Designing a reusable chiral SPE electrode with Mg nanoparticles on graphene oxide for efficient enantioselective Grignard carboxylation of (1-bromoethyl)benzenes in a deep eutectic solvent
Catalysis Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Researchers
have
developed
a
novel
electrode
for
the
enantioselective
electro-organic
Grignard
carboxylation
of
(1-bromoethyl)benzenes
1(a–l)
with
carbon
dioxide
(CO
2
)
3(a).
Язык: Английский
Photoredox Site-Selective C(sp3)–H Alkylation of 1-(o-Iodoaryl)-alkan-1-ones with Activated Alkenes Enabled by Hydrogen Atom Transfer
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
A
visible-light-mediated
photoredox
catalysis
for
β-C(sp3)–H
alkylation
of
1-(o-iodoaryl)alkan-1-ones
with
alkenes
via
1,5-hydrogen
atom
transfer
and
alkene
alkylarylation
to
produce
diverse
β-alkyl
arylalkanones
containing
a
quaternary
carbon
center
is
presented.
This
method
applicable
wide
range
activated
alkenes.
Mechanistic
studies
suggest
that
the
reaction
involves
radical
process.
Язык: Английский
Photoinduced Site-Selective Aryl C-H Borylation with Electron-Donor-Acceptor Complex Derived from B2Pin2 and Isoquinoline
Molecules,
Год журнала:
2024,
Номер
29(8), С. 1783 - 1783
Опубликована: Апрель 14, 2024
Due
to
boron’s
metalloid
properties,
aromatic
boron
reagents
are
prevalent
synthetic
intermediates.
The
direct
borylation
of
aryl
C-H
bonds
for
producing
compounds
offers
an
appealing,
one-step
solution.
Despite
significant
advances
in
this
field,
achieving
regioselective
bond
using
simple
and
readily
available
starting
materials
still
remains
a
challenge.
In
work,
we
attempted
enhance
the
reactivity
electron-donor-acceptor
(EDA)
complex
by
selecting
different
bases
replace
organic
base
(NEt3)
used
our
previous
research.
To
delight,
when
NH4HCO3
as
base,
have
achieved
mild
visible-light-mediated
reaction
with
exceptional
regioselectivity
(rr
>
40:1
single
isomers).
Compared
methodologies,
protocol
provides
more
efficient
broader
scope
through
use
N-Bromosuccinimide.
protocol’s
good
functional-group
tolerance
excellent
enable
functionalization
variety
biologically
relevant
novel
cascade
transformations.
Mechanistic
experiments
theoretical
calculations
conducted
study
indicated
that,
certain
arenes,
might
proceed
new
mechanism,
which
involves
formation
transient
EDA
complex.
Язык: Английский
Scalable and Integrated Four-step Continuous-Flow Synthesis of Ibuprofen Using a Zinc-Catalyzed 1,2-Aryl Migration Strategy
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
12(22), С. 8512 - 8520
Опубликована: Май 20, 2024
Ibuprofen
is
an
essential
nonsteroidal
anti-inflammatory
drug
(NSAID)
which
still
inaccessible
to
more
than
100
million
patients
worldwide.
Although
three
elegant
continuous-flow
approaches
toward
this
NSAID
have
been
developed,
the
major
defect
of
requiring
use
a
stoichiometric
amount
highly
toxic,
corrosive,
and
expensive
oxidizing
reagents
(such
as
di(acetoxy)phenyl
iodide
(PhI(OAc)2)
iodine
monochloride
(ICl))
prevents
their
application
in
industrial
manufacturing.
Herein,
novel
catalytic
synthesis
ibuprofen
from
commercially
available
isobutylbenzene
performed
by
linear
sequence
involving
four
chemical
transformations
without
conducting
solvent
exchanges
or
intermediate
purifications.
This
newly
developed
proof-of-principle
regime
provided
access
global
yield
80.6%
with
average
94.7%
for
each
step
total
reaction
time
32.5
min,
corresponding
throughput
15.22
g/h.
Язык: Английский
Iron Nanoparticle-Catalyzed Enantioselective Electro-Organic Carboxylation of Styrenes with CO2 Using Graphene Oxide Modified with PyrCO-cyclo@Fe in the Presence of Deep Eutectic Electrolyte and Solvent
Catalysis Surveys from Asia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Язык: Английский
New route to preparation of loxoprofen through Mizoroki-Heck reaction as the key step
Synthetic Communications,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Дек. 18, 2024
The
current
study
describes
a
new
preparation
of
loxoprofen.
whole
process
includes
five
steps
from
cheap
cyclopentanone
and
methyl
4-bromophenylacetate
as
the
starting
materials.
key
intermediate
is
obtained
through
Mizoroki-Heck
reaction
2-methylenecyclopentanone
2-(4-bromophenyl)propanoate.
desired
loxoprofen
yielded
hydrogenation
followed
by
hydrolysis
in
56%
overall
yield
with
99.7%
purity.
Язык: Английский