Talanta, Год журнала: 2024, Номер 281, С. 126860 - 126860
Опубликована: Сен. 10, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216549 - 216549
Опубликована: Фев. 27, 2025
Язык: Английский
Процитировано
0
Science China Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
Язык: Английский
Процитировано
0
ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Gadolinium functionalized carbon dot complexes (Gd-CDs) have both the fluorescent properties of dots and magnetic characteristics gadolinium ions, exhibiting excellent biocompatibility, high spatial resolution, sensitivity, deep tissue penetration in bioimaging. As fluorescence (FL) resonance imaging (MRI) probes, Gd-CDs attracted significant attention dual-modal biological imaging. This review summarizes recent advances Gd-CDs, focusing on their structure, optical properties, applications First, according to different existing forms dots, structures are categorized into chelation, electrostatic interaction, encapsulation. Second, mechanisms performances introduced detail. The reported a maximum quantum yield 69.86%, with emission wavelength reaching up 625 nm, optimum longitudinal transverse relaxivity rates 35.39 115.6 mM-1 s-1, respectively, showing FL/MRI capacities. Subsequently, progress cellular imaging, vivo integrated cancer diagnosis therapy is reviewed. Finally, challenges issues faced by development summarized, providing new insights for controlled synthesis widespread application biomedical field
Язык: Английский
Процитировано
0
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Leveraging disulfide (-S-S-) or diselenide (-Se-Se-) units as triggers in the design of small-molecule fluorescent probes for detecting intracellular reductive species has demonstrated high efficacy. However, selenenylsulfides, which exhibit reactivity between diselenides and disulfides, remain relatively unexplored. In this work, we compare efficiency -S-S-, seleno-sulfur (-Se-S-), sulfur-selenium (-S-Se-) structural constructing thiol probes, disclose scaffold -Se-S- a versatile recognition site thiols, successfully apply unit to near-infrared (NIR) probe, ASC-SeS. The mechanism reveals that breaking bond leads selenolate, undergoes faster cyclization than corresponding thiolate is from cleavage -S-S- -S-Se- bond. Conjugation trigger with multiple NIR fluorophores validates general applicability linear selenenylsulfides accelerating response rate thiols. By harnessing superior responsiveness ASC-SeS, employ probe live cells vivo, elucidate severe depletion thiols drug-induced liver injury (DILI).
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216608 - 216608
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0
Food Chemistry, Год журнала: 2025, Номер unknown, С. 144041 - 144041
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Abstract The precise detection of multiple microRNAs (miRNAs) is great significance to the classification various cell subtypes. However, miRNA hindered by signal leakage, false‐positive signals and low expression miRNAs. Herein, a DNA nanodevice in second near infrared region (NIR‐II, 1000‐1700 nm) (DND‐II) developed for dual miRNAs bioimaging based on “AND” logic‐gate amplification strategy. spatiotemporally controlled logic‐gate‐based DND‐II fabricated thermosensitive liposomes integrated with near‐infrared probes. In particular, “always‐on” photoacoustic probes provided an additional imaging tool monitor distribution vivo. When both are present, generated “turn on” fluorescent through logical analysis molecular computation, further triggering entropy‐driven dual‐cycle fluorescence amplification. spatiotemporal provides powerful platform early diagnosis photothermal ablation different subtypes tumor cells.
Язык: Английский
Процитировано
0
ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Abstract Hydrogen sulfide (H 2 S) is a vital gaseous signaling molecule that plays central role in various physiological and pathological processes. Given the complementary advantages of fluorescence (FL) photoacoustic (PA) imaging, there growing demand for dual‐ratiometric probes enable precise vivo monitoring H S levels. In this study, use 2‐mercapto‐1,3,4‐thiadiazole (MTD) as novel recognition group presented first time, following conjugation with cyanine dyes to obtain new PA probe Cy‐MTD. To achieve Cy‐MTD incorporated into down‐conversion nanoparticle (DCNP), resulting creation pioneering NIR‐II FL/NIR‐I nanoprobe DCNP@Cy‐MTD. undergoes blueshift absorption from 840 670 nm after reaction S, enabling NIR‐I ratiometric imaging by measuring ratio signal at (PA /PA ). addition, due strong ≈840 overlapping between spectrum 808 excitation band DCNP, nm‐excited FL emission (F 1550 nm,808Ex ) DCNP DCNP@Cy‐MTD quenched through competitive absorption, while it restored upon interaction because Using stable under 980 nm,980Ex reference signal, /F achieved. The response features offer significant advancement over traditional single‐signal or single‐modality techniques. By providing enhanced accuracy reliability, allows diagnosis hepatitis surpassing capabilities conventional histopathological methods, which provides way more effective diagnostic strategies liver diseases.
Язык: Английский
Процитировано
0
Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 13, 2024
Hydrogen persulfide (H
Процитировано
3