Rapid
on-site
pathogen
detection
is
of
paramount
importance
to
prevent
widespread
bacterial
infection.
In
this
work,
we
successfully
developed
a
dual-mode
platform
based
on
horseradish
peroxidase
(HRP)
@
magnetic
zeolitic
imidazole
framework
(HMZIF).
By
using
HRP
as
biotemplate
and
an
optimal
combination
ligand
salts,
the
HMZIF
can
be
readily
obtained
through
innovative
one-pot
biomineralization
process
without
incorporation
additional
nanoparticles.
Compared
with
conventional
MOF
particles,
HMZIFs
have
smaller
particle
size
(9.19
nm),
larger
specific
surface
area,
outstanding
enrichment
capability,
superparamagnetic
behavior,
enhanced
peroxide
catalysis
activity.
Then,
integrating
turn-off
broad-spectrum
colorimetric
complementary
turn-on
fluorescent
assay
was
by
utilizing
high
activity
porous
structure
HMZIF.
The
presence
bacteria
triggered
competitive
desorption
glucose
oxidase
(GOD)
from
surface,
thereby
inhibiting
cascade
enzymatic
reaction
while
simultaneously
releasing
dye
(FAM)
aptamer-capped
micropores.
Under
conditions,
exhibited
limits
870
2300
colony-forming
units
(CFU)/mL
for
Escherichia
coli
Staphylococcus
epidermidis
in
modality
28
16
CFU/mL
modality,
respectively.
practical
applications,
fluorescence
signal
represents
concentration
indicates
total
count.
Thus,
these
two
different
types
modes,
comprehensive
assessment
liquid
quality
safety
conducted.
This
quantification
validated
real
contaminated
sewage
juice
samples
provided
general
technical
route
detecting
other
pathogenetic
replacing
aptamer,
making
it
promising
tool
monitoring
preventing
infections
environmental
food
contexts.
Abstract
Metal‐organic
frameworks
(MOFs)
are
a
new
variety
of
solid
crystalline
porous
functional
materials.
As
an
extension
inorganic
materials,
it
has
made
important
progress
in
preparation
and
application.
MOFs
widely
used
various
fields
such
as
gas
adsorption
storage,
drug
delivery,
sensing,
biological
imaging
due
to
their
high
specific
surface
area,
porosity,
adjustable
pore
size,
abundant
active
sites,
modification
by
introducing
groups.
In
this
paper,
the
types
classified,
synthesis
methods
mechanisms
materials
summarized.
Finally,
application
prospects
challenges
metal‐organic
framework
biomedical
field
discussed,
hoping
promote
multidisciplinary
fields.
eScience,
Год журнала:
2024,
Номер
4(3), С. 100231 - 100231
Опубликована: Янв. 21, 2024
Stimuli-responsive
coordination
polymers
(CPs)
are
among
one
of
the
most
prolific
research
areas
in
developing
next-generation
functional
materials.
Their
capability
being
accurately
excited
by
particular
external
changes
with
pre-determined
and
observable/characterizable
behaviours
correspond,
so
called
"stimuli"
"responsive".
Abundant
types
CP
compounds,
especially
metal-organic
frameworks
(MOFs),
rocketing
interest
owing
to
their
compositional
diversity,
structural
tunability,
essence
highly
engineerable
functionality.
This
present
review
is
aimed
sketch
several
common
stimulation
corresponding
responses
for
CPs,
accompanied
broad
logic
mechanisms
underneath.
And
further
from
aspect
material
revolution,
some
representative
progresses
together
latest
advances
CP-based
materials
various
fields
covered
attempt
display
a
broader
picture
towards
possible
prospects
this
topic.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Detecting
pathogenic
bacteria
is
crucial
for
controlling
infectious
diseases,
safeguarding
public
health,
and
ensuring
food
water
safety.
The
integration
of
metal-organic
frameworks
(MOFs)
with
aptamers
offers
a
promising
approach
to
enhance
bacterial
detection.
Aptamers
provide
high
specificity
target
recognition,
while
MOFs
contribute
tunable
porous
structures
stability,
forming
robust
biosensors.
This
synergy
improves
sensitivity,
selectivity,
versatility,
enabling
real-time
quantitative
Applications
span
safety,
environmental
monitoring,
point-of-care
diagnostics.
review
highlights
the
significance
aptamer@MOF
biosensors,
discussing
various
detection
techniques
aptamer
immobilization
methods.
It
also
addresses
challenges
like
enhancing
improving
minimizing
interference,
advancing
scalability
real-world
applications.
Additionally,
limitations
such
as
need
miniaturization,
multimode
detection,
multiplex
analysis
are
highlighted.
Future
directions
focus
on
optimizing
design
expanding
applications
overcome
these
limitations.
versatility
potential
biosensors
underscore
their
promise
high-performance
platforms
in
diverse
fields.
Applied Organometallic Chemistry,
Год журнала:
2025,
Номер
39(3)
Опубликована: Фев. 24, 2025
ABSTRACT
One
3D
Zn‐MOF
,
namely,
{[Zn
2
(L)(OH)(DMF)]}
n
was
selected
based
on
the
flexible
ether
oxygen
carboxylic
acid
3‐(3,5‐dicarboxylatobenzyloxy)benzoic
(H
3
L).
able
to
specifically
recognize
biomarker
methylmalonic
(MMA)
and
antibiotic
tetracycline
(TC)
through
fluorescence
enhancement
ratio
mechanism,
with
detection
limits
(LOD)
as
low
1.29
0.26
μM,
respectively.
It
also
has
high
selectivity
rapid
response
characteristics.
In
particular,
visual
significantly
enhanced
in
presence
of
Tb
3+
antenna
effect.
To
explore
potential
application,
fluorescent
test
strips
mixed
matrix
membrane
(MMM)
were
successfully
prepared
realize
detection.
The
recovery
rates
MMA
TC
simulated
urine
actual
water
systems
95.3%–100.5%
93.5%–94.7%,
respectively,
indicating
that
provided
possibility
for
detecting
practical
systems.
