RSC Advances, Год журнала: 2025, Номер 15(11), С. 8180 - 8188
Опубликована: Янв. 1, 2025
This study aimed to synthesize and characterize silver-based metal–organic frameworks (Ag-MOFs) using 1,4-diazabicyclo[2.2.2]octane (DABCO) as the organic ligand assess their antibacterial cytotoxic properties.
Язык: Английский
Progress in Materials Science, Год журнала: 2024, Номер 148, С. 101387 - 101387
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
11
Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(5), С. 100951 - 100951
Опубликована: Авг. 23, 2024
Metal-organic frameworks (MOFs) offer innovative solutions to the limitations of traditional oral drug delivery systems through their unique combination metal ions and organic ligands. This review systematically examines structural properties principles MOFs, setting stage for application in delivery. It discusses various classes including those based on zirconium, iron, zinc, copper, titanium, aluminum, potassium, magnesium, assessing drug-loading capacities, biocompatibility, controlled release mechanisms. The effectiveness MOFs is illustrated case studies that highlight capabilities enhancing solubility, providing protection against harsh gastrointestinal environment, enabling precise release. addresses potential challenges, particularly toxicity concerns associated with calls further research into biocompatibility interactions biological systems. concludes by emphasizing revolutionizing delivery, highlighting critical need comprehensive harness full clinical applications.
Язык: Английский
Процитировано
10
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
Abstract Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies the absence of curative treatments. Despite advances symptomatic management, early diagnosis remains essential for mitigating progression improving patient outcomes. Traditional diagnostic methods, such as MRI, PET, cerebrospinal fluid biomarker analysis, are often inadequate detection these diseases. Emerging porous materials, including metal–organic frameworks (MOFs), covalent–organic (COFs), MXene, zeolites, silicon, offer promising new approaches neurodegenerative These characterized by highly tunable physicochemical properties, have potential capture concentrate disease‐specific biomarkers amyloid‐beta (Aβ), tau protein, alpha‐synuclein (α‐Syn). The integration materials into advanced biosensors real‐time holds promise revolutionizing neurodiagnostic, enabling non‐invasive, sensitive, specific platforms. Furthermore, incorporation artificial intelligence (AI) machine learning (ML) techniques analysis sensor data enhances accuracy allows more efficient interpretation profiles. AI ML can optimize feature selection, improve pattern recognition, facilitate prediction progression, making them indispensable tools personalized medicine. This review explores diagnostics, emphasizing design, functionality, synergistic role advancing clinical applications.
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
Inhalation delivery, offering a direct pathway for administering drugs to the lungs in form of dry powders or aerosols, stands out as an optimal approach localized treatment pulmonary diseases. However, intricate anatomical architecture lung often poses challenges maintaining effective drug concentrations within over extended periods. This highlights pressing need develop rational inhalable delivery systems that can improve outcomes respiratory Metal-organic frameworks (MOFs) assembled from inorganic metal ions and organic ligands, characterized by customizable porous chemical composition, modifiable porosity, vast surface area, straightforward modification, adjustable biocompatibility, have garnered extensive attention biomedical sphere. The introduction MOFs into inhalation therapy represents promising avenue navigate past hurdles associated with traditional methods. Therefore, this review summarizes characteristics together latest advances, challenges, opportunities utilizing treating diseases discusses prospects field alongside potential pathways translating strategy clinic.
Язык: Английский
Процитировано
2
RSC Advances, Год журнала: 2025, Номер 15(11), С. 8180 - 8188
Опубликована: Янв. 1, 2025
This study aimed to synthesize and characterize silver-based metal–organic frameworks (Ag-MOFs) using 1,4-diazabicyclo[2.2.2]octane (DABCO) as the organic ligand assess their antibacterial cytotoxic properties.
Язык: Английский
Процитировано
2