ATP‐Triggered Ultrafine Iron Oxide Nanowires for Self‐Monitoring Tumor Therapy by T₁‐Magnetic Resonance Imaging‐Guided •OH Generation

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 13, 2025

Abstract Theranostic probes that integrate diagnosis and treatment together are considered as effective tools for individual therapy. However, the separation of detection components limits precise assessment therapeutic efficacy. Herein, a novel self‐monitoring probe sensitively responds to adenosine triphosphate (ATP) was developed by ultrafine iron oxide nanowires (UIONWs) through an oleyl amine‐assisted way. The UIONWs, with diameter 1.5 nm length 75 nm, surface‐coordinated amine. UIONWs can be decomposed in ATP‐containing solution expose shielded ions. Consequently, it boost peroxidase (POD) activity activate T 1 ‐magnetic resonance imaging (MRI) signal ATP. In addition, rapidly engulfed into cells due high aspect ratio. improved ATP hydrogen peroxide (H 2 O ) within tumor leads higher hydroxyl radicals (OH) generation inhibition.In contrast, normal exhibit lower H levels, reducing cytotoxicity ensuring safety. Since both illumination ‐MRI OH ATP‐controlled, this work raised potential way self‐monitor therapy timely feedback on effects.

Язык: Английский

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Nanodiamond-Based Sensing: A revolution for biosensors in capturing elusive bio-signals in living cells

Advanced Drug Delivery Reviews, Год журнала: 2025, Номер 221, С. 115590 - 115590

Опубликована: Апрель 15, 2025

Язык: Английский

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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Bioactive Materials, Год журнала: 2023, Номер 34, С. 164 - 180

Опубликована: Дек. 26, 2023

Extracellular matrix (ECM) undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been explored. Here we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo

Язык: Английский

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PEDF-enriched extracellular vesicle for vessel normalization to potentiate immune checkpoint blockade therapy

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

The abnormal tumor vasculature acts as the physical and functional barrier to infiltration activity of effector T cells, leading low response rate immune checkpoint inhibitors (ICIs). Herein, antiangiogenic extracellular vesicles that enable normalization tumor-associated were prepared potentiate efficacy ICIs. Small exploited delivery platform protect protein, pigment epithelium-derived factor (PEDF), from proteolytic degradation. Along with physicochemical characteristics PEDF-enriched (P-EVs), their inhibitory effects on migration, proliferation, tube formation endothelial cells investigated in vitro. In tumor-bearing mice, it was confirmed that, compared bare PEDFs, P-EVs efficiently reduced vessel leakiness, improved blood perfusion, attenuated hypoxia. Consequently, when combined anti-PD-1 antibodies, remarkably augmented antitumor immunity, evidenced by increased CD8 + regulatory cells. These results suggest are promising therapeutics for tumors refractory

Язык: Английский

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A compact microfluidic laser-induced fluorescence immunoassay system using avalanche photodiode for rapid detection of alpha-fetoprotein

Analytical Sciences, Год журнала: 2024, Номер 40(7), С. 1239 - 1248

Опубликована: Апрель 10, 2024

Alpha-fetoprotein (AFP), commonly employed for early diagnosis of liver cancer, serves as a biomarker cancer screening and diagnosis. Combining the high sensitivity specificity fluorescence immunoassay (FIA), developing low-cost efficient system AFP detection holds significant importance in disease In this work, we developed miniaturized oblique laser-induced (LIF) system, coupled with microfluidic PMMA/paper hybrid chip, rapid AFP. The an avalanche photodiode (APD) detector, implemented multi-level filtering excitation light channel using dichroic mirror optical trap. At first, Savitzky–Golay filter baseline off-set elimination methods to denoise normalize original data. Then cutoff frequency low-pass reverse voltage APD were optimized enhance system. Furthermore, effect laser power on efficiency was investigated, sampling time during scanning process optimized. Finally, four-parameter logistic (4PL) model utilized establish concentration–response equation capable detecting concentrations standard solution within range 1–500 ng/mL, limit 0.8 ng/mL. entire could be completed 15 min. It has excellent potential applications portable diagnostic instruments biomarkers.

Язык: Английский

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Magnetically Actuated Nanomaterials in Biomedical Applications

Advanced NanoBiomed Research, Год журнала: 2024, Номер 4(8)

Опубликована: Июль 17, 2024

Magnetic nanomaterials, distinguished by their unique magnetic phenomena, particularly magnetically actuated capabilities, have found widespread application in the field of nanomedicine. Compared with alternative driving mechanisms, actuation as a remote, highly permeable, and precisely controllable strategy endows nanomaterials temporal spatia mobility, making it possible to initiate cease multiple forms movement vivo at will. When coupled cutting‐edge diagnostic treating techniques including but not limited resonance imaging, magnetothermal therapy, magnetoelectric stimulation, offer potential for visual analysis, provision reliable molecular information, effective disease or tissue damage intervention. This review comprehensively outlines synthesis methodologies, functional strategies, biomedical applications within Additionally, future developments biocompatible especially response time‐varying fields, are anticipated.

Язык: Английский

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Dielectrophoretic direct assembling of Mxene flakes at the level of screen-printed interdigitated microelectrodes and their evaluation in gas sensing applications

2D Materials, Год журнала: 2024, Номер 11(4), С. 045014 - 045014

Опубликована: Авг. 6, 2024

Abstract Controlling, orientating, and assembling 2D materials is critical for their successful exploitation as active elements in various applications, particularly sensors. Despite the increased interest exploiting properties of MXenes, to date, direct dielectrophoretic assembly this category has not been reported. Thus, work presents an experimental study on pristine MXene flakes at level screen-printed interdigitated microelectrodes. The development uniaxial ‘bridges’ across electrode micro-gaps can be controlled by convenient parameters such voltage frequency, which are thoroughly discussed. Moreover, appropriate frequencies avoiding parasitic electrokinetic phenomena (AC electro-osmosis, electrothermal effect) that hamper application dielectrophoresis were identified. Finally, proposed methodology demonstrates its feasibility being used chemiresistors satisfactory response ethanol atmosphere.

Язык: Английский

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A self-powered theranostic DNA nanodevice for amplification of both intracellular microRNA imaging and photodynamic therapy

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 324, С. 124987 - 124987

Опубликована: Авг. 15, 2024

Язык: Английский

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Multimodal synergistic ferroptosis cancer therapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 522, С. 216236 - 216236

Опубликована: Сен. 25, 2024

Язык: Английский

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