Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

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Current advances in metal–organic frameworks for cancer nanodynamic therapies

Coordination Chemistry Reviews, Год журнала: 2023, Номер 497, С. 215434 - 215434

Опубликована: Сен. 17, 2023

Язык: Английский

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Defect‐Repaired g‐C₃N₄ Nanosheets: Elevating the Efficacy of Sonodynamic Cancer Therapy Through Enhanced Charge Carrier Migration

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(18)

Опубликована: Фев. 7, 2024

Sonodynamic therapy (SDT) has garnered growing interest owing to its high tissue penetration depth and minimal side effects. However, the lack of efficient sonosensitizers remains primary limiting factor for clinical application this treatment method. Here, defect-repaired graphene phase carbon nitride (g-C

Язык: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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Intervening with nanozymes in aging-related diseases: Strategies for restoring mitochondrial function

Biomaterials Advances, Год журнала: 2025, Номер 169, С. 214193 - 214193

Опубликована: Янв. 18, 2025

Язык: Английский

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Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Advanced Materials, Год журнала: 2023, Номер 36(8)

Опубликована: Сен. 19, 2023

Nanozymes, next-generation enzyme-mimicking nanomaterials, have entered an era of rational design; among them, Co-based nanozymes emerged as captivating players over times. been developed and garnered significant attention the past five years. Their extraordinary properties, including regulatable enzymatic activity, stability, multifunctionality stemming from magnetic photothermal conversion effects, cavitation relaxation efficiency, made a rising star. This review presents first comprehensive profiling in chemistry, biology, environmental sciences. The begins by scrutinizing various synthetic methods employed for nanozyme fabrication, such template sol-gel methods, highlighting their distinctive merits chemical standpoint. Furthermore, detailed exploration wide-ranging applications biosensing biomedical therapeutics, well contributions to monitoring remediation is provided. Notably, drawing inspiration state-of-the-art techniques omics, analysis undertaken, employing analogous statistical methodologies provide valuable guidance. To conclude, outlook on challenges prospects presented, spanning microscopic physicochemical mechanisms macroscopic clinical translational applications.

Язык: Английский

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Nanozyme: a rising star for cancer therapy

Nanoscale, Год журнала: 2023, Номер 15(30), С. 12455 - 12463

Опубликована: Янв. 1, 2023

Tumor therapy by nanozymes.

Язык: Английский

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Overview of nanozymes with phosphatase-like activity

Biosensors and Bioelectronics, Год журнала: 2023, Номер 237, С. 115470 - 115470

Опубликована: Июнь 24, 2023

Язык: Английский

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Ultrasonic-assisted synthesis of TiO2/MWCNT/Pani nanocomposite: Photocatalyst characterization and optimization of efficient variables in the degradation of benzene via RSM-CCD

Powder Technology, Год журнала: 2023, Номер 432, С. 119176 - 119176

Опубликована: Ноя. 19, 2023

Язык: Английский

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Defective S‐TiO_2−x/CeO₂ Heterojunction for Mutual Reinforcing Chemodynamic/Sonocatalytic Antibacterial Therapy and Sonoelectric/Ion‐Activated Bone Regeneration

Advanced Functional Materials, Год журнала: 2023, Номер 33(41)

Опубликована: Авг. 30, 2023

Abstract Sonocatalysis and chemodynamics have attracted widespread attention in antibacterial therapy. The transfer efficiency of electrons plays an important role sonocatalysis chemodynamics, how to regulate electron achieve mutual‐reinforcement between chemodynamic efficient therapy is a difficult problem. Here, this study develops defective S‐doped TiO 2 CeO heterojunction(S‐TiO 2− x /CeO ）sonosensitizer that can enhance by regulating valence transitions Ce III /Ce IV sonoelectrons, enhancing sonocatalytic creating heterojunctions accelerate the interface electron, thereby achieving mutual reinforcement chemodynamic. It could kill 99.3% S. aureus under ultrasound (US) irradiation . Due presence mixed states , S‐TiO be as oxy‐substrates. 4+ deplete glutathione reacts with H O bacteria produce reactive oxygen species (ROS). These activities combines ROS generated from sonocatalysis, resulting bacterial death. Meanwhile, electrical signal US stimulation cerium ions activate Wnt/β‐catenin signaling pathway induce hBMSCs differentiate into osteoblast. successfully treats osteomyelitis effectively clearing infection, suppressing inflammatory, promoting bone regeneration, it provides effective treatment for patients deep infection.

Язык: Английский

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