Hydrophobic Modification of Hydrogels Enhances Antibacterial Activity and Promotes Wound Healing

Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(3)

Опубликована: Март 1, 2025

ABSTRACT The development of hydrogel wound dressings that facilitate rapid healing is a complex task, primarily due to the necessity integrating multiple functional attributes, including air permeability, adhesion, antibacterial efficacy, and biocompatibility. In this study, we employed fatty acid‐modified carboxymethyl chitosan (CMCS) fabricate multifunctional dressing. This dressing exhibits adjustable hydrophobicity, robust mechanical properties, potent activity, with polyacrylamide (PAM) tannic acid (TA) serving as primary constituents. study demonstrated incorporation hydrophobic structures significantly enhanced tensile strength, compressive adhesive capacity hydrogels. addition, release curve TA showed acids played vital role in enhancing properties hydrogels, which may increase TA. Furthermore, length carbon chain has significant effect on hydrogel. summary, TA/(C14‐g‐CMCS)/PAM excellent can effectively prevent bleeding, accelerate closure, promote tissue regeneration. Therefore, TA/(FA‐g‐CMCS)/PAM hydrophobicity expected be best candidate for accelerating promoting regeneration skin tissue.

Язык: Английский

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Heparin and Gelatin Co-Functionalized Polyurethane Artificial Blood Vessel for Improving Anticoagulation and Biocompatibility

Bioengineering, Год журнала: 2025, Номер 12(3), С. 304 - 304

Опубликована: Март 18, 2025

The primary challenges in the tissue engineering of small-diameter artificial blood vessels include inadequate mechanical properties and insufficient anticoagulation capabilities. To address these challenges, urea-pyrimidone (Upy)-based polyurethane elastomers (PIIU-B) were synthesized by incorporating quadruple hydrogen bonding within polymer backbone. synthesis process employed poly(L-lactide-ε-caprolactone) (PLCL) as soft segment, while di-(isophorone diisocyanate)-Ureido pyrimidinone (IUI) isophorone diisocyanate (IPDI) utilized hard segment. resulting PIIU-B vessel with a diameter 4 mm was fabricated using electrospinning technique, achieving an optimized IUI/IPDI composition ratio 1:1. Enhanced multiple bonds, exhibited robust elastic modulus 12.45 MPa, extracellular matrix (ECM)-mimetic nanofiber morphology, high porosity 41.31%. Subsequently, underwent dual-functionalization low-molecular-weight heparin gelatin via ultraviolet (UV) crosslinking (designated PIIU-B@LHep/Gel), which conferred superior biocompatibility exceptional properties. study revealed improved anti-platelet adhesion characteristics well prolonged activated partial thromboplastin time (APTT) 157.2 s thrombin (TT) 64.2 vitro. Following seven-day subcutaneous implantation, PIIU-B@LHep/Gel excellent biocompatibility, evidenced complete integration surrounding peri-implant tissue, significant cell infiltration, collagen formation vivo. Consequently, polyurethane-based vessels, reinforced bonds dual-functionalized gelatin, present promising candidates for vascular engineering.

Язык: Английский

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Microwave-Fluidic Continuous Manufacturing of Ultrasmall Silver Nanoparticles in a Polycaprolactone Matrix as Antibacterial Coatings

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Fast, energy-efficient, and continuous manufacturing of nanoparticles (NPs) with controlled size distribution in polymer matrices is challenging. Herein, a microwave-powered dual-injection flow reactor presented to prepare silver NP (AgNP)/polycaprolactone (PCL) nanocomposites (AgNP/PCL NCs). Ultrasmall spherical AgNPs (US-AgNPs, 1.86 ± 0.77 nm) can be manufactured the PCL matrix less than 3 min at ∼35 °C by applying 60 W microwave power combined rate 1.25:1.25 mL/min (Pump1:Pump2). The effect amount on thermal, optical, antimicrobial properties crystallinity NCs are discussed. NC independent NP's amount, while film roughness highly dependent size. antibacterial activity US-AgNPs-containing toward Escherichia coli (∼98.2%), Pseudomonas aeruginosa Staphylococcus aureus (∼99.1%) higher big AgNP-containing (82.3%, 85.7%, 92.3%, respectively), signifying strong dependency instead Ag concentration.

Язык: Английский

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Nanomaterials for Cryomedicine: Classification, Mechanisms, and Applications

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Abstract Cold temperatures exhibit a broader safety margin than hyperthermia, thereby enhancing their controllability and compatibility within biological systems. Nanomaterials with diverse structures rich functionalities can respond to cold temperatures, converting physical signals from environments into actionable effects. The advancement of nanomaterials nanotechnology has expanded the impact on systems, fostering emergence cryomedicine as multidisciplinary field. In this review, temperature‐responsive are categorized thermally conductive nanomaterials, phase‐change temperature‐sensitive polymer pyroelectric thermoelectric nanomaterials. methods devices for applying summarized, emphasis intelligent temperature equipment. Furthermore, biomedical applications summarized discussed, including cryoablation, drug delivery, cell cryopreservation, catalytic therapy, antimicrobial biosensing, electronic skin. Finally, perspectives challenges potential solutions in biomedicine provided, aiming offer insights cryomedicine.

Язык: Английский

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Polyelectrolyte composite-based multifunctional anti-fog coating with antibacterial, self-cleaning, and self-healing properties

Progress in Organic Coatings, Год журнала: 2025, Номер 207, С. 109404 - 109404

Опубликована: Май 29, 2025

Язык: Английский

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A review of advances & potential of applying nanomaterials for biofilm inhibition

npj Clean Water, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 20, 2024

Biofilms pose significant challenges due to their role in biological contamination and water quality damage. This review explores physical/chemical strategies for controlling biofilms, emphasizing the potential of nanomaterials enhance antibiofilm performance. Popular characterization methods biofilm studies are summarized two aspects, bactericidal monitoring, anti-adhesion which serve as a toolbox future studies. The insights provided crucial advancing management various fields.

Язык: Английский

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From Synthesis to Functionality: Tailored Ionic Liquid-Based Electrospun Fibers with Superior Antimicrobial Properties

Polymers, Год журнала: 2024, Номер 16(15), С. 2094 - 2094

Опубликована: Июль 23, 2024

Herein, we report an efficient and facile strategy for the preparation of imidazolium-based ionic liquid (IL) monomers ([CnVIm][Br], n = 2, 4, 6, 8, 10, 12) their corresponding polymeric liquids (PILs) with potent antimicrobial activities against Gram-negative Gram-positive bacteria fungi. The electrospinning technique was utilized to tailor polymers highest potency into porous membranes that can be easily implemented diverse systems extend practical bactericidal application. mechanism obtained ILs, polymers, nanomaterials is considered concerning bearing chain length, polymerization process, applied processing provides a unique fibrous structure. structure composition selected due well-established inherent amphiphilicity 1-alkylimidazolium ILs possess, coupled proven antimicrobial, antiseptic, antifungal behavior. customizable nature PILs complemented exploited development innovative performances born from intrinsic polymer itself, offering solutions increasing challenge bacterial resistance. This study opens up new prospects toward designer providing complete route in designing revolutionizing approach fabricating multi-functional tunable physicochemical, surface properties, interesting morphology.

Язык: Английский

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Effects of Secondary Amine and Molecular Weight on the Biological Activities of Cationic Amphipathic Antimicrobial Macromolecules

Biomacromolecules, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Cationic amphipathic antimicrobial agents inspired by peptides (AMPs) have shown potential in combating multidrug-resistant bacteria because of minimal resistance development. Here, this study focuses on the development novel cationic macromolecules form dendrons and polymers with different molecular weights that employ secondary amine piperidine derivative as moiety. Generally, compounds, especially at low weights, stronger bacteriostatic, bactericidal, inner membrane disruption abilities than those their primary counterparts. Low weight

Язык: Английский

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Development of Bifunctional Electrospun Filters Incorporating Surfactants for Enhanced Particulate Matter Filtration and Antimicrobial Activity

Fibers and Polymers, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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