Rh-Catalyzed and Self-Directed Aromatic C–H Activation of Enaminones to Divergent Alkenylated and Annulated Compounds
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
Язык: Английский
Eco-Friendly and Efficient Synthesis of 2-Hydroxy-3-Hydrazono-Chromones Through α,β-C(sp2)–H Bond Difunctionalization/Chromone Annulation Reaction of o-Hydroxyaryl Enaminones, Water, and Aryldiazonium Salts
Molecules,
Год журнала:
2025,
Номер
30(6), С. 1194 - 1194
Опубликована: Март 7, 2025
A
novel,
eco-friendly,
and
efficient
method
for
constructing
2,3-disubstituted
chromone
skeletons
from
readily
available
water,
o-hydroxyaryl
enaminones
(o-HPEs),
aryldiazonium
salts
has
been
developed
under
mild
reaction
conditions.
This
α,β-C(sp2)–H
bond
difunctionalization/chromone
annulation
strategy
is
achieved
by
building
two
C(sp3)–O
bonds
a
C(sp2)-N
bond,
which
provides
practical
pathway
the
preparation
of
2-hydroxy-3-hydrazono-chromones
in
moderate
to
excellent
yields,
enabling
broad
substrate
scope
good
functional
group
tolerance,
as
well
gram-scale
synthesis.
protocol
offers
valuable
tool
synthesizing
diverse
functionalized
chromones
with
potential
applications
drug
discovery
industrial
Язык: Английский
Electrochemical Annulation of p-Alkoxy or p-Hydroxy Anilines with Enaminones for Selective Indole and Benzofuran Synthesis
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
The
green
and
sustainable
electrochemical
oxidative
cyclization
of
enaminones
with
p-methoxy/p-hydroxy
anilines
has
been
developed,
enabling
the
regioselective
synthesis
indoles
benzofurans.
methods
are
significant
advantage
not
only
due
to
mild
metal-free
conditions,
but
also
because
employment
easily
available
stable
aniline
substrates
replace
unstable
quinoneimide
for
a
similar
annulation
in
previous
work.
Язык: Английский