Flexible Formation of Nanoparticles: Selectively Self-Assembling with Glycoclusters to Form Nano-Photosensitizers for Multipurpose Bioimaging and Photodynamic Therapy

Molecules, Год журнала: 2025, Номер 30(6), С. 1274 - 1274

Опубликована: Март 12, 2025

The smart construction of nano-photosensitizers (PSs) is significant for multipurpose applications, such as bioimaging, efficient photodynamic anti-tumor or anti-bacterial studies. This work reports a flexible self-assembling strategy the nano-PSs, in which PSs spontaneously form amorphous aggregates killing bacteria, self-assemble with tetraphenylethene (TPE) based glycoclusters (TPE-Glc4) to construct glyco-dots cell imaging and Tricyanofuran (TCF) TPE units were bridged furan thiophene moiety two (1 2) NIR fluorescence monomers, performance aggregation-induced generation reactive oxygen species (AIG-ROS) an aggregated state. Compared large (2-a), TPE-based encapsulated PS (2-Glc) that exhibit smaller more homogeneous hydrated size approximately 40 nm, well enhanced water-solubility biocompatibility. TPE-glycoclusters facilitate cellular uptake 2 into HepG2 cells, therefore enhancing signal therapy. Meanwhile, 2-a exhibits satisfied phototoxicity against Escherichia coli. highlights self-assembly nano-PSs multifunctional bioapplications.

Язык: Английский

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A Strategy for Increasing Singlet Oxygen Quantum Yield for Water‐Soluble Distyryl‐BODIPY Derivative

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(6)

Опубликована: Май 4, 2025

ABSTRACT The combined use of synergistic therapies in photodynamic therapy has recently gained significance for achieving more effective outcomes. In recent years, ultrasound‐assisted PDT applications have begun to be investigated phthalocyanine and BODIPY derivative compounds. compounds stand out with their adjustable photophysical photochemical properties, chemical purity, singlet oxygen generation capacity. Enhancing production by through the application ultrasound appears a promising avenue advancing this treatment method. context, exploring potential sonophotochemical properties is particular interest. limited SPDT increase importance investigating Therefore, new water‐soluble distyryl‐type fluorophore having phenyl ring substituted 4‐dibenzothienyl group at meso ‐position iodines as heavy atom 2‐ 6‐positions been synthesized successfully. capacities all intermediates target product were evaluated both photochemically sonophotochemically. It was noticed that quantum yield increased remarkably light excitation

Язык: Английский

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Efficient Synthesis of Core-Fluorinated BODIPY-3,5-Diamides

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4484 - 4484

Опубликована: Май 8, 2025

A modular synthesis of a new family core-fluorinated BODIPYs was elaborated. β-Fluoro-β-nitrostyrenes were used as starting materials to prepare set mono-fluorinated pyrrole-2-amides using the Barton-Zard reaction with 2-isocyanoacetamides. The prepared monofluorinated building blocks successively transformed into corresponding dipyrromethanes and 1,7-difluoro-BODIPY-3,5-diamides. As result, luminophores combination fluorescence photosensitizing properties obtained. photophysical novel studied by UV-vis spectroscopy, cyclic voltammetry DFT calculations. In addition, their ability generate singlet oxygen assessed. 1,7-difluoro-BODIPY-3,5-diamides compared analogues reveal substituent effect at 3,5-positions. fluorescent obtained dyes significantly improved in comparison 3,5-diester analogous.

Язык: Английский

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Diketopyrrolopyrrole-Based Covalent Organic Polymer with Donor-Acceptor Structure for Efficient Near-Infrared Photothermal Conversion

Journal of Solid State Chemistry, Год журнала: 2025, Номер unknown, С. 125435 - 125435

Опубликована: Май 1, 2025

Язык: Английский

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Core-fluorinated dipyrromethanes and BODIPYs. Synthesis and study of photophysical properties

Dyes and Pigments, Год журнала: 2023, Номер 221, С. 111822 - 111822

Опубликована: Ноя. 20, 2023

Язык: Английский

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