Sprayable and self-healing chitosan-based hydrogels for promoting healing of infected wound via anti-bacteria, anti-inflammation and angiogenesis

Carbohydrate Polymers, Год журнала: 2024, Номер 337, С. 122147 - 122147

Опубликована: Апрель 10, 2024

Язык: Английский

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Bacterial cellulose-based hydrogel with regulated rehydration and enhanced antibacterial activity for wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 267, С. 131291 - 131291

Опубликована: Апрель 5, 2024

Язык: Английский

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Co-assembly strategies of natural plant compounds for improving their bioavailability

Food & medicine homology., Год журнала: 2024, Номер 2(2), С. 9420022 - 9420022

Опубликована: Июль 18, 2024

Язык: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101553 - 101553

Опубликована: Фев. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Язык: Английский

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NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication

Journal of Biological Engineering, Год журнала: 2025, Номер 19(1)

Опубликована: Фев. 5, 2025

The rise of antibiotic resistance has made bacterial infections a persistent global health issue. In particular, extracellular polymeric substances (EPS) secreted by bacteria limit the effectiveness conventional antibiotics, making biofilm removal challenging. To address this, we created ND@PDA nanoparticles coating surface nanodiamonds (ND) with polydopamine (PDA). These were then integrated into polyvinyl alcohol to fabricate PVA/ND@PDA nanofiber scaffolds, resulting in an innovative platform enhanced photothermal, antibacterial and antibiofilm properties. Upon exposure near-infrared (NIR) light, scaffolds exhibited significant photothermal activity, oxidative stress effectively damaging key components, such as biofilm, membranes, proteins. Additionally, catechol groups PDA provided strong cell adhesion high biocompatibility on surface. Our research proposes that not only addresses antibiotic-resistant but also contributes advancements wound healing therapies enabling controlled action minimal toxicity.

Язык: Английский

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The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 229 - 229

Опубликована: Фев. 5, 2024

This review is concerned with chronic wounds, an emphasis on biofilm and its complicated management process. The basics of antimicrobial photodynamic therapy (PDT) underlying mechanisms for microbial eradication are presented. Intrinsically active nanocarriers (polydopamine NPs, chitosan polymeric micelles) that can further potentiate the effect discussed. also delves into role photoactive electrospun nanofibers, either in their eluting or non-eluting mode action, accelerating healing wounds. Synergic strategies to augment PDT-mediated nanofibers reviewed.

Язык: Английский

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A smart dual-responsive nanoplatform for delivery of prochloraz for the control of rice blast disease

Advanced Agrochem, Год журнала: 2024, Номер 3(4), С. 328 - 336

Опубликована: Фев. 5, 2024

Nano-controlled release formulations present a promising strategy to mitigate pesticide losses and enhance efficiency. In this study, pH GSH-responsive nanoplatform using mesoporous organosilica nanoparticles (MONs) as carrier poly(tannic acid) (PTA) capping agent was established for controlling prochloraz (Pro) release. The obtained Pro@MON@PTA characterized by transmission electron microscopy (TEM), scanning (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA). results indicate the successful preparation of nanoparticles, featuring uniform particle size (190 nm), excellent dispersibility, loading efficiency 17.2%. Evaluation contact angle adhesion work demonstrated superior MON@PTA rice leaves compared MON. Controlled studies revealed dual-responsive properties acid GSH. Additionally, photostability testing indicated effective ultraviolet light shielding carrier, reducing degradation under irradiation. Bioassay equivalent fungicidal activity against Magnaporthe oryzae between technical EW after 7-day treatment. However, in vivo experiments that exhibited control efficacy EW. These findings suggested holds significant potential plant disease management.

Язык: Английский

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Nano-fibre matrix loaded with multi-nutrients to achieve balanced crop nutrition in greengram (Vigna radiata L.)

Plant Physiology and Biochemistry, Год журнала: 2024, Номер 207, С. 108369 - 108369

Опубликована: Янв. 17, 2024

Язык: Английский

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Thermal-Responsive Antibacterial Hydrogel with Photothermal Therapy and Improving Wound Microenvironment for Promote Healing

Antioxidants, Год журнала: 2024, Номер 13(7), С. 857 - 857

Опубликована: Июль 17, 2024

Skin damage is one of the most prevalent human injuries, which affects health beings. However, skin often accompanied by bacterial infection and wound microenvironment changes, causing to normal cells inhibiting healing. Herein, we designed a thermal-responsive antibacterial hydrogel (GAG hydrogel) loaded with catalase (CAT)-like Au@Pt@MgSiO3 nanoparticles (APM NPs) gentamicin (GM) promote The GAG was used in photothermal therapy (PTT)/antibiotic combination kill bacteria, reduce use antibiotics, improve microenvironment, cell proliferation, accelerate Under near-infrared laser irradiation, APM NPs generated local hyperthermia bacteria. Meanwhile, heat led change hydrogel’s morphology, enabling it release GM prevent overuse antibiotics. Subsequently, CAT-like ability decreased oxidative stress caused hydrogen peroxide (H2O2), thus remodeling microenvironment. Then, weakly acidic decomposition magnesium ions (Mg2+), promoting growth migration for Therefore, studied (GAG) has potential field

Язык: Английский

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Antibacterial nonwoven materials in medicine and healthcare

Journal of Biomaterials Applications, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Bacterial infection has always been a severe challenge for mankind. The use of antibacterial nonwoven materials provides lot convenience in daily life and clinical practice grammar revision, it become an important solution to avoid bacterial life. This review systematically examines the spin bonding, melt blown, hydroneedling electrospinning methods fabrication materials, summarizes methods. Finally, discusses applications medical protection, external healthcare, circulation care implantable healthcare intelligent protection detection. comprehensive overview aims provide valuable insights advancement domain medicine health care. In future, are expected evolve towards biodegradability, composite functionalization, minimally invasive techniques, diversification, intelligence, thereby holding immense potential healthcare.

Язык: Английский

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