Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 569 - 628
Опубликована: Янв. 1, 2023
Язык: Английский
Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 569 - 628
Опубликована: Янв. 1, 2023
Язык: Английский
Chinese Chemical Letters, Год журнала: 2023, Номер 34(11), С. 108401 - 108401
Опубликована: Март 30, 2023
Язык: Английский
Процитировано
25New Journal of Chemistry, Год журнала: 2024, Номер 48(11), С. 4645 - 4669
Опубликована: Янв. 1, 2024
This review summarized the progress in synthesizing eight-membered N-heterocycles over past two decades (1995–2023), inspiring synthetic chemists to develop more efficient strategies for construction of these skeletons.
Язык: Английский
Процитировано
10Organic Letters, Год журнала: 2024, Номер 26(8), С. 1589 - 1594
Опубликована: Фев. 22, 2024
This study demonstrates a highly efficient regiodivergent ligand-controlled palladium-catalyzed cycloaddition reaction of vinyloxazolidine-2,4-diones with 1,3,5-triazinanes. In the presence diphosphine ligand, proceeds via (5+2) pathway to afford 1,3-diazepin-4-ones in excellent yields, while using monophosphine smoothly (3+2) give imidazolidin-4-ones good yields.
Язык: Английский
Процитировано
9ACS Catalysis, Год журнала: 2023, Номер 13(16), С. 10694 - 10704
Опубликована: Авг. 1, 2023
Developing diversity-oriented synthetic approaches for medium-sized rings is of great interest, and the divergent synthesis with different ring sizes poses a challenging task. In this study, we present catalyst-controlled switchable (5 + 4)/(3 4) cycloaddition strategy seven- nine-membered heterocycles. Utilizing two 4-aminopyridine Lewis base catalysts, pyrazole-fused benzazepines or benzoxazonines can be efficiently assembled from same substrates. These products exhibit good stability without interconversion under reaction conditions elevated temperatures. The origin chemoselectivity was elucidated by means computational studies involving DFT calculations, distortion/interaction analysis, noncovalent interaction analysis.
Язык: Английский
Процитировано
16Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(7), С. 1680 - 1685
Опубликована: Янв. 1, 2023
An efficient approach for the exclusively regioselective construction of 1,5-di/ox-azonanes via Pd-catalyzed [5 + 4] cycloaddition has been developed.
Язык: Английский
Процитировано
14Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110207 - 110207
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
5Chinese Chemical Letters, Год журнала: 2022, Номер 34(4), С. 107751 - 107751
Опубликована: Авг. 23, 2022
Язык: Английский
Процитировано
19Organic Letters, Год журнала: 2023, Номер 25(12), С. 2030 - 2035
Опубликована: Март 20, 2023
Ten-membered lactones are the core units of many biologically active natural products but with a great synthetic challenge. Based on principle vinylogy, novel types cyclic vinylogous anhydrides have been designed as five-carbon carbonyl synthons, further applied in [5 + 5] annulation vinylethylene carbonates under chiral palladium catalysis. This strategy features excellent regioselectivity, mild conditions, and broad substrate scope, affording range spiro ten-membered bearing oxindole pyrrolidinone motif yield (up to 99%) moderate high enantioselectivity 89% ee).
Язык: Английский
Процитировано
9Green Synthesis and Catalysis, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Given the significance of oxacyclic frameworks in molecular scaffolds and drug discovery, it is intriguing to precisely construct manipulate such ring systems chemical research. In this area, intermolecular, multicomponent cyclization for synthesis diversely substituted seven-membered oxacycles under simple conditions still a challenge. Here, we report dual photoredox/Brønsted acid relay catalytic strategy situ generation ortho-quinone methides subsequent (4+3) with 2-indolylalcohols. one-pot reaction, two C-C one C-O bonds are formed, providing de novo access various biologically important indole-fused, oxygen-containing heterocycles. By virtue chiral phosphoric acid, an asymmetric version can also be achieved good excellent levels enantioselectivity (up 96:4 er).
Язык: Английский
Процитировано
3Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Herein, we report a novel ligand-switchable Pd-catalyzed carbene coupling reaction employing vinylethylene carbonates and sulfoxonium ylides. By proper choice of ligands, the chemoselectivity process could be efficiently regulated, allowing for availability dihydrofuran or dienol scaffolds. This method features mild conditions, broad scope, remarkable synthetic utility. Compound 6f can effectively stimulate secretion GLP-1, providing promising insight into development small-molecule agonists GLP-1 receptor.
Язык: Английский
Процитировано
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