Abstract
Hydrogen
peroxide
(H
2
O
)
is
a
primary
reactive
oxygen
species
(ROS)
that
can
act
as
chemical
signal
in
developing
and
progressing
serious
life‐threatening
diseases
like
cancer.
Due
to
the
stressful
nature
of
H
,
there
an
urgent
need
develop
sensitive
analytical
approaches
be
applied
various
biological
matrices.
Herein,
portable
point‐of‐care
electrochemical
system
based
on
MXene‐Co
3
4
nanocomposites
detect
different
cancer
cell‐lines
presented.
The
developed
sensor
affordable,
disposable,
highly
selective
for
detection.
This
approach
achieves
dynamic
linear
range
75
µm
with
LOD
0.5
µ
m
LOQ
1.6
.
To
improve
practical
application,
level
ROS
evaluated
both
cell
lines
MDA‐MB‐231
DU145,
respectively,
breast
prostate
cancers,
healthy
HaCat
cells.
Moreover,
same
cells
are
treated
transforming
growth
factor‐β1,
modified
strip
capable
monitorROS
variation.
results
satisfactory
compared
cellular
fluorescent
assay
DCFH/DCFH‐DA.
These
open
new
perspectives
real‐time
monitoring
progression
efficacy
therapy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(23)
Опубликована: Фев. 14, 2024
Abstract
Bioelectrode
is
critical
to
many
biomedical
researches.
However,
traditional
materials
(typically
noble
metals)
and
manufacturing
techniques
limit
the
large‐scale
production
of
bioelectrodes.
Herein,
a
fast
electrochemical
approach
proposed
deposit
versatile
MXene/polydopamine
(PDA)
composites
on
metalized
substrate.
PDA
coating
can
improve
adhesion
between
MXene
substrate,
while
provides
rough
surfaces
with
unique
micro/nanostructure
outstanding
electrical/optical/thermal
performance.
The
impedance
as‐prepared
bioelectrode
at
1
kHz
down
8.48
Ω
cm
2
.
corresponding
cathodic
charge
storage
capacity
(CSC
c
)
injection
(CIC)
are
up
≈250
6.59
mC
−2
respectively,
much
superior
that
bare
Pt
other
conventional
material‐based
electrodes.
MXene/PDA
also
demonstrate
robust
stability
under
continuous
electrostimulation
for
×
10
8
pulse
cycles
1000
CV
cycles.
Moreover,
show
high
rapid
photothermal
response.
Photoelectrochemical
activity
observed
photocurrent,
≈40
folds
larger
than
Pt.
utility
this
new
electrode
in
ascorbic
acid
sensing
demonstrated.
Excellent
biocompatibility
verified
via
neuron
test
viability
assay.
Catalysts,
Год журнала:
2022,
Номер
12(12), С. 1576 - 1576
Опубликована: Дек. 4, 2022
Green
hydrogen
production
via
electrocatalytic
water
splitting
paves
the
way
for
renewable,
clean,
and
sustainable
(H2)
generation.
H2
gas
is
produced
from
cathodic
evolution
reaction
(HER),
where
catalyzed
primarily
Pt-based
catalysts
under
both
acidic
alkaline
environments.
Lowering
loading
of
Pt
search
alternative
active
HER
still
an
ongoing
challenge.
Two-dimensional
MXenes
are
effective
supports
to
stabilize
homogenously
distribute
HER-active
electrocatalysts
boost
performance.
Factors
involved
in
effectiveness
their
role
include
transition
metal
types
termination
groups.
Recently,
tailoring
conditions
during
synthesis
has
made
it
possible
tune
morphology
multilayers
few
layers
(delaminated),
formation
porous
MXenes,
those
with
unique
crumpled
rolled
structures.
Changing
alters
surface
area,
exposed
sites
accessibility
electrolyte
materials/ions
these
sites.
This
review
provides
insight
into
effects
varying
towards
activity
MXene
itself
composites/hybrids
catalysts.
Synthesis
methods
obtain
different
morphologies
also
summarized.
