Engineered microbial living matter for diagnostics, prevention, and therapy

Current Opinion in Biotechnology, Год журнала: 2025, Номер 92, С. 103269 - 103269

Опубликована: Фев. 6, 2025

Язык: Английский

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Bacterial-Mediated In Situ Engineering of Tumour-Associated Macrophages for Cancer Immunotherapy

Cancers, Год журнала: 2025, Номер 17(5), С. 723 - 723

Опубликована: Фев. 20, 2025

Background/Objectives: Tumour-associated macrophages (TAMs) are critical components of the tumour microenvironment (TME), significantly influencing cancer progression and treatment resistance. This review aims to explore innovative use engineered bacteria reprogram TAMs, enhancing their anti-tumour functions improving therapeutic outcomes. Methods: We conducted a systematic following predefined protocol. Multiple databases were searched identify relevant studies on phenotypic plasticity, for reprogramming. Inclusion exclusion criteria applied select studies, data extracted using standardised forms. Data synthesis was performed summarise findings, focusing mechanisms benefits non-pathogenic modify TAMs. Results: The summarises findings that can selectively target promoting shift from tumour-promoting M2 phenotype tumour-fighting M1 phenotype. reprogramming enhances pro-inflammatory responses activity within TME. Evidence various indicates significant regression improved immune bacterial therapy. Conclusions: Reprogramming TAMs presents promising strategy approach leverages natural targeting abilities directly tumour, potentially patient outcomes offering new insights into immune-based treatments. Further research is needed optimise these methods assess clinical applicability.

Язык: Английский

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Preclinical Assessment of Living Therapeutic Materials: State-of-Art and Challenges

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Living Therapeutic Materials represent a promising technology to tackle therapeutic problems that classical materials cannot address. Despite the advancements on new functions of these devices, applications, and fabrication methods, preclinical evaluation is still very limited challenges appear when incorporating living devices in contact with host. This critical bottleneck path translation clinic. Therefore, we have compiled literature Materials, focus microorganism-based materials, summarized investigations carried out assess their biocompatibility, safety, efficacy. We split three parts: vitro, ex vivo, vivo assessments, where describe common practices remaining challenges.

Язык: Английский

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Prussian blue nanoparticle-based pH-responsive self-assembly for enhanced photothermal and chemotherapy of tumors

Journal of Photochemistry and Photobiology B Biology, Год журнала: 2024, Номер 256, С. 112938 - 112938

Опубликована: Май 10, 2024

Язык: Английский

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Injectable microgels containing genetically engineered bacteria for colon cancer therapy through programmed Chemokine expression

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101337 - 101337

Опубликована: Ноя. 13, 2024

Язык: Английский

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