Near infrared fluorescent probes for detecting and imaging active small molecules

Coordination Chemistry Reviews, Год журнала: 2023, Номер 482, С. 215080 - 215080

Опубликована: Фев. 21, 2023

Язык: Английский

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Mitochondria-targeted BODIPY dyes for small molecule recognition, bio-imaging and photodynamic therapy

Chemical Society Reviews, Год журнала: 2024, Номер 53(8), С. 3976 - 4019

Опубликована: Янв. 1, 2024

This review focuses on the design strategy, spectroscopic characteristics, and functionalization of mitochondrion-targeted BODIPY dyes, providing an overview these dyes for bioimaging photodynamic therapy.

Язык: Английский

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Dual‐Locked Fluorescent Probes Activated by Aminopeptidase N and the Tumor Redox Environment for High‐Precision Imaging of Tumor Boundaries

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(32)

Опубликована: Май 23, 2024

Clear delineation of tumor margins is essential for accurate resection and decreased recurrence rate in the clinic. Fluorescence imaging emerging as a promising alternative to traditional visual inspection by surgeons intraoperative imaging. However, probes lack accuracy diagnosis, making it difficult depict boundaries accurately. Herein, we proposed an offensive defensive integration (ODI) strategy based on "attack systems (invasive peptidase) defense (reductive microenvironment)" multi-dimensional characteristics design activatable fluorescent precisely. Screened out from series ODI strategy-based probes, ANQ performed better than unilateral correlation distinguishing between cells normal minimizing false-positive signals living metabolic organs. To further improve signal-to-background ratio vivo, derivatized FANQ, was prepared successfully applied distinguish orthotopic hepatocellular carcinoma tissues adjacent mice models clinical samples. This work highlights innovative develop rapid diagnosis tumors high-precision boundaries, providing more efficient tools future applications assisted resection.

Язык: Английский

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Recent Advances in Fluorescent Probes for Cancer Biomarker Detection

Molecules, Год журнала: 2024, Номер 29(5), С. 1168 - 1168

Опубликована: Март 6, 2024

Many important biological species have been identified as cancer biomarkers and are gradually becoming reliable targets for early diagnosis late therapeutic evaluation of cancer. However, accurate quantitative detection remains challenging due to the complexity systems diversity development. Fluorescent probes extensively utilized identifying substances their notable benefits being non-invasive, quickly responsive, highly sensitive selective, allowing real-time visualization, easily modifiable. This review critiques fluorescent used detecting imaging over last five years. Focuses made on design strategies small-molecule nano-sized probes, construction methods fluorescence sensing platforms, further applications in multiple biomarkers, including enzymes, reactive oxygen species, sulfur microenvironments. aims guide development excellent diagnostic promote broad application analysis diagnosis.

Язык: Английский

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Catalytic asymmetric C–N cross-coupling towards boron-stereogenic 3-amino-BODIPYs

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 7, 2025

3-Amino boron dipyrromethenes (BODIPYs) are a versatile class of fluorophores widely utilized in live cell imaging, photodynamic therapy, and fluorescent materials science. Despite the growing demand for optically active BODIPYs, synthesis chiral 3-amino-BODIPYs, particularly catalytic asymmetric version, remains challenge. Herein, we report boron-stereogenic 3-amino-BODIPYs via palladium-catalyzed desymmetric C–N cross-coupling prochiral 3,5-dihalogen-BODIPYs. This approach features broad substrate scope, excellent functional group tolerance, high efficiency, remarkable enantioselectivities, under mild reaction conditions. Further stereospecific formation 3,5-diamino-BODIPYs, along with an investigation into photophysical properties resulting optical BODIPYs also explored. protocol not only enriches chemical space chiroptical BODIPY dyes but contributes to realm chemistry. (BODIPYs), which useful science, authors first cross-couplings.

Язык: Английский

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Evolution of Aza-BODIPY dyes-A hot topic

Coordination Chemistry Reviews, Год журнала: 2023, Номер 498, С. 215428 - 215428

Опубликована: Окт. 1, 2023

Язык: Английский

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Photonic control of image-guided ferroptosis cancer nanomedicine

Coordination Chemistry Reviews, Год журнала: 2023, Номер 500, С. 215532 - 215532

Опубликована: Ноя. 10, 2023

Язык: Английский

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Supramolecular assembly boosting the phototherapy performances of BODIPYs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 216054 - 216054

Опубликована: Июль 2, 2024

Язык: Английский

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BODIPY-based photocages: rational design and their biomedical application

Chemical Communications, Год журнала: 2024, Номер 60(45), С. 5770 - 5789

Опубликована: Янв. 1, 2024

This highlight reviews various strategies for constructing BODIPY-based photocages, their photodecaging mechanisms, and applications in the biomedical field.

Язык: Английский

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Glucose‐Activated Programmed Hydrogel with Self‐Switchable Enzyme‐Like Activity for Infected Diabetic Wound Self‐Adaptive Treatment

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Abstract The defective blood glucose regulation ability of diabetic patients leading to bacterial infection, cellular oxidative stress, and vascular damage results in delayed healing chronic wounds. Here, a glucose‐activated self‐switching enzyme‐like activity programmed hydrogel is proposed provide self‐regulated timely intelligent insulin release affected by fluctuations, thereby forming feedback management exerting full‐stage wound healing. composed Au─MoS 2 ─phenylboronic acid nanozyme insulin‐loaded nitroimidazole‐modified sodium alginate hypoxia‐sensitive microcapsules penylboronic‐acid‐modified chitosan. It utilizes as sacrificial agent generate antibacterial reactive oxygen species recognizing the hyperglycemia environment, releasing for up 12 h with help catalysis‐generated hypoxia environment. In normoglycemia switches supply oxygen, inhibiting further release. achieves ≈3 times recovery rate commercial dressings through improved microenvironment. has been proven significantly improve wounds regulating body's homeostasis implementing staged treatment plan, providing powerful solution care.

Язык: Английский

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