International Journal for Vitamin and Nutrition Research,
Год журнала:
2024,
Номер
95(1)
Опубликована: Дек. 27, 2024
Dry
Eye
Disease
(DED)
significantly
impacts
global
populations,
causing
discomfort
and
vision
problems.
This
review
explores
the
effects
of
lutein
supplementation
on
DED
symptoms
signs.
A
systematic
was
conducted
following
PRISMA
guidelines,
examining
clinical
trials
from
databases
including
PubMed,
Web
Science,
EMBASE,
Cochrane
Library.
Six
randomized
controlled
(RCTs)
involving
584
subjects
were
included.
Meta-analysis
not
due
to
heterogeneity
in
study
designs,
dosages,
outcome
measures.
Lutein
dosages
ranged
3
mg/day
20
mg/day,
with
treatment
durations
4
12
weeks.
Improvements
observed
subjective
symptoms,
significant
reductions
Ocular
Surface
Index
(OSDI)
scores
some
studies.
Objective
measures
also
showed
positive
results:
tear
break-up
time
(TBUT)
increased
trials.
However,
other
studies
reported
no
differences
between
control
groups,
reflecting
outcomes.
Schirmer's
test
corneal-conjunctival
staining
results
varied,
showing
improvements
others
not.
may
benefit
patients
by
improving
film
stability.
heterogeneity,
larger,
well-designed
RCTs
are
needed
establish
standardized
dosing
confirm
these
findings.
Heliyon,
Год журнала:
2024,
Номер
10(4), С. e26009 - e26009
Опубликована: Фев. 1, 2024
Drug-delivery
systems
(DDSs)
are
designed
to
deliver
drugs
their
specific
targets
minimize
toxic
effects
and
improve
susceptibility
clearance
during
targeted
transport.
Peptides
have
high
affinity,
low
immunogenicity,
simple
amino
acid
composition,
adjustable
molecular
size;
therefore,
most
peptides
can
be
coupled
via
linkers
form
peptide-drug
conjugates
(PDCs)
act
as
active
pro-drugs.
PDCs
widely
thought
promising
DDSs,
given
ability
drug
bio-compatibility
physiological
stability.
Peptide-based
DDSs
often
used
therapeutic
substances
such
anti-cancer
nucleic
acid-based
drugs,
which
not
only
slow
the
degradation
rate
of
in
vivo
but
also
ensure
concentration
at
site
prolong
half-life
vivo.This
article
provides
an
profile
advancements
future
development
functional
peptide-based
delivery
both
domestically
internationally
recent
years,
expectation
achieving
incorporating
taking
full
advantage
synergistic
effects.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
Oral
drug
delivery
is
a
promising
approach
for
the
treatment
of
various
gastrointestinal
(GI)
diseases
but
poses
significant
challenges
to
target
non‐GI
diseases.
The
intestinal
barrier
forms
anatomical
challenge
reach
diseased
site,
along
with
physiological
such
as
stability
in
GI
tract.
These
lead
development
targeted
nanoparticles
and
strategies
cross
protect
them
from
harsh
conditions
tract,
improving
absorption
into
circulatory
system,
bioavailability,
ensuring
regulated
release.
Targeting
ligands
chitosan,
Butyrate
(BU),
yeast
capsule
(YC)
shows
effective
permeability
across
epithelium.
After
crossing
epithelium,
these
can
effectively
treat
atherosclerosis,
cancers,
neurodegenerative
diseases,
fibrosis,
post‐traumatic
osteoarthritis.
However,
including
low
bioavailability
still
persist,
which
reduce
efficacy
therapeutics
should
be
considered
designing
potential
therapies
near
future.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(21), С. 27040 - 27054
Опубликована: Май 14, 2024
Strong
precorneal
clearance
mechanisms
including
reflex
blink,
constant
tear
drainage,
and
rapid
mucus
turnover
constitute
great
challenges
for
eye
drops
effective
drug
delivery
to
the
ocular
epithelium.
In
this
study,
cyclosporine
A
(CsA)
treatment
of
dry
disease
(DED)
was
selected
as
model
drug.
Two
strategies,
PEGylation
penetration
cationization
potent
cellular
uptake,
were
combined
construct
a
novel
CsA
nanosuspension
(NS@lipid-PEG/CKC)
by
coating
nanoscale
particles
with
mixture
lipids,
DSPE-PEG2000,
cationic
surfactant,
cetalkonium
chloride
(CKC).
NS@lipid-PEG/CKC
mean
size
∼173
nm
positive
zeta
potential
∼+40
mV
showed
promoted
penetration,
good
cytocompatibility,
more
prolonged
retention
without
obvious
irritation.
More
importantly,
recovered
production
goblet
cell
density
efficiently
than
commercial
nanoemulsion
on
rat
model.
All
results
indicated
that
combination
might
provide
promising
strategy
coordinate
uptake
enhanced
epithelium
nanomedicine-based
drops.
