Abstract
An
intermolecular
copper
catalyzed
heteroannelation
reaction
using
Csp
3
‐Csp
radical
coupling
approach
has
been
accomplished
to
synthesize
2,5‐diphenyl‐3‐(pyrimidin‐2‐yl)‐3,4‐dihydro‐2
H
‐pyrrolo[2,3‐
d
]thiazole.
C−C
between
4‐thiazolidinones
and
O‐acetyl
oximes
under
Cu
catalyst
further
cyclizes
get
the
target
molecule
thiazolidine‐fused
nucleus.
This
unified
method
offers
access
novel
fused
heterocycles
with
pyrimidines
bearing
4‐thiazolidinone
in
moderate
higher
yields.
The
optimization
study
includes
various
catalysts,
oxidants,
bases
solvents
at
different
temperatures.
Green Chemistry,
Год журнала:
2024,
Номер
26(12), С. 7331 - 7336
Опубликована: Янв. 1, 2024
A
novel
photocatalytic
acylation
strategy
was
developed
harnessing
tetrabutylammonium
decatungstate
(TBADT)
as
a
hydrogen
atom
transfer
(HAT)
photocatalyst
to
facilitate
the
direct
coupling
of
aldehydes
with
N-heterocycles
at
ambient
temperature.
Organic Letters,
Год журнала:
2024,
Номер
26(25), С. 5263 - 5268
Опубликована: Июнь 14, 2024
A
green
and
sustainable
electrochemical
oxidative
cyclization
of
enaminones
with
thioamides
under
metal-
oxidant-free
conditions
has
been
developed,
providing
an
efficient
approach
for
thiazole
synthesis.
Furthermore,
1,2,4-thiadiazoles
can
be
selectively
accessed
via
the
dimerization
in
absence
enaminones.
Green Chemistry,
Год журнала:
2024,
Номер
26(8), С. 4600 - 4608
Опубликована: Янв. 1, 2024
A
metal-free
and
catalyst-free
strategy
is
reported
to
achieve
N–H
insertions
by
coupling
N
-tosylhydrazones
with
diverse
amines
including
aminopyridines,
anilines,
aliphatic
amines,
other
nucleophiles
such
as
imidazoles
indoles.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
11(1), С. 135 - 141
Опубликована: Ноя. 21, 2023
A
visible-light-induced
one-pot
three-component
reaction
of
cycloketone
oxime
esters,
NH-sulfoximines,
and
alkenes
was
developed
for
the
difunctionalization
alkenes.
A
copper-catalyzed
[4
+
2]
annulation
protocol
from
readily
available
α,β-unsaturated
ketoximes
and
dialkyl
acetylenedicarboxylates
has
been
achieved.
The
approach
enables
the
expedient
construction
of
a
series
structurally
new
highly
substituted
pyridines
with
good
functional
group
tolerance.
The
catalytic
asymmetric
multicomponent
acylation/rearrangement/cyclization
of
alkenylfurans
with
acyl
oxime
esters/arylamines
or
esters/arylamines/hydroxylamine
has
been
developed.
This
method
employs
synergistic
photoredox/Brønsted
acid
catalysis,
enabling
the
efficient
and
versatile
synthesis
multifunctionalized
[3.2.1]
[4.2.1]
bicyclic
bridged
compounds
in
high
yields
excellent
diastereo-
enantioselectivities.
Organic & Biomolecular Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
synergistic
I2/secondary
amine
catalysis
has
been
developed
for
the
modular
assembly
of
2,2'-bipyridines,
employing
oxime
esters
and
enals
as
readily
available
starting
materials.
This
method
demonstrates
a
good
substrate
scope
functional
group
tolerance
can
easily
afford
series
structurally
new
2,2'-bipyridines
in
moderate
to
yields.
An
iron-catalyzed
[3
+
2]
annulation
of
O-acyl
oximes
with
2-hydroxy-1-naphthoates
has
been
developed.
This
strategy
features
the
simultaneous
activation
both
substrates
to
form
two
radical
intermediates.
Subsequent
selective
C-N
coupling
followed
by
sequential
condensation
and
1,3-ester
migration
affords
1H-
or
3H-benzo[g]indoles.
In
terms
derived
from
4-oxocyclohexanone
4-azacyclohexanone,
further
ring-opening
furnishes
2-(2-hydroxyethyl)-
2-(2-aminoethyl)-1H-benzo[g]indoles.
