Abstract
Specific
biomarker‐activatable
probes
have
revolutionized
theranostics,
being
beneficial
for
precision
medicine.
Hypoxia
is
a
critical
pathological
characteristic
prevalent
in
numerous
major
diseases
such
as
cancers,
cardiovascular
disorders,
inflammatory
diseases,
and
acute
ischemia.
Aggregation‐induced
emission
luminogens
(AIEgens)
emerged
promising
tool
to
tackle
the
biomedical
issues.
Of
particular
significance
are
hypoxia‐responsive
AIEgens,
representing
kind
of
crucial
probe
capable
delicately
sensing
responding
hypoxic
microenvironment,
thereby
enhancing
disease
diagnosis
treatment.
In
this
review,
we
summarize
recent
advances
AIEgens
varied
applications.
The
structures
based
on
azobenzene,
nitrobenzene,
N‐oxide
presented,
which
response
reduction
property
bring
about
significant
alternations
spectra
and/or
fluorescence
intensity.
bioapplications
including
imaging
therapy
tumor
ischemia
discussed.
Moreover,
review
sheds
light
future
challenges
prospects
field.
This
aims
provide
comprehensive
guidance
understanding
into
development
activatable
bioprobes,
especially
improving
outcome
related
diseases.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(8), С. 3976 - 4019
Опубликована: Янв. 1, 2024
This
review
focuses
on
the
design
strategy,
spectroscopic
characteristics,
and
functionalization
of
mitochondrion-targeted
BODIPY
dyes,
providing
an
overview
these
dyes
for
bioimaging
photodynamic
therapy.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(32)
Опубликована: Май 23, 2024
Clear
delineation
of
tumor
margins
is
essential
for
accurate
resection
and
decreased
recurrence
rate
in
the
clinic.
Fluorescence
imaging
emerging
as
a
promising
alternative
to
traditional
visual
inspection
by
surgeons
intraoperative
imaging.
However,
probes
lack
accuracy
diagnosis,
making
it
difficult
depict
boundaries
accurately.
Herein,
we
proposed
an
offensive
defensive
integration
(ODI)
strategy
based
on
"attack
systems
(invasive
peptidase)
defense
(reductive
microenvironment)"
multi-dimensional
characteristics
design
activatable
fluorescent
precisely.
Screened
out
from
series
ODI
strategy-based
probes,
ANQ
performed
better
than
unilateral
correlation
distinguishing
between
cells
normal
minimizing
false-positive
signals
living
metabolic
organs.
To
further
improve
signal-to-background
ratio
vivo,
derivatized
FANQ,
was
prepared
successfully
applied
distinguish
orthotopic
hepatocellular
carcinoma
tissues
adjacent
mice
models
clinical
samples.
This
work
highlights
innovative
develop
rapid
diagnosis
tumors
high-precision
boundaries,
providing
more
efficient
tools
future
applications
assisted
resection.
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1168 - 1168
Опубликована: Март 6, 2024
Many
important
biological
species
have
been
identified
as
cancer
biomarkers
and
are
gradually
becoming
reliable
targets
for
early
diagnosis
late
therapeutic
evaluation
of
cancer.
However,
accurate
quantitative
detection
remains
challenging
due
to
the
complexity
systems
diversity
development.
Fluorescent
probes
extensively
utilized
identifying
substances
their
notable
benefits
being
non-invasive,
quickly
responsive,
highly
sensitive
selective,
allowing
real-time
visualization,
easily
modifiable.
This
review
critiques
fluorescent
used
detecting
imaging
over
last
five
years.
Focuses
made
on
design
strategies
small-molecule
nano-sized
probes,
construction
methods
fluorescence
sensing
platforms,
further
applications
in
multiple
biomarkers,
including
enzymes,
reactive
oxygen
species,
sulfur
microenvironments.
aims
guide
development
excellent
diagnostic
promote
broad
application
analysis
diagnosis.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 7, 2025
3-Amino
boron
dipyrromethenes
(BODIPYs)
are
a
versatile
class
of
fluorophores
widely
utilized
in
live
cell
imaging,
photodynamic
therapy,
and
fluorescent
materials
science.
Despite
the
growing
demand
for
optically
active
BODIPYs,
synthesis
chiral
3-amino-BODIPYs,
particularly
catalytic
asymmetric
version,
remains
challenge.
Herein,
we
report
boron-stereogenic
3-amino-BODIPYs
via
palladium-catalyzed
desymmetric
C–N
cross-coupling
prochiral
3,5-dihalogen-BODIPYs.
This
approach
features
broad
substrate
scope,
excellent
functional
group
tolerance,
high
efficiency,
remarkable
enantioselectivities,
under
mild
reaction
conditions.
Further
stereospecific
formation
3,5-diamino-BODIPYs,
along
with
an
investigation
into
photophysical
properties
resulting
optical
BODIPYs
also
explored.
protocol
not
only
enriches
chemical
space
chiroptical
BODIPY
dyes
but
contributes
to
realm
chemistry.
(BODIPYs),
which
useful
science,
authors
first
cross-couplings.
Chemical Communications,
Год журнала:
2024,
Номер
60(45), С. 5770 - 5789
Опубликована: Янв. 1, 2024
This
highlight
reviews
various
strategies
for
constructing
BODIPY-based
photocages,
their
photodecaging
mechanisms,
and
applications
in
the
biomedical
field.
