Chitosan: A review of molecular structure, bioactivities and interactions with the human body and micro-organisms

Carbohydrate Polymers, Год журнала: 2022, Номер 282, С. 119132 - 119132

Опубликована: Янв. 14, 2022

Язык: Английский

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Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering

Carbohydrate Polymers, Год журнала: 2021, Номер 278, С. 118952 - 118952

Опубликована: Ноя. 30, 2021

Язык: Английский

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Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

ACS Applied Materials & Interfaces, Год журнала: 2021, Номер 13(29), С. 33948 - 33961

Опубликована: Июль 15, 2021

Although magnolol (Mag), an anti-inflammatory natural compound, has been demonstrated to play protective effects on ulcerative colitis (UC), its application as alternative therapeutic reagent for UC treatment is still greatly impeded due poor stability in the gastrointestinal tract and insufficient accumulation inflamed colon lesion. Nano-/microsized drug delivery systems can potentially overcome some challenges regarding oral administration of phytochemicals, which confront premature early release, degradation NPs, or sustained release MPs. In this study, we primarily loaded Mag into core-shell zein-based nanoparticles with chondroitin sulfate coating (Mag@CS-Zein NPs) average size 142.27 ± 5.11 nm, showing significant macrophage-targeting enhanced epithelial cellular uptake capacity. Then, embedded Mag@CS-Zein NPs hydrogel microspheres via electrospraying technology. The NPsinMPs presented a uniform-sized sphere 164.36 6.29 μm drug-release profiles. Compared CS-Zein developed exhibited prolonged retention inflammatory surface, seen from

Язык: Английский

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Robust hydrogel adhesives for emergency rescue and gastric perforation repair

Bioactive Materials, Год журнала: 2022, Номер 19, С. 703 - 716

Опубликована: Май 14, 2022

Development of biocompatible hydrogel adhesives with robust tissue adhesion to realize instant hemorrhage control and injury sealing, especially for emergency rescue repair, is still challenging. Herein, we report a potent adhesive by free radical polymerization N-acryloyl aspartic acid (AASP) in facile straightforward way. Through delicate adjustment steric hindrance, the synergistic effect between interface interactions cohesion energy can be achieved PAASP verified X-ray photoelectron spectroscopy (XPS) analysis simulation calculation compared poly (N-acryloyl glutamic acid) (PAGLU) amidomalonic (PAAMI) hydrogels. The strength could reach 120 kPa firmly seal broken organs withstand external force persistent stability under physiological conditions, rapid hemostasis different models on mice using as physical barrier. Furthermore, paper-based Fe3+ transfer printing method applied construct PAASP-based Janus patch both non-adhesive surfaces, which simultaneous wound healing postoperative anti-adhesion realized gastric perforation model mice. This advanced may show vast potential bio-adhesives tissue/organ repair.

Язык: Английский

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Polysaccharides, proteins, and synthetic polymers based multimodal hydrogels for various biomedical applications: A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 247, С. 125606 - 125606

Опубликована: Июль 3, 2023

Язык: Английский

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Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Gels, Год журнала: 2024, Номер 10(4), С. 216 - 216

Опубликована: Март 22, 2024

Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, structural similarity the extracellular matrix. Recent chemical advancements have bolstered versatility, facilitating integration molecules guiding cellular activities enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity network imperfections, which adversely affect mechanical properties, diffusion rates, biological activity. In response these challenges, hybrid emerged, aiming enhance strength, drug release efficiency, therapeutic effectiveness. These hydrogels, featuring improved formulations, are tailored for tissue regeneration across both soft hard tissues. The scientific community has increasingly recognized versatile characteristics particularly sector. This comprehensive review delves into recent hydrogel systems, covering diverse types, modification strategies, nano/microstructures. discussion includes innovative fabrication techniques click reactions, 3D printing, photopatterning alongside elucidation mechanisms bioactive molecules. By addressing underscores envisages a promising future various domains field.

Язык: Английский

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Strategies for efficient photothermal therapy at mild temperatures: Progresses and challenges

Chinese Chemical Letters, Год журнала: 2021, Номер 33(2), С. 575 - 586

Опубликована: Авг. 11, 2021

Язык: Английский

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3D printing hydrogels for actuators: A review

Chinese Chemical Letters, Год журнала: 2021, Номер 32(10), С. 2923 - 2932

Опубликована: Март 30, 2021

Язык: Английский

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Glycol chitosan/oxidized hyaluronic acid hydrogel film for topical ocular delivery of dexamethasone and levofloxacin

International Journal of Biological Macromolecules, Год журнала: 2020, Номер 167, С. 659 - 666

Опубликована: Дек. 2, 2020

Язык: Английский

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Bioactive Injectable Hydrogel Dressings for Bacteria-Infected Diabetic Wound Healing: A “Pull–Push” Approach

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(23), С. 26404 - 26417

Опубликована: Июнь 1, 2022

Chronic diabetic wound healing remains a challenge due to the existence of excessive danger molecules and bacteria in inflammatory microenvironment. There is an urgent need for advanced dressings that target both inflammation infection. Here, bioactive hydrogel without loading any anti-inflammatory ingredients rationally designed achieve "Pull–Push" approach efficient safe bacteria-infected by integrating molecule scavenging (Pull) with antibiotic delivery (Push) The cationic hydrogel, termed OCMC-Tob/PEI fabricated conjugation polyethylenimine (PEI) tobramycin (Tob) on oxidized carboxymethyl cellulose (OCMC) backbone via Schiff base reaction injectable, self-healing, biocompatible properties. not only displays remarkable capability capturing multiple negatively charged (e.g., cell-free DNA, lipopolysaccharides, tumor necrosis factor-α) ameliorate anti-inflammation effects but also achieves controllable long-term antibacterial activity pH-sensitive release Tob. Consequently, this multifunctional greatly expedites closure rate combined anti-infection Pseudomonas aeruginosa-infected wounds. Our work provides highly versatile treatment chronic wounds promising dressing regenerative medicine.

Язык: Английский

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