The Journal of Physical Chemistry C,
Год журнала:
2023,
Номер
127(42), С. 20919 - 20928
Опубликована: Окт. 16, 2023
In
this
study,
metal
halide
perovskites,
which
are
excellent
materials
for
optoelectronic
devices,
were
examined
to
construct
molecular
logic
gates.
The
photoluminescence
(PL)
and
electrochemiluminescence
(ECL)
properties
of
the
CsPbBr3
nanocrystals
(NCs)
effectively
maintained
in
CsPbBr3@SiO2
NC
films;
these
films
simply
prepared
by
depositing
on
electrode
surface
through
viscosity
SiO2
coating.
dual-optical
signals
found
have
different
responses
external
stimuli
Fe(III)
dopamine
(DA).
PL
signal
was
quenched
Fe(III),
effect
exacerbated
at
a
high
concentration
DA
due
formation
oxidation
products.
However,
addition
ascorbic
acid
(AA)
could
restore
signal.
While
ECL
did
not
show
evident
changes
with
low
be
reverted
Fe(III).
Thus,
multiple
input–output
circuit
based
film
system
constructed
using
DA,
AA
as
3
inputs
states
6
outputs.
A
series
circuits,
including
an
encoder/decoder,
dual
transfer
gate,
parity
checker,
demultiplexer,
resettable
keypad
lock,
successfully
simulated.
Specifically,
ternary
CONSENSUS
gate
output
initially
mimicked
electrode.
This
work
provide
simple
approach
design
information
modulated
multioptical
perovskites
further
expand
potential
applications
multiple-molecule
recognition,
chemical
storage,
devices.
Analytical Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
The
CRISPR/Cas
technology
shows
great
potential
in
molecular
detection
and
diagnostics.
However,
it
is
still
challenging
to
detect
multiple
targets
simultaneously
using
the
CRISPR-Cas
system.
Herein,
we
ingeniously
leverage
synergistic
effect
of
two
short
single-stranded
DNA
activators
construct
a
CRISPR/Cas12a-driven
electrochemical
sensing
platform
based
on
an
AND
logic
circuit
("AND"
LC-CRISPR)
for
simultaneous
dual
miRNAs.
Specifically,
exponential
amplification
reaction
products
triggered
by
dual-specific
miRNAs
are
designed
as
binary
inputs
bind
with
Cas12a/crRNA,
forming
activating
trans-cleavage
ability
CRISPR-Cas12a
Subsequently,
hairpin
probe
biogate
surface
functionalized
signal
(MB@HP-Fe-MOF)
cleaved
activated
Cas12a,
leading
release
encapsulated
electroactive
molecule
methylene
blue,
thereby
generating
strong
signal.
As
result,
this
"AND"
LC-CRISPR
platform,
requiring
only
single
crRNA
assembled
achieves
miRNA-155
miRNA-21
at
concentrations
low
3.2
fM.
Moreover,
allows
easy
adjustment
according
different
targets,
allowing
be
easily
expanded
analysis
diagnosis
other
multibiomarkers.
This
approach
demonstrates
promising
future
applications
intelligent
diagnostic
medicine.
Nanoscale,
Год журнала:
2023,
Номер
15(43), С. 17386 - 17397
Опубликована: Янв. 1, 2023
A
series
of
logic
operations
with
contrary
functions
was
designed,
besides
the
use
XOR
in
a
pG
and
pC
at
start
end
binary
transmission,
to
detect
errors
biocomputing
an
improvement
DNA
platform
for
intelligent
computing
devices
achieved.
The Journal of Physical Chemistry C,
Год журнала:
2023,
Номер
127(42), С. 20919 - 20928
Опубликована: Окт. 16, 2023
In
this
study,
metal
halide
perovskites,
which
are
excellent
materials
for
optoelectronic
devices,
were
examined
to
construct
molecular
logic
gates.
The
photoluminescence
(PL)
and
electrochemiluminescence
(ECL)
properties
of
the
CsPbBr3
nanocrystals
(NCs)
effectively
maintained
in
CsPbBr3@SiO2
NC
films;
these
films
simply
prepared
by
depositing
on
electrode
surface
through
viscosity
SiO2
coating.
dual-optical
signals
found
have
different
responses
external
stimuli
Fe(III)
dopamine
(DA).
PL
signal
was
quenched
Fe(III),
effect
exacerbated
at
a
high
concentration
DA
due
formation
oxidation
products.
However,
addition
ascorbic
acid
(AA)
could
restore
signal.
While
ECL
did
not
show
evident
changes
with
low
be
reverted
Fe(III).
Thus,
multiple
input–output
circuit
based
film
system
constructed
using
DA,
AA
as
3
inputs
states
6
outputs.
A
series
circuits,
including
an
encoder/decoder,
dual
transfer
gate,
parity
checker,
demultiplexer,
resettable
keypad
lock,
successfully
simulated.
Specifically,
ternary
CONSENSUS
gate
output
initially
mimicked
electrode.
This
work
provide
simple
approach
design
information
modulated
multioptical
perovskites
further
expand
potential
applications
multiple-molecule
recognition,
chemical
storage,
devices.
