Angewandte Chemie,
Год журнала:
2023,
Номер
136(8)
Опубликована: Ноя. 21, 2023
Abstract
Nanomedicines
are
extensively
used
in
cancer
therapy.
Covalent
organic
frameworks
(COFs)
crystalline
porous
materials
with
several
benefits
for
therapy,
including
porosity,
design
flexibility,
functionalizability,
and
biocompatibility.
This
review
examines
the
use
of
COFs
therapy
from
perspective
reticular
chemistry
function‐oriented
design.
First,
modification
sites
functionalization
methods
discussed,
followed
by
their
potential
as
multifunctional
nanoplatforms
tumor
targeting,
imaging,
integrating
functional
components.
Finally,
some
challenges
clinical
translation
presented
hope
promoting
development
COF‐based
anticancer
nanomedicines
bringing
closer
to
trials.
Metal-organic
frameworks
(MOFs)
are
composed
of
metal
nodes
and
organic
linkers
that
can
self-assemble
into
an
infinite
network.
The
high
porosity
large
surface
area
MOFs
facilitate
the
effective
enrichment
mass
transfer
analytes,
which
enhance
signal
response
improve
sensitivity
electrochemical
sensors.
Additionally,
their
derivatives
possess
properties
unsaturated
sites
tunable
structures,
collectively
demonstrating
potential
for
sensing.
This
paper
summarizes
preparation
methods,
structural
properties,
applications
in
sensing,
emphasizing
sensors'
selectivity
from
perspectives
direct
indirect
detection.
it
also
explores
future
directions
prospects
with
aim
overcoming
current
limitations
through
innovative
approaches.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(8)
Опубликована: Ноя. 21, 2023
Nanomedicines
are
extensively
used
in
cancer
therapy.
Covalent
organic
frameworks
(COFs)
crystalline
porous
materials
with
several
benefits
for
therapy,
including
porosity,
design
flexibility,
functionalizability,
and
biocompatibility.
This
review
examines
the
use
of
COFs
therapy
from
perspective
reticular
chemistry
function-oriented
design.
First,
modification
sites
functionalization
methods
discussed,
followed
by
their
potential
as
multifunctional
nanoplatforms
tumor
targeting,
imaging,
integrating
functional
components.
Finally,
some
challenges
clinical
translation
presented
hope
promoting
development
COF-based
anticancer
nanomedicines
bringing
closer
to
trials.
By
utilizing
carboxylated
multiwalled
carbon
nanotubes
(MWCNT-COOH)
to
strengthen
the
interaction
between
electrode
and
analytes
improve
conductivity
of
composite
material
in
conjunction
with
superior
catalytic
properties
copper-based
metal-organic
framework
(MOFs),
a
novel
electrochemical
sensor
was
fabricated
from
Cu-MOF/MWCNT-COOH
composite,
specifically
designed
for
simultaneous
distinct
detection
ascorbic
acid
(AA)
dopamine
(DA).
Electrochemical
analyses
were
conducted
on
innovative
through
both
CV
DPV,
revealing
unique
behaviors
AA
DA.
The
not
only
showed
exceptional
electrocatalytic
but
also
distinguished
itself
by
its
broad
dynamic
response
ranges,
covering
concentrations
3
1800
μM
2
180
DA,
limits
(S/N
=
3)
3.00
0.32
Furthermore,
this
platform
exhibited
robust
reproducibility
selectivity.
Examinations
serum
samples
yielded
recovery
rates
DA
which
101.9%
102.1%,
respectively,
confirming
sensor's
capability
perform
reliably
under
varied
biological
conditions.
findings
confirm
potential
proposed
method
simultaneous,
sensitive,
reliable
In
conclusion,
has
promising
practical
applications.
