g-C3N4-Based Heterogeneous Photocatalyzed Synthesis and Evaluation of Antitumor Activities of Fluoroalkylated 4H-Pyrido[1,2-a]pyrimidin-4-ones
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
The
first
example
of
heterogeneous
photoredox-catalyzed
fluoroalkylation
4H-pyrido[1,2-a]pyrimidin-4-ones
has
been
developed.
With
low-cost
commercial
g-C3N4
as
the
recyclable
photocatalyst
and
cheap
sodium
fluoroalkyl
sulfonates
source,
a
variety
fluoroalkylated
pyridopyrimidinones
were
constructed
in
moderate
to
high
yields.
present
reaction
can
be
easily
scaled
up
with
good
efficiency,
catalytic
system
reused
5
times
slight
loss
activities.
Furthermore,
biological
activity
synthesized
compounds
was
preliminarily
investigated.
Язык: Английский
Photocatalytic Ring-Closing Metathesis/Amination of 1,6-Enynes and 1,7-Enynes: Synthesis of α,β-Unsaturated γ-Lactams and Quinolin-2-ones
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
A
photocatalyzed
ring-closing
metathesis/amination
of
1,6-enynes
and
1,7-enynes
using
alkyl
oxime
esters
as
both
an
alkene
deconstruction
auxiliary
amination
source
is
present
for
the
synthesis
α,β-unsaturated
γ-lactams
quinolin-2-ones.
Preliminary
mechanistic
studies
suggest
that
intramolecular
1,5-hydrogen
atom
transfer
key
to
generation
unstabilized
radicals,
which
subsequently
promote
homolytic
Cα-Cβ
cleavage
under
driving
force
formation
more
stable
captodative
radicals.
Язык: Английский