Progress in Organic Coatings, Год журнала: 2024, Номер 192, С. 108466 - 108466
Опубликована: Май 3, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2025, Номер 515, С. 163723 - 163723
Опубликована: Май 13, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101338 - 101338
Опубликована: Ноя. 12, 2024
Elevated levels of oxidative stress, inflammation, and a dysregulated osteoclastogenesis balance frequently characterize the microenvironment osteoporosis, which impedes processes healing repair. Existing treatment approaches are limited in scope rely primarily on factors drugs. An injectable hydrogel designed for ROS-responsive release H2S gas is presented this study. The first network comprises sodium alginate (SA-SATO) chelated with S-aroylthiooxime (SATO) an H2S-generating group, while second composed photocrosslinkable PEGDA. Through integration Cys-releasing microspheres that reactive ROS, composite was developed exhibited advantageous mechanical characteristics biosafety. effectively promoted osteogenic differentiation mesenchymal stem cells, modulated macrophage polarization, decreased inflammatory responses, halted cell apoptosis, as evidenced by vitro experiments. Additionally, it released mitigated excess ROS cells. efficacy promoting bone defect repair regeneration osteoporotic model further validated vivo findings. In summary, exhibits potential viable approach to address defects harmonizing osteogenesis osteoclast activity, modulating injuries, reducing inflammation. Consequently, presents strategy efficient defects.
Язык: Английский
Процитировано
2
Macromolecular Rapid Communications, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 26, 2024
Abstract Osteoporosis induces severe oxidative stress and disrupts bone metabolism, complicating the treatment of defects. Current therapies often have side effects require lengthy regeneration periods. Hydrogels, known for their flexible mechanical properties degradability, are promising carriers drugs bioactive factors in tissue engineering. However, they lack ability to regulate local pathological environment osteoporosis expedite repair. Polyphenols, with antioxidative, anti‐inflammatory, metabolism‐regulating properties, emerged as a solution. Combining hydrogels polyphenols, polyphenol‐based can metabolism while providing support adhesion, promoting osteoporotic regeneration. This review first provides brief overview types polyphenols mechanisms facilitating antioxidant, modulation modulating osteoporosis. Next, this examines recent advances defects, including use angiogenesis, modulation, drug delivery, stem cell therapy. Finally, it highlights latest research on polyphenol defect Overall, aims facilitate clinical application
Язык: Английский
Процитировано
2
Gels, Год журнала: 2024, Номер 10(7), С. 429 - 429
Опубликована: Июнь 28, 2024
Injectable hydrogels show great promise for bone tissue engineering applications due to their high biocompatibility and drug delivery capabilities. The defects in osteoporosis are usually characterized by an oxidative inflammatory microenvironment that impairs the regeneration capability of tissues. To attenuate reactive oxygen species (ROS) promote regeneration, anti-oxidative hydrogel with osteogenic capacity was developed this study. poorly water soluble, natural antioxidant, resveratrol, encapsulated thiolated Pluronic F-127 micelles over 50-times-enhanced solubility. injectable facilely formed because new thioester bond between free thiol group modified arylate hyaluronic acid (HA)–acrylate. resveratrol-loaded showed good viscoelastic properties vitro stability cyto-compatible bone-marrow-derived mesenchymal stem cells (BMSCs). allowed a sustained release resveratrol at least two weeks effectively enhanced differentiation BMSCs up-regulation markers, including ALP, OCN, RUNX-2, COL1. Moreover, exhibited anti-inflammatory abilities through scavenging intracellular ROS RAW264.7 inhibiting gene expression secretion pro-inflammatory cytokines TNF-α IL-1β under LPS exposure. In summary, results suggest our multifunctional loaded bearing osteogenic, anti-oxidative, actions is easily prepared represents promising platform repair osteoporotic defects.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136375 - 136375
Опубликована: Окт. 9, 2024
Язык: Английский
Процитировано
0
Progress in Organic Coatings, Год журнала: 2024, Номер 192, С. 108466 - 108466
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
0