Vidyodaya Journal of Science,
Год журнала:
2024,
Номер
27(02)
Опубликована: Дек. 30, 2024
Nanozymes,
artificial
nanomaterials
mimicking
enzyme
activity,
are
at
the
forefront
of
innovative
cancer
therapies,
particularly
in
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
and
photothermal
(PTT).
Their
capacity
to
selectively
generate
reactive
oxygen
species
under
tumor-specific
conditions,
including
low
pH
high
H₂O₂
levels,
facilitates
targeted
induction
cell
death
while
minimizing
damage
healthy
tissues.
When
integrated
with
PDT
or
PTT,
nanozymes
enhance
oxidative
stress
promote
immunogenic
death,
further
amplifying
anti-tumor
immune
responses.
Recent
advances
single-atom
intelligent
have
shown
promise
overcoming
therapeutic
limitations,
such
as
tumor
hypoxia
suppression
modulating
microenvironment
boost
treatment
efficacy.
Additionally,
ongoing
preclinical
clinical
evaluations
highlight
potential
synergistically
immunotherapy
outcomes.
advantages
over
traditional
enzymes,
stability,
tunability,
cost-effectiveness,
ability
maintain
catalytic
activity
hostile
environments,
position
transformative
agents
therapy.
However,
their
translation
faces
significant
challenges,
biocompatibility
concerns,
delivery
inefficiencies
sites,
stringent
regulatory
hurdles,
which
require
comprehensive
research
solutions
address.
Despite
these
advancements
nanozyme
design
functionalization
continue
pave
way
for
more
effective
safer
applications
will
be
discussed
detail
this
review.Keywords:
Cancer
therapy,
Nanomaterial,
ROS,
(PTT)
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(1), С. 4 - 4
Опубликована: Янв. 31, 2025
Regrettably,
despite
undeniable
advances
in
cancer
diagnosis
and
therapy,
primary
brain
(or
cancer)
remains
one
of
the
deadliest
forms
malignant
tumors,
where
glioblastoma
(GBM)
is
known
as
most
diffuse
glioma
astrocytic
lineage.
Fortunately,
to
improve
this
scenario,
remarkable
progress
nanotechnology
has
brought
new
promise
raised
expectations
treatment.
Nanomedicine,
principally
an
area
amalgamating
with
biology
medicine,
demonstrated
a
pivotal
role,
starting
earliest
detection
while
also
offering
novel
multimodal
therapy
alternatives.
In
vast
realm
nanotechnology,
nanozymes,
type
nanomaterial
intrinsic
enzyme-like
activities
characteristics
connecting
fields
nanocatalysts,
enzymology,
biology,
have
emerged
powerful
nanotools
for
theranostics.
Hence,
fascinating
field
research
experienced
exponential
growth
recent
years.
As
it
virtually
impossible
cover
all
literature
on
broad
domain
science
paper,
review
focuses
presenting
multidisciplinary
approach,
its
content
extending
from
fundamental
knowledge
nanozymes
enzyme-mimicking
catalysis
targeting
cancers.
Although
we
are
at
very
early
stages
research,
can
be
envisioned
that
strategic
development
theranostics
will
positively
offer
disruptive
nanoplatforms
future
nano-oncology.
In
this
study,
a
composite
comprising
rare‐earth
metal,
samarium
vanadate
(SmVO
4
,
SmV),
anchored
to
halloysite
nanotube
(HNT)
making
SmV/HNT
nanocomposite
is
synthesized
for
the
sensitive
electrochemical
determination
of
furaltadone
(FLD)
through
differential
pulse
voltammetry
analysis
based
on
synergistic
effect
(the
catalytic
activity
and
chemical
stability
SmV,
which
was
further
boosted
by
improved
surface
area
conductance
HNT).
Further,
in
microscopic
studies,
it
revealed
that
SmV
exhibits
tetragonal
zircon‐type
crystalline
structure,
with
I4
1
/
amd
(141)
space
group,
whereas
HNT
comprises
multiphase
kaolin
composition
as
gibbsite‐like
octahedral
sheet
multivalency,
morphological
irregularities
individual
constituents
are
rectified
composite.
The
spray‐coated
polyethylene
terephthalate
sheet,
delivered
promising
trace
level
limit
detection
(0.009
μ
m
)
over
wide
working
range
(0.05–194.4
FLD.
Furthermore,
real
sample
performed
using
human
serum,
pharmaceutical
tablet
results
reveal
exceptional
repeatability
sensitivity,
indicating
real‐time
application
domain.
Ulcerative
colitis
(UC)
involves
persistent
inflammation
in
the
colon
and
rectum,
with
excessive
reactive
oxygen
species
(ROS)
accumulation.
This
ROS
buildup
damages
colonic
epithelial
cells
disrupts
intestinal
flora,
worsening
disease
progression.
Current
antioxidant
therapies
are
limited
due
to
their
instability
gut
lack
of
targeting,
hindering
precise
intervention
at
lesion
site.
study
prepares
an
L-Arginine-modified
selenium
nanozyme
(Se-CA)
for
targeted
oral
treatment
UC.
Se-CA
specifically
targets
M1-type
macrophages
sites
by
binding
cationic
amino
acid
transporter
protein
2
on
surface
macrophages.
In
vitro
studies
show
that
scavenges
nitrogen
(RNS)
artificial
gastric
fluids,
inhibits
iron
death
cells.
mice
model
ulcerative
colitis,
administration
is
effective
through
its
anti-inflammatory
properties,
inhibition
regulation
flora.
conclusion,
this
work
provides
new
insights
into
Nanoscale Advances,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Cancer
is
a
leading
cause
of
death
globally,
and
traditional
treatment
methods
often
come
with
non-negligible
toxic
side
effects
in
its
treatment,
threatening
patients'
quality
life.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Piezoelectric
semiconductor
nanomaterials
have
attracted
considerable
interest
in
piezocatalytic
tumor
treatment.
However,
therapy
encounters
obstacles
such
as
suboptimal
piezoelectric
responses,
rapid
electron‐hole
recombination,
inefficient
energy
harvesting,
and
the
complexities
of
microenvironment.
In
this
study,
sulfur
vacancy‐engineered
cobalt
(Co)
single‐atom
doped
molybdenum
disulfide
(SA‐Co@MoS
2
)
nanoflowers
are
strategically
designed,
which
exhibit
enhanced
effects.
Specifically,
introduction
Co
single
atom
not
only
induces
lattice
distortion
out‐of‐plane
polarization
but
also
leads
to
formation
numerous
vacancies.
These
changes
collectively
narrow
intrinsic
bandgap
material,
facilitating
effective
separation
migration
charge
carriers,
enabling
efficient
production
reactive
oxygen
species
under
ultrasound
stimulation.
Additionally,
SA‐Co@MoS
demonstrate
improved
enzymatic
activity
glutathione
depletion
capabilities
attributed
mixed
valence
states
Co,
intensifying
oxidative
stress
cells,
leading
cell
cycle
arrest
apoptosis,
while
inactivation
peroxidase
4
ferroptosis.
Both
vitro
vivo
results
indicate
that
can
significantly
eliminate
cells.
This
study
offers
valuable
insights
into
exploration
doping‐enhanced
sonosensitizers
for
cancer
treatment,
potentially
paving
way
advancements
field
synergistic
enzyodynamic
therapy.
