SWCNTs functionalized with gold nanoradiosensitizers as radiosensitizers for enhanced radiotherapy in breast cancer

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102113 - 102113

Опубликована: Фев. 1, 2025

Язык: Английский

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Chalcogen Modification: One-Step Strategy for Tuning the Photophysical Properties and NIR Phototherapy of Iodinated BODIPY

Materials Chemistry Frontiers, Год журнала: 2024, Номер 8(20), С. 3308 - 3320

Опубликована: Янв. 1, 2024

A schematic illustration of iodinated BODIPY based on chalcogen modification the photophysical properties for near-infrared phototherapy tumors.

Язык: Английский

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CrO3-doped P2O5-KF-Al2O3 glasses for NIR light-emitting devices: Crystalline field evaluation via Tanabe-Sugano diagram and investigation of the nephelauxetic effect

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141616 - 141616

Опубликована: Янв. 1, 2025

Язык: Английский

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Stealth Nanoparticles with a “Self-Consuming” Shell for Long-Term Blood Vessel Imaging

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 16, 2025

The development of lanthanide-doped upconversion nanoparticle (UCNP)-based imaging with minimal autofluorescence and improved penetration depth is important in medical applications. Exogenous nanocarriers readily adsorb plasma proteins following intravenous administration (<0.5 min), resulting the formation a protein corona on fixed surface. facilitates UCNP interception by immune system, preventing targeted delivery to disease sites. In this study, we report novel surface-camouflaging strategy using lanthanide hydroxyl carbonate that slowly dissolved physiological phosphate serum. "self-consuming" inorganic-shell-modified UCNPs (denoted as UCSP-PEG) effectively reduce adhesion more than 90% through dissociation effect associated amphiphilic poly(ethylene glycol) (PEG)-modified determined an ex vivo assay. UCSP-PEG exhibits prolonged blood circulation time (t1/2 = 73.9 ± 9.5 185 times camouflage materials without "stealth" feature, can employ upconverted luminescence (UCL) monitor tumor-related vessels for at least 120 min. Based superior optical properties UCSP-PEG, application UCL dual-channel stereoscope magnification system has enabled observation capillaries high resolution, offering powerful tool monitoring biological activities fine tissue level. This work provides nanovehicle, resisting based significantly advance target-specific cancer diagnosis.

Язык: Английский

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Biodegradable Persistent Luminescence Nanoparticles as Pyroptosis Inducer for High‐Efficiency Tumor Immunotherapy

Advanced Science, Год журнала: 2024, Номер 11(39)

Опубликована: Авг. 19, 2024

Abstract Pyroptosis possesses potent antitumor immune activity, making pyroptosis inducer development a promising direction for tumor immunotherapy. Persistent luminescence nanoparticles (PLNPs) are highly sensitive optical probes extensively employed in diagnosis and therapy. However, based on PLNPs has not been reported yet. Herein, polyethylene glycol–poly lactic acid‐co‐glycolic acid (PEG–PLGA: PP) modified biodegradable CaS:Eu 2+ (CSE@PP) synthesized as immunotherapy the first time. The CSE@PP biowindow persistent (PersL) pH‐responsive degradation properties, allowing it to remain stable under neutral pH but degrade when exposed weak (pH < 6.5). During within tumor, constantly releases H 2 S Ca while its PersL gradually fades away. Thus, signal can self‐monitor release. Furthermore, released result mitochondrial dysfunction inactivation of reactive oxygen species scavenging enzymes, synergistic facilitating intracellular oxidative stress, which induces caspase‐1/GSDM‐D dependent subsequent responses. In word, is confirmed that release pyroptosis‐mediated Immunotherapy. This work will facilitate biomedical applications inspire pyroptosis‐induced

Язык: Английский

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Instant in situ highlighting of latent fingerprints by a green fluorescent probe based on aggregation-induced emission

Biosensors and Bioelectronics, Год журнала: 2024, Номер 263, С. 116572 - 116572

Опубликована: Июль 14, 2024

Язык: Английский

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Dimeric PD-L1 specific affibody grafted Fe-based nanosheets for tumor-targeting dual-mode magnet resonance imaging and enhancement of Photothermal-Immunotherapy

Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159400 - 159400

Опубликована: Янв. 9, 2025

Язык: Английский

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BDT mediated asymmetric deposition of Ag on gold nanobipyramids for SERS detection of drug residues in aquaculture water

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер 713, С. 136558 - 136558

Опубликована: Март 3, 2025

Язык: Английский

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Functionalized recycled polyethylene terephthalate plastic by rare earth oxide for electronic device and housing infrastructure applications

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 24, 2025

Abstract Recycled polyethylene terephthalate (RPET) was doped with Neodymium Oxide (Nd 2 O 3 : 0, 1, 2, 4, and 8 wt.%) to investigate its structural, optical, dielectric, mechanical properties. X-ray diffraction (XRD) analysis revealed that pure RPET exhibited an amorphous structure, while the incorporation ofNd induced formation of crystalline phases, crystallinity increasing as Nd concentration increased. Fourier-transform infrared (FTIR) spectroscopy identified chemical interactions between , evidenced by a new band around 535 cm −1 . Optical using diffuse reflectance UV–Vis showed reduction in gap from 3.75 eV for 2.25 8wt.% samples, indicating enhanced optical Dielectric studies doping significantly decreased dielectric constant RPET, contributing thermal stability constant. Furthermore, loss conductivity improved, observed across varying temperatures. Dynamic (DMA) adding wt.% reduced storage modulus 1.62 GPa approximately 0.26 at 35 °C, attributed structural softening. These improvements suggest -doped is suitable applications requiring conductive REPT, low modulus, stability, energy dissipation capabilities.

Язык: Английский

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Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Advanced NanoBiomed Research, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Lanthanide‐based luminescence nanothermometry has demonstrated unprecedented advantages in the development of nanotheranostic platforms for potential medical applications, yet despite exponential research progress and great enthusiasm across various related disciplines, a swift bench‐to‐bedside translation seems to be still out reach. This is predominantly fundamental issues at preclinical stage, such as complex nanomaterials design, incomplete optimization, fragmented characterization, insufficient validation nanothermometer performance physiological environments. The main impediments currently are important biophysicochemical that must addressed comprehensively, first foremost available vitro systems, before going on vivo investigations. review outlines critical perspective, well route suggestions underexplored aspects address significantly minimize existing translational gap.

Язык: Английский

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