A Non-Solvatochromic Fluorescent Probe for Imaging of Lipid Droplets in Live Cells and Tissues

Talanta, Год журнала: 2025, Номер 290, С. 127805 - 127805

Опубликована: Фев. 22, 2025

Язык: Английский

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Fungal detection and elimination based on AIEgens

Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216548 - 216548

Опубликована: Фев. 26, 2025

Язык: Английский

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Acceptor Elongation Boosted Intersystem Crossing Affords Efficient NIR Type‐I and AIE‐Active Photosensitizers for Targeting Ferroptosis‐Based Cancer Therapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Photosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation‐induced emission (AIE) activity offer a promising solution to achieve non‐invasive precise theranostics. However, the reported AIE luminogens (AIEgens) with both characteristic strong type‐I ROS are still scarce structure‐property relationship is unclear. Herein, an innovative acceptor elongation boosted intersystem crossing (AEBIC) design strategy has been proposed endow AIEgen producibility. The results indicate that obtained exhibit aggregation‐enhanced efficacy, which verified by experimental theoretical results. Mechanistic study reveal promoted dual‐channel pathway enhance (ISC) process due differences in triplet configurations, can be further amplified aggregation. afforded AIE‐PS show lipid droplet‐anchored induce ferroptosis through destroying cellular redox homeostasis increasing lethal levels of peroxidation. Finally, targeting ferroptosis‐based cancer therapy realized excellent anti‐tumor effect.

Язык: Английский

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A Solvatochromic and Photosensitized Lipid Droplet Probe Detects Local Polarity Heterogeneity and Labels Interacting Proteins in Human Liver Disease Tissue

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract The intricate morphology, physicochemical properties, and interacting proteins of lipid droplets (LDs) are associated with cell metabolism related diseases. To uncover these layers information, a solvatochromic photosensitized LDs‐targeted probe based on the furan‐based D‐D‐π‐A scaffold is developed to offer following integrated functions. First, turn‐on fluorescence upon selectively binding LDs allows for direct visualization their location morphology. Second, its linear correlation polarity quantifies micro‐environmental heterogeneity among LDs. Third, unique properties enable photocatalytic proximity labeling enrichment LDs‐interacting proteins, ready potential downstream proteomic analysis. These functions exemplified using artificial in buffer, stressed liver line, diseased tissues biopsied from patients. While most LD sensors only imaging functions, multi‐functional reported herein integrates both singlet triplet photosensitization studies.

Язык: Английский

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Rationally Designed Maleimide Dyes for Large Stokes Shifted Solvatochromism and Aggregation-Induced Emission

Journal of Fluorescence, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Язык: Английский

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Regulating the hydrophobic part in amphiphilic triphenylamino-diarylethene fluorophores for ultrasensitive and portable detection of urinary albumin

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137592 - 137592

Опубликована: Март 1, 2025

Язык: Английский

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ACQ-to-AIE Modulation through Delicate Donor-Acceptor Switch Strategy for Multi-functional AIEgens Applications

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112750 - 112750

Опубликована: Март 1, 2025

Язык: Английский

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A ratiometric fluorescent probe with favorable water solubility based on coumarin unit for ultrafast detection of SO2 derivatives (SO32-/HSO3-) and its bioimaging

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142268 - 142268

Опубликована: Апрель 1, 2025

Язык: Английский

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Fluorescent probes in autoimmune disease research: current status and future prospects

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 9, 2025

Autoimmune diseases (AD) present substantial challenges for early diagnosis and precise treatment due to their intricate pathogenesis varied clinical manifestations. While existing diagnostic methods strategies have advanced, sensitivity, specificity, real-time applicability in settings continue exhibit significant limitations. In recent years, fluorescent probes emerged as highly sensitive specific biological imaging tools, demonstrating potential AD research.This review examines the response mechanisms historical evolution of various types probes, systematically summarizing latest research advancements application autoimmune diseases. It highlights key applications biomarker detection, dynamic monitoring immune cell functions, assessment drug efficacy. Furthermore, this article analyzes technical currently encountered probe development proposes directions future research. With ongoing materials science, nanotechnology, bioengineering, are anticipated achieve higher sensitivity enhanced functional integration, thereby facilitating monitoring, innovative Overall, possess scientific significance value both related diseases, signaling a new era personalized precision medicine.

Язык: Английский

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An indole-fused quinacridone-based fluorescent probe with high photostability and specificity for cellular lipid droplets

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112835 - 112835

Опубликована: Апрель 1, 2025

Язык: Английский

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