Abstract
The
development
of
efficient
drug
delivery
systems
is
essential
for
improving
the
efficacy
and
safety
cancer
drugs,
particularly
aggressive
difficult‐to‐treat
cancers.
Covalent
organic
frameworks
(COFs)
are
emerging
as
innovative
porous
nanomaterials
in
(DDS),
due
to
their
unique
properties,
including
metal‐free
skeleton,
predetermined
structures
pore
geometries,
high
porosity,
large
surface
area,
facile
modification
potential,
good
biocompatibility.
These
characteristics
make
COFs
excellent
candidates
by
enhancing
loading
capacity
enabling
precise
encapsulation.
This
review
emphasizes
importance
donor‐acceptor‐based
COFs,
which
provide
channels
charge
transportation,
we
also
explore
how
π‐conjugated
skeleton
enhances
its
long‐acting
fluorescent
properties
facilitates
uptake
via
cell
endocytosis.
While
this
primarily
focuses
on
recent
advancements
COF‐based
targeted
DDS,
it
acknowledges
challenges
posed
diverse
geometries
materials
discusses
potential
solutions.
Further,
underlines
developing
future
carriers
that
can
successfully
specifically
target
cells,
treatment
efficiency
while
reducing
adverse
side
effects.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(44)
Опубликована: Сен. 15, 2023
The
high
local
electron
density
and
efficient
charge
carrier
separation
are
two
important
factors
to
affect
photocatalytic
activity,
especially
for
the
CO2
photoreduction
reaction.
However,
systematic
studies
on
structure-functional
relationship
regarding
above
based
precisely
structure
model
rarely
reported.
Herein,
as
a
proof-of-concept,
we
developed
new
strategy
evaluation
of
by
controlling
relative
electron-deficient
(ED)
electron-rich
(ER)
intensity
monomer
at
molecular
level
three
rational-designed
vinylene-linked
sp2
carbon-covalent
organic
frameworks
(COFs).
As
expected,
as-prepared
carbon-conjugated
metal-covalent
framework
(MCOFs)
(VL-MCOF-1)
with
junction
exhibited
excellent
activities
-to-HCOOH
conversion
(283.41
μmol
g-1
h-1
)
selectivity
97.1
%,
much
higher
than
VL-MCOF-2
g-C34
N6
-COF,
which
is
due
synergistic
effect
multi-electronic
metal
clusters
(Cu3
(PyCA)3
(PyCA=pyrazolate-4-carboxaldehyde)
strong
ER
roles
cyanopyridine
units
ED
active
sites,
well
boosted
photo-induced
efficiency
vinyl
connection
increased
light
utilization
ability.
These
results
not
only
provide
regulating
electron-density
distribution
photocatalysts
but
also
offers
profound
insights
clusters-based
COFs
effective
conversion.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(23), С. 16229 - 16236
Опубликована: Май 30, 2024
Employing
covalent
organic
frameworks
(COFs)
for
the
photocatalytic
CO2
reduction
reaction
(CDRR)
to
generate
high-value
chemical
fuels
and
mitigate
greenhouse
gas
emissions
represents
a
sustainable
catalytic
conversion
approach.
However,
achieving
superior
CDRR
performance
is
hindered
by
challenges
of
low
charge
separation
efficiency,
poor
stability,
high
preparation
costs
associated
with
COFs.
Herein,
in
this
work,
we
utilized
perfluorinated
metallophthalocyanine
(MPcF16)
biomolecule
compound
ellagic
acid
(EA)
as
building
blocks
actualize
functional
named
EPM-COF
(M
=
Co,
Ni,
Cu).
The
designed
EPCo-COF,
featuring
cobalt
metal
active
sites,
demonstrated
an
impressive
CO
production
rate
selectivity
(CDRR).
Moreover,
following
alkaline
treatment
(EPCo-COF-AT),
COF
exposed
carboxylic
anion
(COO–)
hydroxyl
group
(OH),
thereby
enhancing
electron-donating
capability
EA.
This
modification
achieved
heightened
17.7
mmol
g–1
h–1
outstanding
97.8%
efficient
CDRR.
Theoretical
calculations
further
illustrated
that
EPCo-COF-AT
functionalized
COO–
OH
can
effectively
alleviate
energy
barriers
involved
process,
which
facilitates
proton-coupled
electron
transfer
processes
enhances
on
sites
within
EPCo-COF-AT.
Abstract
The
development
of
efficient
drug
delivery
systems
is
essential
for
improving
the
efficacy
and
safety
cancer
drugs,
particularly
aggressive
difficult‐to‐treat
cancers.
Covalent
organic
frameworks
(COFs)
are
emerging
as
innovative
porous
nanomaterials
in
(DDS),
due
to
their
unique
properties,
including
metal‐free
skeleton,
predetermined
structures
pore
geometries,
high
porosity,
large
surface
area,
facile
modification
potential,
good
biocompatibility.
These
characteristics
make
COFs
excellent
candidates
by
enhancing
loading
capacity
enabling
precise
encapsulation.
This
review
emphasizes
importance
donor‐acceptor‐based
COFs,
which
provide
channels
charge
transportation,
we
also
explore
how
π‐conjugated
skeleton
enhances
its
long‐acting
fluorescent
properties
facilitates
uptake
via
cell
endocytosis.
While
this
primarily
focuses
on
recent
advancements
COF‐based
targeted
DDS,
it
acknowledges
challenges
posed
diverse
geometries
materials
discusses
potential
solutions.
Further,
underlines
developing
future
carriers
that
can
successfully
specifically
target
cells,
treatment
efficiency
while
reducing
adverse
side
effects.
