Journal of drug targeting, Год журнала: 2024, Номер unknown, С. 1 - 14
Опубликована: Июнь 4, 2024
The use of reactive oxygen species (ROS) to target cancer cells has become a hot topic in tumor therapy.
Язык: Английский
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis usually asynchronous due to opposite effect transport them. Herein, systematic glucose deprivation, by inhibiting upstream uptake promoting downstream consumption, is proposed synchronously evoke ferroptosis. As an example, Au nanodots Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) employed regulate SLC7A11/GSH/GPX4 axis performing disulfidptosis- ferroptosis-mediated therapy synchronously. In this scenario, exhibit oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit downregulating 1, depriving fundamentally. The systematical deprivation limits supplement NADPH suppresses axis, thus solving contradiction addition, efficient delivery exogenous iron ions FeOOH@Fe-Ap@Au NSs self-supplied H2O2 through nanodots-catalytic oxidation facilitate Fenton reaction therewith help amplify a result synchronous occurrence ferroptosis, good efficacy in ovarian cancer therapeutic model.
Язык: Английский
Процитировано
1
Carbohydrate Polymers, Год журнала: 2024, Номер 343, С. 122489 - 122489
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
5
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 105998 - 105998
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
5
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155048 - 155048
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
3
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113953 - 113953
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101852 - 101852
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153366 - 153366
Опубликована: Июнь 20, 2024
Язык: Английский
Процитировано
2