Authorea (Authorea),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 17, 2023
DNA
logic
programming,
based
on
the
principles
of
base
complementarity
and
Boolean
operations,
exhibits
organizational
structures
computational
rules
similar
to
machine
language.
Consequently,
programming
enables
decision-making,
output
capabilities
consistent
with
language
in
real-world
applications.
In
recent
years,
thinking
behind
has
synergized
life
sciences,
medicine,
various
interdisciplinary
fields,
establishing
an
intelligent
digitized
research
framework.
It
paved
way
for
cutting-edge
facilitated
transition
from
concept
construction.
This
article
provides
overview
achievements
field
biomedical
applications,
focusing
design
implementation
further
exploring
its
advantages
challenges
frontier
areas.
Molecules,
Год журнала:
2023,
Номер
28(8), С. 3561 - 3561
Опубликована: Апрель 18, 2023
Raman
nanoparticle
probes
are
a
potent
class
of
optical
labels
for
the
interrogation
pathological
and
physiological
processes
in
cells,
bioassays,
tissues.
Herein,
we
review
recent
advancements
fluorescent
imaging
using
oligodeoxyribonucleotide
(ODN)-based
nanoparticles
nanostructures,
which
show
promise
as
effective
tools
live-cell
analysis.
These
nanodevices
can
be
used
to
investigate
vast
number
biological
occurring
at
various
levels,
starting
from
those
involving
organelles,
tissues,
whole
living
organisms.
ODN-based
have
contributed
achievement
significant
comprehension
role
played
by
specific
analytes
inaugurated
new
possibilities
diagnosing
health
conditions.
The
technological
implications
that
emerged
studies
herein
described
could
open
avenues
innovative
diagnostics
aimed
identifying
socially
relevant
diseases
like
cancer
through
utilization
intracellular
markers
and/or
guide
surgical
procedures
based
on
or
imaging.
Particularly
complex
probe
structures
been
developed
within
past
five
years,
creating
versatile
toolbox
analysis,
with
each
tool
possessing
its
own
strengths
limitations
studies.
Analyzing
literature
reports
field,
predict
development
will
continue
near
future,
disclosing
novel
ideas
their
application
therapeutic
diagnostic
strategies.
Biosensors,
Год журнала:
2023,
Номер
13(8), С. 774 - 774
Опубликована: Июль 31, 2023
Recent
advances
in
molecular
technologies
have
provided
various
assay
strategies
for
monitoring
biomarkers,
such
as
miRNAs
early
detection
of
diseases
and
cancers.
However,
there
is
still
an
urgent
unmet
need
to
develop
practical
accurate
miRNA
analytical
tools
that
could
facilitate
the
incorporation
biomarkers
into
clinical
practice
management.
In
this
study,
we
demonstrate
feasibility
using
a
cascade
amplification
method,
referred
“Cascade
Amplification
by
Recycling
Trigger
Probe”
(CARTP)
strategy,
improve
sensitivity
inverse
Molecular
Sentinel
(iMS)
nanobiosensor.
The
iMS
nanobiosensor
developed
our
laboratory
unique
homogeneous
multiplex
bioassay
technique
based
on
surface-enhanced
Raman
scattering
(SERS)
detection,
was
used
successfully
detect
from
samples.
CARTP
strategy
toehold-mediated
strand
displacement
reaction
triggered
linear
DNA
strand,
called
“Recycling
(RTP)
amplify
SERS
signal.
Herein,
show
significantly
improved
with
limit
(LOD)
45
fM,
which
100-fold
more
sensitive
than
non-amplified
previous
report.
We
envision
further
development
optimization
ultimately
will
allow
multiplexed
ultra-high
translation
application.
Physical Chemistry Chemical Physics,
Год журнала:
2022,
Номер
24(39), С. 23959 - 23979
Опубликована: Янв. 1, 2022
In
this
perspective,
recent
advances
in
DNA-mediated
dynamic
plasmonic
nanostructures,
including
assembly
approaches,
actuation
media,
optical
properties
and
bio-applications
are
reviewed,
the
remaining
challenges
perspectives
discussed.
Authorea (Authorea),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 17, 2023
DNA
logic
programming,
based
on
the
principles
of
base
complementarity
and
Boolean
operations,
exhibits
organizational
structures
computational
rules
similar
to
machine
language.
Consequently,
programming
enables
decision-making,
output
capabilities
consistent
with
language
in
real-world
applications.
In
recent
years,
thinking
behind
has
synergized
life
sciences,
medicine,
various
interdisciplinary
fields,
establishing
an
intelligent
digitized
research
framework.
It
paved
way
for
cutting-edge
facilitated
transition
from
concept
construction.
This
article
provides
overview
achievements
field
biomedical
applications,
focusing
design
implementation
further
exploring
its
advantages
challenges
frontier
areas.
