Nanomedicines for Dry Eye Syndrome: Targeting Oxidative Stress with Modern Nanomaterial Strategies

Molecules, Год журнала: 2024, Номер 29(16), С. 3732 - 3732

Опубликована: Авг. 7, 2024

Dry eye syndrome (DES) is a dynamic, chronic disease of the ocular surface and appendages caused by inflammation. The most common symptoms include redness, itching, blurred vision, resulting from dysfunction meibomian glands impaired tear-film production. Factors contributing to development DES environmental elements, such as UV radiation, internal hormonal imbalances. These factors increase oxidative stress, which exacerbates inflammation on accelerates DES. In recent years, incidence has risen, leading greater need develop effective treatments. Current treatments for dry are limited primarily focus alleviating individual symptoms, reducing surface. However, it crucial understand pathomechanism tailor treatment address underlying causes achieve best possible therapeutic outcomes. Therefore, in this review, we analyzed impact stress gain better understanding its examined recently developed nanosystems that allow drugs be delivered directly site.

Язык: Английский

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Revolutionizing nanozyme technology with metal-organic frameworks: Classification, catalytic mechanisms, regulation and applications in biotechnology

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156850 - 156850

Опубликована: Окт. 1, 2024

Язык: Английский

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Enhanced mimic peroxidase activity of carbon nanozyme by simultaneous phosphorus, oxygen dual-heteroatom doping and nanosheet structure construction

Separation and Purification Technology, Год журнала: 2023, Номер 330, С. 125312 - 125312

Опубликована: Окт. 27, 2023

Язык: Английский

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Precise visualization and ROS-dependent photodynamic therapy of colorectal cancer with a novel mitochondrial viscosity photosensitive fluorescent probe

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 9, 2023

Abstract Background Colorectal cancer (CRC) is a prominent global with high mortality rates among human beings. Efficient diagnosis and treatment have always been challenge for CRC management. Fluorescence guided therapy, which combines therapy into one platform, has brought new chance achieving precise theranostics. Among this, photosensitizers, applied in photodynamic (PDT), given the integration of real-time imaging capacity efficacious feasibility, show great potential to serve as remarkable tools. Although much effort put constructing photosensitizers locating destroying cells, it still need develop novel attain specific detection fulfil effective therapy. Methods Probe HTI was rational synthesized CRC. Spectrometric determination carried out first, followed by 1 O 2 generation ability test. Then, displayed distinguishing cells from normal Further, PDT effect photosensitizer studied vitro. Additionally, used BALB/c nude mice model validate its viscosity labelling tumor suppression characteristics. Results We successfully fabricated mitochondrial targeting probe, HTI, together sensitivity, ultralow background interference, excellent capacity. favorably detection, displaying 11-fold fluorescent intensity enhancement solvents 1.57 cp 2043 cp. demonstrated that could distinguish upon difference viscosity. Moreover, qualified producing efficiency supported sparkling signals DCFH after incubation under light irradiation. More importantly, performance CDX determined, enriching multifunctional validation vivo. Conclusions In this study, sensitive response possess Both vitro cell vivo trials proved effectively served robust scaffold labeling clearance. This breakthrough discovery held immense advancing early management through PDT. By leveraging HTI's properties, medical professionals benefit improved diagnostic accuracy targeted management, ultimately leading enhanced patient outcomes.

Язык: Английский

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Dual-mode colorimetric-fluorescence biosensor for endotoxin detection based on CS@Fe,Cu/CDs-MnO2 nanomaterials

Talanta, Год журнала: 2024, Номер 285, С. 127330 - 127330

Опубликована: Дек. 9, 2024

Язык: Английский

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