Recent advances in copper homeostasis-involved tumor theranostics

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(5), С. 100948 - 100948

Опубликована: Сен. 7, 2024

As the third essential trace element in human body, copper plays a crucial role various physiological processes, which lays foundation for its broad applications cancer treatments. The overview of copper, including pharmacokinetics, signaling pathways, and homeostasis dysregulation, is hereby discussed. Additionally, cuproptosis, as newly proposed cell death mechanism associated with accumulation, analyzed further developed efficient treatment. Different forms Cu-based nanoparticles their advantages, well limiting factors, are introduced. Moreover, unique characteristics give rise to imaging modalities. In addition, nanomaterials featured by excellent photothermal property ROS-associated tumor-killing potential, widely explored diverse therapies combined therapies. Reducing concentration Cu

Язык: Английский

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Current advances in nanozyme-based nanodynamic therapies for cancer

Acta Biomaterialia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Metal-organic frameworks (MOFs) for phototherapy and synergistic phototherapy of cancer

Coordination Chemistry Reviews, Год журнала: 2024, Номер 526, С. 216381 - 216381

Опубликована: Дек. 10, 2024

Язык: Английский

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Nanoscale Metal‐Organic Framework Leveraging Water, Oxygen, and Hydron Peroxide to Generate Reactive Oxygen Species for Cancer Therapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Abstract Spatiotemporally increasing intracellular reactive oxygen species (ROS) level represents a promising and effective antitumor approach, but is significantly hindered by insufficient ROS sources within the tumor. Herein, Cu‐porphyrin based nanoscale metal‐organic framework (nMOF) Cu II MOF reported, which inherently integrates chemodynamic therapy (CDT), photodynamic (PDT), photocatalytic capabilities to generate storm for cancer immunotherapy. Unlike conventional porphyrin‐based MOFs, features nearly orthogonally aligned porphyrin skeletons, minimizing π–π stacking preventing self‐quenching. The Fenton‐like reaction of depletes glutathione (GSH) catalyzes H 2 O hydroxyl radical (·OH) CDT. Intriguingly, its unique topology energy levels enable photocatalyze splitting into ·OH, overcoming limitations oxygen/H dependence in PDT Moreover, reduced I MOF, formed during reaction, exhibits further enhanced lighted‐triggered generation. Thus, developed nanosheets can utilize , as source remarkable through synergetic CDT/PDT/photocatalytic combination. Both vitro vivo experiments demonstrate that spatiotemporally generated could effectively provoke ferroptosis immunogenic cell death, eliciting substantial anti‐tumor immune response

Язык: Английский

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Nanocomplex hyaluronic acid/ganciclovir@ZIF-8 for ganciclovir efficient delivery and targeted anti-KSHV treatment

Cancer Nanotechnology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 4, 2025

Язык: Английский

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