Biomimetic copper-doped polypyrrole nanoparticles induce glutamine metabolism inhibition to enhance breast cancer cuproptosis and immunotherapy

Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 204 - 215

Опубликована: Май 31, 2024

Язык: Английский

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Biomimetic Single‐Atom Nanozyme for Dual Starvation‐Enhanced Breast Cancer Immunotherapy

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Abstract Cold exposure (CE) therapy is an innovative and cost‐efficient cancer treatment that activates brown adipose tissue to compete for glucose uptake, leading metabolic starvation in tumors. Exploring the combined antitumor mechanisms of CE traditional therapies (such as nanocatalysis) exciting promising. In this study, a platelet membrane biomimetic single‐atom nanozyme (SAEs) nanodrug (PFB) carrying bis‐2‐(5–phenylacetamido‐1, 2, 4‐thiadiazol‐2‐yl) ethyl sulfide (BPTES) developed use therapy. Owing modification, PFB can effectively target Upon entering cells, dual effect induced by BPTES significantly diminish intracellular ATP levels, resulting substantial reduction cellular (glutathione) GSH, which enhance cytotoxic efficacy reactive oxygen species generated SAEs. This strategy not only boosts ROS production tumors, but also strengthens immune responses, particularly increasing memory T‐cell abundance suppressing distant tumor growth metastasis. Compared with SAEs alone, approach offers superior benefits immunotherapy. study achieves combination nanomedicines first time, providing new ideas future nanomedicine modalities.

Язык: Английский

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A new era of cancer phototherapy: mechanisms and applications

Chemical Society Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The past decades have witnessed great strides in phototherapy as an experimental option or regulation-approved treatment numerous cancer indications.

Язык: Английский

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Multifunctional Pd Single-Atom Nanozyme for Enhanced Cascade Chemodynamic Therapy of Chronic Wounds

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(3), С. 3445 - 3457

Опубликована: Янв. 26, 2024

Nanozymes are considered promising therapeutic agents for infected chronic wounds due to their enzyme-like activity-mediated chemodynamic therapy (CDT). However, they still suffer from low catalytic efficiency and incapacity address excessive glucose heightened inflammatory responses in wounds. Herein, we bound Pd sites CeO2 nanosheets atomically dispersed form by high-temperature calcination, followed loading oxidase (GOx) obtain Pd–CeO2@GOx single-atom nanozymes (SANZs) enhanced cascade CDT of Specifically, highly endogenous first activates the activity GOx situ self-supplement H2O2 protons. Then, an acidic microenvironment, single atoms exert efficient glutathione peroxidase (GSH-Px) mimicking amplify (POD)-mimicking activity, generating burst •OH eradicate Gram-negative Escherichia coli Gram-positive Staphylococcus aureus pathogens suppress biofilm formation. Finally, promote catalase (CAT)-mimicking carriers convert remaining O2, which relieves contributes blood vessel reconstruction This strategy SANZs could accelerate healing within 17 days. Therefore, this study opens up insights into rational design multienzyme active

Язык: Английский

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Recent Advances in the Bioactive Structure and Application of Single-atom Nanozymes

Nano Biomedicine and Engineering, Год журнала: 2023, Номер 16(1), С. 1 - 27

Опубликована: Дек. 8, 2023

Single-atom nanozymes have attracted much attention as a new type of high-performance nanozymes. Compared with other nanozymes, single-atom become the most promising candidates for naturally-occurring enzymes due to their lower cost, better activity, more flexible preparation, higher atom utilization, and compositional structural modifications. Moreover, catalytic activity can be precisely constructed by regulating active center synergistic environment. Advanced characterization techniques combined theoretical calculations accurately identify enzyme-like sites deeply reveal structure-performance correlation. In this review, activities are comprehensively summarized along recent research advances in antitumor, neurological disorders, wound healing, antimicrobial. Finally, we also explore future opportunities challenges design applications.

Язык: Английский

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Colorimetric sensor array for identifying antioxidants based on pyrolysis-free synthesis of Fe–N/C single-atom nanozymes

Talanta, Год журнала: 2024, Номер 279, С. 126621 - 126621

Опубликована: Июль 29, 2024

Язык: Английский

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Mesoporous dual-atom nanozyme induced cuproptosis and apoptosis for boosting immunogenic cell death along with reprogramming tumor immune-suppressive microenvironment

Chemical Engineering Journal, Год журнала: 2025, Номер 506, С. 160294 - 160294

Опубликована: Янв. 1, 2025

Язык: Английский

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An Oxidative Stress Nanoamplifier with Efficient Non-Fenton-Type Hydroxyl Radical Generation and Sulfur Dioxide Release for Synergistic Treatment of Tumor

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Overcoming tumor antioxidant defenses remains a critical challenge for reactive-oxygen-species-mediated therapies. To address this problem, herein, theranostic nanomedicine designated as CCM@MIB has been elaborately constructed. Homologous cancer cell membrane (CCM) camouflage significantly enhances the selective accumulation of at sites. In response to microenvironment (TME), controllably releases Mn ions and sulfur dioxide (SO2) molecules. The released catalyze self-oxidation isoniazid generate highly toxic •OH, while SO2 produced by benzothiazole sulfinate effectively disrupts defense systems. catalase-like activity endowed increased intracellular •O2– level induced further promote •OH production. Therefore, such an intellectual combination non-Fenton-type catalytic therapy gas amplifies oxidative stress efficiently suppresses growth. Additionally, TME-activated magnetic resonance imaging contrast performance is beneficial guiding antitumor treatment. This considerate strategy designed in our work provides ingenious paradigm development efficient

Язык: Английский

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Recent advances in sulfur dioxide releasing nanoplatforms for cancer therapy

Acta Biomaterialia, Год журнала: 2023, Номер 174, С. 91 - 103

Опубликована: Дек. 11, 2023

Язык: Английский

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Glutathione-triggered release of SO₂gas to augment oxidative stress for enhanced chemodynamic and sonodynamic therapy

Biomaterials Science, Год журнала: 2024, Номер 12(9), С. 2341 - 2355

Опубликована: Янв. 1, 2024

Recently, gas therapy has emerged as a promising alternative treatment for deep-seated tumors. However, some challenges regarding insufficient or uncontrolled generation well unclear therapeutic mechanisms restrict its further clinical application. Herein, well-designed nanoreactor based on intracellular glutathione (GSH)-triggered of sulfur dioxide (SO2) to augment oxidative stress been developed synergistic chemodynamic (CDT)/sonodynamic (SDT)/SO2 therapy. The (designed CCM@FH-DNs) is constructed by employing iron-doped hollow mesoporous silica nanoparticles carriers, the surface which was modified with SO2 prodrug 2,4-dinitrobenzenesulfonyl (DNs) and coated cancer cell membranes homologous targeting. CCM@FH-DNs can not only serve Fenton-like agent CDT, but also sonosensitizer SDT. Importantly, release SO2-mediated Both in vitro vivo evaluations demonstrate that performs augmenting therapy-enhanced CDT/SDT via GSH depletion peroxidase-4 enzyme deactivation superoxide dismutase inhibition. Moreover, doped iron ions ensure nanoreactors enable magnetic resonance imaging-guided Such GSH-triggered strategy provides an intelligent paradigm developing efficient tumor microenvironment-responsive treatments.

Язык: Английский

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