Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141174 - 141174
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 141174 - 141174
Опубликована: Дек. 1, 2024
Язык: Английский
Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102113 - 102113
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2Materials Chemistry Frontiers, Год журнала: 2024, Номер 8(20), С. 3308 - 3320
Опубликована: Янв. 1, 2024
A schematic illustration of iodinated BODIPY based on chalcogen modification the photophysical properties for near-infrared phototherapy tumors.
Язык: Английский
Процитировано
9Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141616 - 141616
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 16, 2025
The development of lanthanide-doped upconversion nanoparticle (UCNP)-based imaging with minimal autofluorescence and improved penetration depth is important in medical applications. Exogenous nanocarriers readily adsorb plasma proteins following intravenous administration (<0.5 min), resulting the formation a protein corona on fixed surface. facilitates UCNP interception by immune system, preventing targeted delivery to disease sites. In this study, we report novel surface-camouflaging strategy using lanthanide hydroxyl carbonate that slowly dissolved physiological phosphate serum. "self-consuming" inorganic-shell-modified UCNPs (denoted as UCSP-PEG) effectively reduce adhesion more than 90% through dissociation effect associated amphiphilic poly(ethylene glycol) (PEG)-modified determined an ex vivo assay. UCSP-PEG exhibits prolonged blood circulation time (t1/2 = 73.9 ± 9.5 185 times camouflage materials without "stealth" feature, can employ upconverted luminescence (UCL) monitor tumor-related vessels for at least 120 min. Based superior optical properties UCSP-PEG, application UCL dual-channel stereoscope magnification system has enabled observation capillaries high resolution, offering powerful tool monitoring biological activities fine tissue level. This work provides nanovehicle, resisting based significantly advance target-specific cancer diagnosis.
Язык: Английский
Процитировано
1Advanced Science, Год журнала: 2024, Номер 11(39)
Опубликована: Авг. 19, 2024
Abstract Pyroptosis possesses potent antitumor immune activity, making pyroptosis inducer development a promising direction for tumor immunotherapy. Persistent luminescence nanoparticles (PLNPs) are highly sensitive optical probes extensively employed in diagnosis and therapy. However, based on PLNPs has not been reported yet. Herein, polyethylene glycol–poly lactic acid‐co‐glycolic acid (PEG–PLGA: PP) modified biodegradable CaS:Eu 2+ (CSE@PP) synthesized as immunotherapy the first time. The CSE@PP biowindow persistent (PersL) pH‐responsive degradation properties, allowing it to remain stable under neutral pH but degrade when exposed weak (pH < 6.5). During within tumor, constantly releases H 2 S Ca while its PersL gradually fades away. Thus, signal can self‐monitor release. Furthermore, released result mitochondrial dysfunction inactivation of reactive oxygen species scavenging enzymes, synergistic facilitating intracellular oxidative stress, which induces caspase‐1/GSDM‐D dependent subsequent responses. In word, is confirmed that release pyroptosis‐mediated Immunotherapy. This work will facilitate biomedical applications inspire pyroptosis‐induced
Язык: Английский
Процитировано
6Biosensors and Bioelectronics, Год журнала: 2024, Номер 263, С. 116572 - 116572
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
5Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159400 - 159400
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
0Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер 713, С. 136558 - 136558
Опубликована: Март 3, 2025
Язык: Английский
Процитировано
0Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 24, 2025
Abstract Recycled polyethylene terephthalate (RPET) was doped with Neodymium Oxide (Nd 2 O 3 : 0, 1, 2, 4, and 8 wt.%) to investigate its structural, optical, dielectric, mechanical properties. X-ray diffraction (XRD) analysis revealed that pure RPET exhibited an amorphous structure, while the incorporation ofNd induced formation of crystalline phases, crystallinity increasing as Nd concentration increased. Fourier-transform infrared (FTIR) spectroscopy identified chemical interactions between , evidenced by a new band around 535 cm −1 . Optical using diffuse reflectance UV–Vis showed reduction in gap from 3.75 eV for 2.25 8wt.% samples, indicating enhanced optical Dielectric studies doping significantly decreased dielectric constant RPET, contributing thermal stability constant. Furthermore, loss conductivity improved, observed across varying temperatures. Dynamic (DMA) adding wt.% reduced storage modulus 1.62 GPa approximately 0.26 at 35 °C, attributed structural softening. These improvements suggest -doped is suitable applications requiring conductive REPT, low modulus, stability, energy dissipation capabilities.
Язык: Английский
Процитировано
0Advanced NanoBiomed Research, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Lanthanide‐based luminescence nanothermometry has demonstrated unprecedented advantages in the development of nanotheranostic platforms for potential medical applications, yet despite exponential research progress and great enthusiasm across various related disciplines, a swift bench‐to‐bedside translation seems to be still out reach. This is predominantly fundamental issues at preclinical stage, such as complex nanomaterials design, incomplete optimization, fragmented characterization, insufficient validation nanothermometer performance physiological environments. The main impediments currently are important biophysicochemical that must addressed comprehensively, first foremost available vitro systems, before going on vivo investigations. review outlines critical perspective, well route suggestions underexplored aspects address significantly minimize existing translational gap.
Язык: Английский
Процитировано
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