579

Опубликована: Янв. 21, 2025

Язык: Английский

Процитировано

Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets DOI

Guangpeng Gao, Xindi Zhang

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Язык: Английский

Процитировано

Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy DOI

Peiyun Liao,

Ying Zhou,

Yingqi Qiu

и другие.

Cancer and Metastasis Reviews, Год журнала: 2025, Номер 44(2)

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation DOI

Eva M. Pålsson‐McDermott, Luke O'neill

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect the response. Metabolic intermediates accumulate a result adaptations mediate functions outside metabolism regulation immunity inflammation. In macrophages, there been major focus on 3 metabolites linked to Krebs cycle, itaconate, succinate, fumarate, which have shown regulate multiple processes. Here, we discuss recent progress these with regard their effect macrophages host defense inflammatory diseases. We also consider therapeutic opportunities presented from mimicry or by targeting enzymes that make metabolize them order leverage body's own anti-inflammatory

Язык: Английский

Процитировано

Regulation of cytokine secretion by immunometabolites DOI

Alexander Hooftman

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 191 - 208

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

Itaconate promotes an unexpected tumor immune escape mechanism DOI

Lara Haase, Christian Frezza

Cancer Cell, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024