Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12049 - 12095

Опубликована: Май 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Язык: Английский

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Oxidative stress–mediated neuroinflammation in Alzheimer’s disease

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 4, 2024

Язык: Английский

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Preparation and Application of Carbon Dots Nanozymes

Antioxidants, Год журнала: 2024, Номер 13(5), С. 535 - 535

Опубликована: Апрель 27, 2024

Carbon dot (CD) nanozymes have enzyme-like activity. Compared with natural enzymes, CD offer several advantages, including simple preparation, easy preservation, good stability and recycling, which has made them a popular research topic in various fields. In recent years, researchers prepared variety of for biosensing detection, medicine tumor therapy, many are based on oxidative stress regulation reactive oxygen species clearance. Particularly to expand their potential applications, elemental doping been utilized enhance the catalytic capabilities other properties nanozymes. This review discusses prevalent techniques synthesis presents diverse applications characteristics. Finally, challenges encountered current utilization presented. The latest progress synthesis, application outlined can help encourage future related researches

Язык: Английский

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N, P, S Codoped Carbon Nanozymes with Enhanced Peroxidase-like Activity and Binding Affinity for Total Antioxidant Capacity Assay

ACS Applied Nano Materials, Год журнала: 2023, Номер 6(24), С. 23303 - 23312

Опубликована: Дек. 5, 2023

Developing peroxidase-like sensors with excellent catalytic activity to construct colorimetric has been an important challenge for a long time. The electronegativity of the doped nonmetallic atoms can change chemical environment carbon material and promote redistribution electrons, thus improving electron transfer channel between nanozyme reaction substrate further enhancing activity. Herein, nitrogen (N), phosphorus (P), sulfur (S) codoped (NPS-C) was successfully designed via one-step high-temperature pyrolysis. Compared N-doped nanozymes (N–C), N P (NP-C) have lower Michaelis–Menten constant, S (NS-C) higher rate. Therefore, based on synergy different atoms, NPS-C exhibited stronger binding affinity, which effectively activated H2O2 produce reactive oxygen intermediates oxidation capacity superoxide anion radical (•O2–) promoted TMB lose be oxidized oxTMB. Moreover, ascorbic acid (AA), as antioxidant model, rapidly consume species reduce linear relationship concentration AA inhibition degree activity, sensor constructed analyze total (TAC) in beverages.

Язык: Английский

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Mobile phone-assisted imprinted nanozyme for bicolor colorimetric visual detection of erythromycin in river water and milk samples

Food Chemistry, Год журнала: 2024, Номер 449, С. 139291 - 139291

Опубликована: Апрель 9, 2024

Язык: Английский

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Ligand density-optimized peroxidase-like activity of gold nanoclusters for colorimetric sensing of biothiols and acetylcholinesterase

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 417, С. 136069 - 136069

Опубликована: Июнь 4, 2024

Язык: Английский

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Photothermal amplified multizyme activity for synergistic photothermal-catalytic tumor therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 679, С. 375 - 383

Опубликована: Сен. 28, 2024

Язык: Английский

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Fluorescent Iron-Doped Polymer Dot Nanozyme-Based Cascade System for Dual-Mode Detection of Acetylcholinesterase Activity and Its Inhibitors

Analytical Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

The advancement of acetylcholinesterase (AChE) activity and its inhibitor assays is crucial for clinical diagnosis, drug screening, environmental monitoring. A nanozyme-mediated cascade reaction system could offer promising prospects a wide range applications in such biosensing; however, the creation nanozyme catalysts with diverse functionalities remains significant challenge. Herein, we have proposed multifunctional iron-doped polymer dots (Fe-PDs) possessing excellent fluorescence peroxidase (POD)-mimicking activity. Notably, Fe-PDs capable catalyzing H

Язык: Английский

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A highly effective peroxidase-mimic nanozyme of S, N-carbon dot-decorated cerium organic framework-based colorimetric detection of Hg²⁺ ion and thiophanate methyl

Analytical Methods, Год журнала: 2024, Номер 16(22), С. 3562 - 3576

Опубликована: Янв. 1, 2024

In this study, we proposed a colorimetric probe as S, N-carbon dot-decorated Ce-MOF (S, N-CD@Ce-MOF) for the dual detection of mercury and thiophanate methyl (TM), which are simultaneously present pollutants in environment foodstuffs. These cause serious threats to human health, such carcinogenicity neurovirulence. Herein, synthesized N-CD@Ce-MOF using hydrothermal method applied it "turn-off-on" detect TM water food samples. shows excellent peroxidase activity by catalyzing chromogenic substrate 3,3',5,5'-tetramethylbenzidine (TMB), resulting deep blue-colored oxidized TMB product (ox TMB) presence H

Язык: Английский

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An Injectable Chitosan-based Hydrogel Incorporating Carbon Dots with Dual Enzyme-Mimic Activities for Synergistically Treatment of Bacteria Infected Wounds

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 241, С. 114006 - 114006

Опубликована: Май 29, 2024

Язык: Английский

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