Опубликована: Ноя. 15, 2024
Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154855 - 154855
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
21
Chemical Engineering Journal, Год журнала: 2024, Номер 489, С. 151200 - 151200
Опубликована: Апрель 10, 2024
Язык: Английский
Процитировано
6
Pharmaceutics, Год журнала: 2024, Номер 16(9), С. 1188 - 1188
Опубликована: Сен. 8, 2024
Skin and soft-tissue infections require significant consideration because of their prolonged treatment duration propensity to rapidly progress, resulting in severe complications. The primary challenge stems from the involvement drug-resistant microorganisms that can form impermeable biofilms, as well possibility infection extending deep into tissues, thereby complicating drug delivery. Dissolving microneedle patches are an innovative transdermal drug-delivery system effectively enhances penetration through stratum corneum barrier, increasing concentration at site infection. They offer highly efficient, safe, patient-friendly alternatives conventional topical formulations. This comprehensive review focuses on recent advances emerging trends dissolving-microneedle technology for antimicrobial skin-infection therapy. Conventional antibiotic microneedles compared with those based agents, such quorum-sensing inhibitors, peptides, antimicrobial-matrix materials. also highlights potential incorporating chemodynamic, nanoenzyme antimicrobial, photodynamic, photothermal antibacterial therapies. explores advantages various therapies emphasizes combined application improve efficacy microneedles. Finally, this analyzes druggability different discusses possible future developments.
Язык: Английский
Процитировано
4
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract Liver ischemia and reperfusion (I/R) injury is a reactive oxygen species (ROS)‐related disease that occurs during liver transplantation resection hinders postoperative function recovery. Current approaches to alleviate I/R have limited effectiveness due the short circulation time, poor solubility, severe side effects of conventional antioxidants anti‐inflammatory drugs. Herein, universal strategy proposed fabricate Trojan horse‐like biohybrid nanozyme (THBN) with hepatic‐targeting capabilities. Tannic acid (TA) mediates adeno‐associated virus (AAV8) decoration onto 2D Ti 3 C 2 nanosheets, resulting in THBN size 116.2 ± 9.5 nm. Remarkably, exhibits catalase (CAT)‐like activity, broad‐spectrum ROS scavenging activity targeted delivery tissue owing presence AAV8. Both vivo vitro experiments confirmed efficacy attenuating by mitigating inflammation oxidative stress inhibiting hepatocellular apoptosis. RNA‐seq analysis suggests may activating PKC pathway. The effective targeting therapeutic capabilities represent an advancement nanotherapeutics for hepatic ischemia‒reperfusion injury, shedding light on promising potential this next‐generation nanotherapeutic approach.
Язык: Английский
Процитировано
0
Biomaterials Research, Год журнала: 2025, Номер 29
Опубликована: Янв. 1, 2025
The process of wound healing is frequently impeded by metabolic imbalances within the microenvironment. MXenes exhibit exceptional biocompatibility, biodegradability, photothermal conversion efficiency, conductivity, and adaptable surface functionalization, demonstrating marked potential in development multifunctional platforms for healing. Moreover, integration with other bioactive nanomaterials has been shown to enhance their therapeutic efficacy, paving way innovative approaches In this review, we provide a systematic exposition mechanisms through which facilitate offer comprehensive analysis current research landscape on MXene-based composites field. By delving into latest scientific discoveries, identify existing challenges future trajectories advancement MXenes. Our evaluation aims insightful guidance formulation more effective strategies.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106688 - 106688
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Journal of Colloid and Interface Science, Год журнала: 2025, Номер 689, С. 137247 - 137247
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2024, Номер 34(48)
Опубликована: Сен. 30, 2024
Abstract Deferred diabetic skin healing is an ever‐growing complication owing to the hyperglycemic microenvironment, which accelerates generation of advanced glycated end products (AGEs) and provides a hotbed for pathogenic infection. Here, H 2 S‐evolving bio‐heterojunction enzyme (BioHJzyme), consisted by MXene/FeS glucose oxidase (GOx) devised. It presents glutathione peroxidase (GPx)‐ (POD)‐mimetic antibacterial activity anti‐pathogens wound regeneration AGEs depression. The GOx catalyzes glucose, resulting in reducing bacterial nutrient supplying O . POD‐mimetic BioHJzyme hydroxyl radical (•OH) with turnover number 4.45 × 10 −1 s , while GPx‐mimetic it consumes further •OH accumulation. can be enhanced near infrared laser (NIR) irradiation efficient separation electron‐hole pairs originated from heterostructure, NIR‐activatable 1 production. Moreover, evolves S acidic environment, acting as donor, protects cells around oxidative damage AGEs, rescues mitochondrial respiration, improves extracellular matrix deposition ameliorates dysfunction fibroblasts through TGF‐β/Smad pathway. work proof‐of‐concept bacteria‐invaded via BioHJzyme.
Язык: Английский
Процитировано
3
Solar Energy Materials and Solar Cells, Год журнала: 2024, Номер 274, С. 112996 - 112996
Опубликована: Июнь 18, 2024
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136604 - 136604
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2