Advancements in platinum-based anticancer drug development: A comprehensive review of strategies, discoveries, and future perspectives
Debsankar Sahoo,
Priya Deb,
Tamal Basu
и другие.
Bioorganic & Medicinal Chemistry,
Год журнала:
2024,
Номер
112, С. 117894 - 117894
Опубликована: Авг. 23, 2024
Язык: Английский
Recent advances in ruthenium（III） complex-loaded nanomaterial for enhanced cancer therapy efficacy
Drug Development and Industrial Pharmacy,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Янв. 21, 2025
Objective
Amid
the
escalating
global
cancer
incidence,
development
of
effective
and
safe
anticancer
drugs
is
a
critical
priority
in
medical
research.
Addressing
clinical
shortcomings
ruthenium-based
are
currently
prominent
focus
Язык: Английский
The outcast of medicine: metals in medicine--from traditional mineral medicine to metallodrugs
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 7, 2025
Metals
have
long
held
a
significant
role
in
the
human
body
and
been
utilized
as
mineral
medicines
for
thousands
of
years.
The
modern
advancement
metals
pharmacology,
particularly
metallodrugs,
has
become
crucial
disease
treatment.
As
machanism
metallodurgsare
increasingly
uncovered,
some
metallodrugs
are
already
approved
by
FDA
widely
used
treating
antitumor,
antidiabetes,
antibacterial.
Therefore,
thorough
understanding
metallodrug
development
is
essential
advancing
future
study.
This
review
offers
an
in-depth
examination
evolution
applications
within
contemporary
medicine.
We
specifically
aim
to
summarize
historical
trajectory
Traditional
Chinese
Mineral
Medicine
analyzing
key
texts
representative
medicines.
Additionally,
we
discuss
recent
advancements
metallodrugs’
mechanisms,
such
protein
interactions,
enzyme
inhibition,
DNA
reactive
oxygen
species
(ROS)
generation,
cellular
structure
targeting.
Furthermore,
address
challenges
propose
potential
solutions.
Lastly,
outline
directions
enhance
their
efficacy
effectiveness.
progression
broadened
contributed
significantly
patient
health,
creating
good
healthcare
solutions
global
population.
Язык: Английский
Synthesis and Evaluation of amyloid beta peptide/ Ruthenium III -based complex drugs as drug delivery and anticancer activity
Toxicology Reports,
Год журнала:
2024,
Номер
13, С. 101778 - 101778
Опубликована: Окт. 18, 2024
The
development
and
characterization
of
anticancer
complex
drugs
(ACD),
specifically
Amyloid
Beta
Peptide
(ABP)
-
Ruthenium
III
(Ru
III)
nivolumab
(NB),
were
explored
through
analytical
techniques.
Fourier-transform
infrared
(FTIR)
spectroscopy
demonstrated
the
structural
transformation
peptides
from
α-helical
to
β-sheet
formations,
aligning
with
amyloid
fibril
aggregation.
(III)
synthesis
was
confirmed
distinct
absorption
peaks
in
FTIR
analysis.
High-resolution
scanning
electron
microscopy
(HRSEM)
revealed
fibrous
smooth
morphology
ACD,
while
thermogravimetric
analysis
(TGA)
decomposition
stages
stability
ruthenium
complexes.
encapsulation
efficiency
vitro
release
profile
(NB)
within
ABP-RuIII-NB
investigated,
showing
a
two-phase
over
40
h.
Cytotoxicity
studies
using
acridine
orange
ethidium
bromide
staining
techniques
indicated
significant
apoptosis
human
oral
squamous
cell
carcinoma
(OSCC)
-treated
cells.
These
findings
highlight
potential
as
an
effective
cancer
treatment
controlled
drug
high
cytotoxicity
against
Язык: Английский
Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy
Drug Development Research,
Год журнала:
2024,
Номер
85(8)
Опубликована: Дек. 1, 2024
ABSTRACT
The
development
of
anticancer
drugs
that
target
different
organelles
has
received
extensive
attention
due
to
the
characteristics
cancer
recurrence,
metastasis,
and
drug
resistance.
endoplasmic
reticulum
(ER)
is
an
important
structure
within
cell
primarily
responsible
for
protein
synthesis,
folding,
modification,
transport
plays
a
crucial
role
in
function
health.
ER
stress
activation
induces
apoptosis.
New
with
mechanisms
selectivity
can
be
designed
because
redox
activity,
composition
diversity,
metal
complexes
regulation.
Over
past
few
decades,
dozens
have
killed
cells
through
stress,
showing
powerful
tumor‐suppressive
effects.
This
review
summarizes
progress
research
on
metallic
induce
over
years,
which
expected
bring
more
breakthroughs
field
medicine
life
science.
Язык: Английский