Polymers,
Год журнала:
2024,
Номер
16(24), С. 3516 - 3516
Опубликована: Дек. 18, 2024
Powder-based
hemostatic
materials
have
offered
unprecedented
opportunities
for
the
effective
sealing
and
repair
of
irregularly
shaped
wounds
high-pressure,
noncompressible
arterial
bleeding
caused
by
surgeries,
traffic
accidents,
wartime
injuries.
However,
inadequate
adhesion
to
poor
hemostasis
in
biological
tissues
remains
challenging.
Herein,
we
report
a
self-gelling
powder
based
on
polyacrylic
acid/polyethyleneimine/polyethylene
glycol
(named
PPG)
rapid
antibacterial
ability.
When
deposited
wounds,
PPG
can
absorb
interfacial
liquid
rapidly
swell
into
physically
cross-linked
hydrogel
situ
within
2
s
form
pressure-resistant
physical
barrier.
Furthermore,
vivo
vitro
results
indicate
that,
as
an
sealant,
possesses
ease
use,
excellent
hemocompatibility,
strong
abilities,
superior
blood
clotting
abilities.
The
capability
is
demonstrated
variety
injury
models
rats
rabbits.
All
these
factors
show
with
its
wound
treatment
profound
biomaterial
surgical
applications.
Polymers,
Год журнала:
2024,
Номер
16(13), С. 1795 - 1795
Опубликована: Июнь 25, 2024
A
novel
self-gelatinizing
powder
was
designed
to
accelerate
wound
healing
through
enhanced
hemostasis
and
tissue
recovery.
Significantly,
this
research
addresses
the
critical
need
for
innovative
management
solutions
by
presenting
a
approach.
Carboxymethylcellulose
calcium
(CMC-Ca)
synthesized
using
an
ion
exchange
method,
lysine
(Lys)
integrated
physical
mixing
augment
material’s
functional
characteristics.
The
prepared
underwent
comprehensive
evaluation
its
self-gelling
capacity,
gelation
time,
adhesion,
swelling
rate,
coagulation
efficiency,
hemostatic
effectiveness,
promotion.
Results
indicate
that
exhibited
remarkable
water
absorption
capabilities,
absorbing
liquid
up
30
times
weight
achieving
rapid
within
3
min.
inclusion
of
Lys
notably
powder’s
gel-forming
properties.
time
determined
be
4
s
rotational
rheometer,
with
rapidly
forming
stable
gel
on
skin
surface.
Furthermore,
in
mouse
injury
model,
near-complete
recovery
observed
14
days,
underscoring
impressive
self-healing
attributes
promising
application
prospects
management.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(33), С. 43244 - 43256
Опубликована: Авг. 13, 2024
The
development
of
efficient
hemostatic
materials
is
crucial
for
achieving
rapid
hemorrhage
control
and
effective
wound
healing.
Inorganic
polyphosphate
(polyP)
recognized
as
an
modulator
the
blood
coagulation
process.
However,
specific
effect
polyP
chain
length
on
not
yet
fully
understood.
Furthermore,
calcium
ions
(Ca
Polymers,
Год журнала:
2024,
Номер
16(7), С. 1008 - 1008
Опубликована: Апрель 7, 2024
Natural
polymer-based
adhesive
hydrogels
have
garnered
significant
interest
for
their
outstanding
strength
and
versatile
applications,
in
addition
to
being
eco-friendly.
However,
the
capabilities
of
purely
natural
products
are
suboptimal,
which
hampers
practical
use.
To
address
this,
we
engineered
carboxymethyl
cellulose
(CMC)
surfaces
with
complementary
bases,
adenine
(A)
thymine
(T),
facilitate
self-assembly
(CMC-AT)
a
nanofiber
configuration.
Impressively,
shear
reached
up
6.49
MPa
mere
2%
concentration.
Building
upon
this
innovation,
conducted
comparative
analysis
adhesion
properties
between
CMC
CMC-AT
hydrogel
adhesives
when
applied
delignified
non-delignified
wood
chips.
We
examined
interplay
substrate,
as
well
role
mechanical
interlocking
overall
performance.
Our
findings
offer
fresh
perspective
on
development
new
biodegradable
polymer
adhesives.
