Seven-membered rings DOI
Bill C. Hawkins, Alex C. Bissember, Steven M. Wales

и другие.

Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 569 - 628

Опубликована: Янв. 1, 2023

Язык: Английский

Recent advances of Pd-π-allyl zwitterions in cycloaddition reactions DOI
Juan Du, Yunfan Li, Chang‐Hua Ding

и другие.

Chinese Chemical Letters, Год журнала: 2023, Номер 34(11), С. 108401 - 108401

Опубликована: Март 30, 2023

Язык: Английский

Процитировано

25

Recent progress in the construction of eight-membered nitrogen-heterocycles DOI
Jia Li, Ziyang Dong, Changgui Zhao

и другие.

New Journal of Chemistry, Год журнала: 2024, Номер 48(11), С. 4645 - 4669

Опубликована: Янв. 1, 2024

This review summarized the progress in synthesizing eight-membered N-heterocycles over past two decades (1995–2023), inspiring synthetic chemists to develop more efficient strategies for construction of these skeletons.

Язык: Английский

Процитировано

10

Palladium-Catalyzed Ligand-Directed Divergent Decarboxylative Cycloadditions of Vinyloxazolidine-2,4-diones with 1,3,5-Triazinanes DOI
Zhen‐Hua Wang, Xiaohui Fu, Qun Li

и другие.

Organic Letters, Год журнала: 2024, Номер 26(8), С. 1589 - 1594

Опубликована: Фев. 22, 2024

This study demonstrates a highly efficient regiodivergent ligand-controlled palladium-catalyzed cycloaddition reaction of vinyloxazolidine-2,4-diones with 1,3,5-triazinanes. In the presence diphosphine ligand, proceeds via (5+2) pathway to afford 1,3-diazepin-4-ones in excellent yields, while using monophosphine smoothly (3+2) give imidazolidin-4-ones good yields.

Язык: Английский

Процитировано

9

Catalyst-Controlled Switchable (5 + 4)/(3 + 4) Cycloadditions for the Divergent Synthesis of Pyrazole-Fused Seven- and Nine-Membered Heterocycles DOI
Jie Wang, Ting Qi,

Shurong He

и другие.

ACS Catalysis, Год журнала: 2023, Номер 13(16), С. 10694 - 10704

Опубликована: Авг. 1, 2023

Developing diversity-oriented synthetic approaches for medium-sized rings is of great interest, and the divergent synthesis with different ring sizes poses a challenging task. In this study, we present catalyst-controlled switchable (5 + 4)/(3 4) cycloaddition strategy seven- nine-membered heterocycles. Utilizing two 4-aminopyridine Lewis base catalysts, pyrazole-fused benzazepines or benzoxazonines can be efficiently assembled from same substrates. These products exhibit good stability without interconversion under reaction conditions elevated temperatures. The origin chemoselectivity was elucidated by means computational studies involving DFT calculations, distortion/interaction analysis, noncovalent interaction analysis.

Язык: Английский

Процитировано

16

Pd-catalyzed exclusively regioselective [5 + 4] cycloaddition for the construction of 1,5-di/ox-azonanes DOI
Wenqi Liu,

Meng Zang,

Jian Zhang

и другие.

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(7), С. 1680 - 1685

Опубликована: Янв. 1, 2023

An efficient approach for the exclusively regioselective construction of 1,5-di/ox-azonanes via Pd-catalyzed [5 + 4] cycloaddition has been developed.

Язык: Английский

Процитировано

14

Rapidly diastereoselective assembly of ten-membered N-heterocycles between two 1,3-dipoles and their diversity to access fused N-heterocycles DOI
Yan Luo,

Yan‐Jiao Lu,

Mingyao Pan

и другие.

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110207 - 110207

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

5

Stereoselective construction of azepine-containing bridged scaffolds via organocata-lytic bicyclization of yne-allenone esters with nitrones DOI

Mengfan Li,

Shaoqing Shi, Ting Xu

и другие.

Chinese Chemical Letters, Год журнала: 2022, Номер 34(4), С. 107751 - 107751

Опубликована: Авг. 23, 2022

Язык: Английский

Процитировано

19

Enantioselective Synthesis of Ten-Membered Lactones via Palladium-Catalyzed [5 + 5] Annulation DOI

Liu Shi,

Qiang Xiong, Shuyi Wu

и другие.

Organic Letters, Год журнала: 2023, Номер 25(12), С. 2030 - 2035

Опубликована: Март 20, 2023

Ten-membered lactones are the core units of many biologically active natural products but with a great synthetic challenge. Based on principle vinylogy, novel types cyclic vinylogous anhydrides have been designed as five-carbon carbonyl synthons, further applied in [5 + 5] annulation vinylethylene carbonates under chiral palladium catalysis. This strategy features excellent regioselectivity, mild conditions, and broad substrate scope, affording range spiro ten-membered bearing oxindole pyrrolidinone motif yield (up to 99%) moderate high enantioselectivity 89% ee).

Язык: Английский

Процитировано

9

Controlled generation of ortho-quinone methides and (4+3) cyclization with 2-indolylalcohols by dual photoredox/Brønsted acid relay catalysis DOI Creative Commons
Dong Liang, Panpan Gao, Zhihan Zhang

и другие.

Green Synthesis and Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Given the significance of oxacyclic frameworks in molecular scaffolds and drug discovery, it is intriguing to precisely construct manipulate such ring systems chemical research. In this area, intermolecular, multicomponent cyclization for synthesis diversely substituted seven-membered oxacycles under simple conditions still a challenge. Here, we report dual photoredox/Brønsted acid relay catalytic strategy situ generation ortho-quinone methides subsequent (4+3) with 2-indolylalcohols. one-pot reaction, two C-C one C-O bonds are formed, providing de novo access various biologically important indole-fused, oxygen-containing heterocycles. By virtue chiral phosphoric acid, an asymmetric version can also be achieved good excellent levels enantioselectivity (up 96:4 er).

Язык: Английский

Процитировано

3

Divergent Synthesis of Dihydrofuran and Dienol Scaffolds via Pd-Catalyzed Decarboxylative Carbene Cross-Coupling DOI
Xiaolong Ma,

Erfei Miao,

Yili Sun

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Herein, we report a novel ligand-switchable Pd-catalyzed carbene coupling reaction employing vinylethylene carbonates and sulfoxonium ylides. By proper choice of ligands, the chemoselectivity process could be efficiently regulated, allowing for availability dihydrofuran or dienol scaffolds. This method features mild conditions, broad scope, remarkable synthetic utility. Compound 6f can effectively stimulate secretion GLP-1, providing promising insight into development small-molecule agonists GLP-1 receptor.

Язык: Английский

Процитировано

0