ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
The
rapid
increase
in
the
number
of
stimuli-responsive
polymers,
also
known
as
smart
has
significantly
advanced
their
applications
various
fields.
These
polymers
can
respond
to
multiple
stimuli,
such
temperature,
pH,
solvent,
ionic
strength,
light,
and
electrical
magnetic
fields,
making
them
highly
valuable
both
academic
industrial
sectors.
Recent
studies
have
focused
on
developing
hydrogels
with
self-healing
properties
that
autonomously
recover
structural
integrity
mechanical
after
damage.
hydrogels,
formed
through
dynamic
covalent
reactions,
exhibit
superior
biocompatibility,
responsiveness
particularly
pH
changes.
However,
conventional
are
limited
by
weak
brittle
nature.
To
address
this,
ionizable
moieties
within
polyelectrolytes
be
tuned
create
ionically
cross-linked
leveraging
natural
alginate,
chitosan,
hyaluronic
acid,
cellulose.
integration
liquids
into
these
enhances
conductivity,
positioning
significant
agents.
This
review
focuses
emerging
field
ionic-based
explores
potential
dermal
tissue
engineering.
Advanced Functional Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 31, 2023
Abstract
Ionogels,
composed
of
ionic
liquids
and
supporting
networks,
possess
a
plethora
exceptional
properties,
including
nonvolatility,
remarkable
thermal
electrochemical
stability,
elevated
mechanical
strength,
as
well
outstanding
conductivity.
Based
on
these
extraordinary
characteristics,
ionogels
have
found
extensive
applications
in
diverse
fields
encompassing
functional
materials,
sensors,
soft
electronics,
solid
electrolytes,
biomedicine.
In
recent
years,
witnessed
significant
advancements
emerged
highly
popular
subject
matter.
Consequently,
this
review
provides
comprehensive
overview
the
latest
progress
made
realm
ionogels.
The
preparation
methods
are
initially
introduced
following
concise
introduction.
Subsequently,
properties
ionogels,
high
low
temperature
resistance,
conductivity,
stimuli‐response
self‐healing
recyclability
their
structure‐property
relationships,
comprehensively
discussed.
Moreover,
utilization
skins,
adhesions
other
domains
also
elaborated
upon
extensively.
Finally,
after
succinct
summary,
challenges
prospects
regarding
future
development
thoroughly
deliberated.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Май 31, 2024
Abstract
The
rapid
development
of
the
Internet
Things
and
artificial
intelligence
technologies
has
increased
need
for
wearable,
portable,
self-powered
flexible
sensing
devices.
Triboelectric
nanogenerators
(TENGs)
based
on
gel
materials
(with
excellent
conductivity,
mechanical
tunability,
environmental
adaptability,
biocompatibility)
are
considered
an
advanced
approach
developing
a
new
generation
sensors.
This
review
comprehensively
summarizes
recent
advances
in
gel-based
TENGs
sensors,
covering
their
principles,
properties,
applications.
Based
requirements
working
mechanism
characteristic
advantages
gels
introduced.
Design
strategies
performance
optimization
hydrogel-,
organogel-,
aerogel-based
systematically
summarized.
In
addition,
applications
human
motion
sensing,
tactile
health
monitoring,
human–machine
interaction,
other
related
fields
Finally,
challenges
discussed,
feasible
proposed
to
guide
future
research.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 16, 2024
Topical
drug
delivery
is
widely
used
in
various
diseases
because
of
the
advantages
not
passing
through
gastrointestinal
tract,
avoiding
irritation
and
hepatic
first-pass
effect,
reaching
lesion
directly
to
reduce
unnecessary
adverse
reactions.
The
skin
helps
organism
defend
itself
against
a
huge
majority
external
aggressions
one
most
important
lines
defense
body.
However,
skin’s
strong
barrier
ability
also
obstacle
effectiveness
topical
medications.
Allowing
bioactive,
composition
pass
stratum
corneum
as
needed
reach
target
site
essential
need
for
exert
its
therapeutic
effect.
state
barrier,
choice
system
composition,
individualized
disease
detection
dosing
planning
influence
Nowadays,
enhancing
transdermal
absorption
topically
applied
drugs
hottest
research
area.
first
improve
all
drugs.
Excessive
enhances
accumulation
at
non-target
sites
occurrence
This
paper
introduces
strategies
from
three
perspectives:
delivery,
describes
current
status
shortcomings
research,
provides
new
directions
ideas
research.
Advanced Materials,
Год журнала:
2024,
Номер
36(25)
Опубликована: Март 14, 2024
Multifunctional
flexible
electronics
present
tremendous
opportunities
in
the
rapidly
evolving
digital
age.
One
potential
avenue
to
realize
this
goal
is
integration
of
polyoxometalates
(POMs)
and
ionic
liquid-based
gels
(ILGs),
but
challenge
macrophase
separation
due
poor
compatibility,
especially
caused
by
repulsion
between
like-charged
units,
poses
a
significant
hurdle.
Herein,
possibilities
producing
diverse
homogenous
POMs-containing
ionohydrogels
nanoconfining
POMs
liquids
(ILs)
within
an
elastomer-like
polyzwitterionic
hydrogel
using
simple
one-step
random
copolymerization
method,
are
expanded
vastly.
The
incorporation
polyzwitterions
provides
nanoconfined
microenvironment
effectively
modulates
excessive
electrostatic
interactions
POMs/ILs/H
Advances in Colloid and Interface Science,
Год журнала:
2024,
Номер
331, С. 103244 - 103244
Опубликована: Июнь 26, 2024
Ionic
liquids
(ILs)
play
a
crucial
role
in
the
design
of
novel
materials.
The
ionic
nature
ILs
provides
numerous
advantages
drug
delivery,
acting
as
green
solvent
or
active
ingredient
to
enhance
solubility,
permeability,
and
binding
efficiency
drugs.
They
could
also
function
structuring
agent
development
nano/micro
particles
for
including
micelles,
vesicles,
gels,
emulsion,
more.
This
review
summarize
IL-based
gel
structures
with
their
advanced
delivery
applications.
first
part
focuses
on
formulation
applications
delivery.
second
offers
comprehensive
overview
recent
gel.
It
aims
offer
new
perspectives
attract
more
attention
open
up
avenues
biomedical
gels.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(2), С. 100900 - 100900
Опубликована: Март 6, 2024
Ionic
liquids
(ILs)
have
been
proven
to
be
an
effective
technology
for
enhancing
drug
transdermal
absorption.
However,
due
the
unique
structural
components
of
ILs,
design
efficient
ILs
and
elucidation
action
mechanisms
remain
explored.
In
this
review,
basic
principles
ideal
delivery
system
(TDDS)
are
discussed
considering
melting
point,
skin
permeability,
toxicity,
which
depend
on
molar
ratios,
types,
functional
groups
ions
inter-ionic
interactions.
Secondly,
contributions
development
TDDS
through
different
roles
described:
as
novel
penetration
enhancers
absorption
drugs;
solvents
improving
solubility
drugs
in
carriers;
active
pharmaceutical
ingredients
(API-ILs)
regulating
solubility,
release,
pharmacokinetic
behaviors
polymers
smart
medical
materials.
Moreover,
diverse
mechanisms,
mainly
including
interactions
among
drugs,
polymers,
components,
summarized.
Finally,
future
challenges
related
discussed,
underlying
quantitative
structure-activity
relationships,
complex
interaction
forces
between
anions,
microenvironment,
long-term
stability,
vivo
safety
issues.
summary,
article
will
promote
based
ILs.
