Versatile Peptide-Based Nanosystems for Photodynamic Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 218 - 218

Опубликована: Фев. 2, 2024

Photodynamic therapy (PDT) has become an important therapeutic strategy because it is highly controllable, effective, and does not cause drug resistance. Moreover, precise delivery of photosensitizers to tumor lesions can greatly reduce the amount administered optimize outcomes. As alternatives protein antibodies, peptides have been applied as useful targeting ligands for targeted biomedical imaging, PDT. In addition, other functionalities such stimuli responsiveness, self-assembly, activity be integrated with yield versatile peptide-based nanosystems this article, we start a brief introduction PDT nanosystems, followed by more detailed descriptions about structure, property, architecture background information. Finally, most recent advances in are emphasized summarized according peptide system reveal design development principle different circumstances. We hope review could provide insights valuable reference

Язык: Английский

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From nature to nanomedicine: bioengineered metallic nanoparticles bridge the gap for medical applications

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Май 9, 2024

Abstract The escalating global challenge of antimicrobial resistance demands innovative approaches. This review delves into the current status and future prospects bioengineered metallic nanoparticles derived from natural sources as potent agents. unique attributes abundance resources have sparked a burgeoning field research in combating microbial infections. A systematic literature was conducted, encompassing wide range studies investigating synthesis, characterization, mechanisms nanoparticles. Databases such PubMed, Scopus, Web Science, ScienceDirect, Springer, Taylor & Francis online OpenAthen were extensively searched to compile comprehensive overview topic. synthesis methods, including green sustainable approaches, examined, diverse biological used nanoparticle fabrication. amalgamation products has yielded promising Their multifaceted mechanisms, membrane disruption, oxidative stress induction, enzyme inhibition, render them effective against various pathogens, drug-resistant strains. Moreover, potential for targeted drug delivery systems using these opened new avenues personalized medicine. Bioengineered represent dynamic frontier battle underscores their remarkable efficacy action. Future are bright, with opportunities scalability cost-effectiveness through methods. However, addressing toxicity, regulatory hurdles, environmental considerations remains crucial. In conclusion, this highlights evolving landscape nanoparticles, offering valuable insights revolutionize therapy future. Graphical

Язык: Английский

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Versatile Copper-Chalcogenide-Based Nanoparticles for the Treatment of Brain Diseases

Nano Biomedicine and Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Фев. 13, 2024

The strong ethnopharmacological utilization of Isodon rugosus Wall. Ex. Benth is evident in the treatment several types pain and inflammation, including toothache, earache, abdominal pain, gastric generalized body inflammation. Based on this background, antinociceptive effects crude extract, various fractions, essential oil have been reported previously. In research work, we isolate characterize pure bioactive compounds from I. evaluate possible mechanisms using vivo vitro models. were analyzed for analgesic anti-inflammatory activities through assays. column chromatography chloroform fraction led to identification two compounds, i.e., 1 2. Compound demonstrated notable inhibition (62% writhing inhibition, 72.77% COX-2 76.97% 5-LOX inhibition) potential (>50% paw edema at intervals). mechanism involved antinociception was considered primarily, a concept that has already elucidated application naloxone (an antagonist opioid receptors). involvement adrenergic receptors investigated hot plate model receptor antagonist). ethnomedicinal background , supported by previous reports current observations, leads conclusion source compounds. It may be concluded results isolated alternative remedy inflammation management with admirable efficacy safety profiles.

Язык: Английский

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Preparation of electrochemical sensor for detection of cancer medicine doxorubicin based on multi-walled carbon nanotube composites modified electrode

Alexandria Engineering Journal, Год журнала: 2024, Номер 93, С. 51 - 58

Опубликована: Март 14, 2024

In order to create an electrochemical sensor for doxorubicin (DXB), effective cancer treatment, multi-walled carbon nanotubes—a modified glassy electrode made of mesoporous silica nanocomposite—were created in this work. Examining the mSiO2@MWCNTs nanocomposite's structure and composition using FTIR, XPS, SEM revealed combination mSiO2 MWCNTs nanostructure on surface. Studies determination DXB utilizing cyclic voltammetry (CV) differential pulse (DPV) methodologies showed that mSiO2@MWCNTs/GCE exhibited excellent sensitivity, selectivity, precision. improved work together improve sensor's overall performance by enhancing stability sensitivity oxidation DXB. The linear range was found be 30–750 μM, with a 0.05123 μA/μM detection limit 14 nM, according results. shows properties suitable real sample analysis. creation represents significant advancement field sensors may open door development more precise focused drug techniques.

Язык: Английский

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Molecular docking of bioactive compounds extracted and purified from selected medicinal plant species against covid-19 proteins and in vitro evaluation

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 14, 2024

Abstract Bioactive compounds are secondary metabolites of plants. They offer diverse pharmacological properties. Peganum harmala is reported to have pharmaceutical effects like insecticidal, antitumor, curing malaria, anti-spasmodic, vasorelaxant, antihistaminic effect. Rosa brunonii has medicinal importance in its flower and fruits effective against different diseases juice leaf be applied externally cure wounds cuts. Dryopteris ramosa aqueous extract used treat stomach ulcers stomachaches. Each these three plants been indicated anticancer, antiviral, antioxidant, cytotoxic antifungal but efficacy their bioactive remained unexplored. Study was aimed explore In-vitro In-silico above DPPH ABTS assay were for assessment antioxidant properties compounds. Antibacterial checked by agar well diffusion method. Brine shrimp lethality performed check effect Molecular docking conducted investigate the binding between isolated targeted proteins. The compound isomangiferrin tiliroside presented strong potential 78.32% (± 0.213) 77.77% 0.211) respectively while harmaline showed 80.71% 0.072) at 200 µg/mL assay. harmine, PH-HM 17 exhibited highest zone inhibition 22 mm, 23 mm Xanthomonas Irriflophenone-3-C-β- D-glucopyranoside maximum 34 E. coli. vasicine contained antibacterial activity 32 S. aureus. mangiferrin, astragalin, tiliroside, quercitin-3-O-rhamnoside inhibitory 26 24 Klebsiella pneumoniae. Highest observed i.e. 95% with LD 50 value 73.59 µg/mL. best mode interaction all proteins presenting hydrophobic interactions hydrogen bonds. affinity − 17.9, 14.9, 14.6, 13.8, 12.8 6VAR, 5C5S, IEA3, 2XV7 6LUS respectively. significant natural antioxidants, which could help prevent progression various caused free radicals. Based on molecular we concluded that phytochemicals can better anticancer antiviral potential.

Язык: Английский

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Formulation and evaluation of anti-osteoarthritic, cytotoxicity and antioxidant effects of carbon dots derived Allium sativum L. leaf extract

Alexandria Engineering Journal, Год журнала: 2024, Номер 92, С. 231 - 237

Опубликована: Март 6, 2024

The fabrication of carbon nanostructured material for biomedical application has gained a lot interest in recent years. Herein, the preparation dots (CDs) using Allium sativum L. leaf extract were demonstrated hydrothermal process. CDs characterized various techniques including UV-Vis, DLS, FT-IR, XPS and TEM methods. green synthesized mostly spherical with diameter 2.1 ±0.6 nm high colloidal stability. Good antioxidant activity versus DPPH was observed prepared CDs. Furthermore, cytotoxicity effect investigated MTT strategy. Moreover, applied as scavengers reactive oxygen species osteoarthritis (OA). For clinical applications, source positive effects terms antioxidant, anti-osteoarthritis, properties. obtained results have potential to offer fresh perspectives on treatment different inflammatory diseases caused by species. Additionally, used determine Fe(III) fluorescence (FL) procedure. decrease FL intensity allowed measure wide linear range (10 nM-0.5 mM) low detection limit 4.0 nM. These findings show that great applications.

Язык: Английский

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Amyloid detection in neurodegenerative diseases using MOFs

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(19), С. 4553 - 4573

Опубликована: Янв. 1, 2024

Neurodegenerative diseases (amyloid such as Alzheimer's and Parkinson's), stemming from protein misfolding aggregation, encompass a spectrum of disorders with severe systemic implications. Timely detection is pivotal in managing these owing to their significant impact on organ function high mortality rates. The diverse array amyloid disorders, spanning localized manifestations, underscores the complexity conditions highlights need for advanced methods. Traditional approaches have focused identifying biomarkers using imaging techniques (PET MRI) or invasive procedures. However, recent efforts use metal-organic frameworks (MOFs), versatile class materials known unique properties, revolutionizing disease detection. porosity, customizable structures, biocompatibility MOFs enable integration biomolecules, laying groundwork highly sensitive specific biosensors. These sensors been employed electrochemical photophysical that target species under neurodegenerative conditions. adaptability allows precise quantification proteins, offering potential advancements early diagnosis management. This review article delves into how contribute detecting by categorizing uses based different sensing methods, (EC), electrochemiluminescence (ECL), fluorescence, Förster resonance energy transfer (FRET), up-conversion luminescence (ULRET), photoelectrochemical (PEC) sensing. drawbacks MOF biosensors challenges encountered field are also briefly explored our perspective.

Язык: Английский

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Nano revolution in cardiovascular health: Nanoparticles (NPs) as tiny titans for diagnosis and therapeutics

Current Problems in Cardiology, Год журнала: 2024, Номер 49(5), С. 102466 - 102466

Опубликована: Фев. 16, 2024

Язык: Английский

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Isolation and nanoformulation of mucilage from Abelmoschus esculentus (okra) biomass and evaluation of its biological activities and biocompatibility

Biomass Conversion and Biorefinery, Год журнала: 2024, Номер unknown

Опубликована: Май 8, 2024

Язык: Английский

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