Near-infrared electrochemiluminescence/smart visual dual-channel sensor based on magnetic derivative and microchip of terbium-based double-ligand MOG for detecting nitrofurazone and Cr(VI)

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159385 - 159385

Опубликована: Янв. 1, 2025

Язык: Английский

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A molecularly imprinted near-infrared electrochemiluminescence sensor based on copper nanowires and signal dual-amplification strategy for sensitive enrofloxacin detection

Food Chemistry, Год журнала: 2025, Номер 476, С. 143414 - 143414

Опубликована: Фев. 14, 2025

Язык: Английский

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Electrochemiluminescence Biosensor Based on a Self-protected DNAzyme Walker with a Circular Bulging DNA Shield for MicroRNA Detection

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Herein, an electrochemiluminescence (ECL) biosensor is established for the ultrasensitive detection of microRNA (miRNA) by integrating a self-protected DNAzyme walker machine on Au nanoparticle–modified electrode. Using Let-7a miRNA as model target and introducing target-binding domain into middle catalytic core, core separated that can inhibit cleavage activity serve arch-like protective shield, resulting in walker. High-efficiency hybridization between activates machine, enabling high its substrate without requiring additional energy input. Importantly, each step results strand liberation Ru(bpy)2(mcpbpy)2+ (Ru)-labeled DNA fragment, considerably reducing ECL signal Ru. Under optimized experimental conditions, limit 51.4 aM within wide linear range 100 aM–100 pM. This proposed strategy bold innovation rapid sensitive low-abundance biomarkers, offering promising application early cancer diagnosis relevant research.

Язык: Английский

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Homogeneous Multicycle Cascaded DNA Circuit for Sensitive “Signal On-Off-Super On” PEC Biosensing

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

The minor changes of miRNA levels due to various diseases and cancers bring great challenges for early diagnosis. Here we propose a "signal on-off-super on" PEC biosensor based on homogeneous multicycle cascaded DNA circuit SnSe/CdS photoanode sensitive detection biomarker miRNA-222. Specifically, Z-type heterojunction with greatly enhanced photoanodic performance was developed provide the initial "on" signal. target miRNA-222 converted dendritic structure through cascade circuit. signal can be switched off by further super loading photosensitizer manganese porphyrin (MnPP). It is worth noting that not only improved reaction kinetics but also avoided leakage Compared traditional "signal-on" or "signal-off" readout, this strategy avoids false response background, thereby enhancing sensitivity accuracy biosensor. limit constructed sensor 0.3 fM in linear range from 1 10 nM. outstanding reproducibility, stability, provides promising platform disease

Язык: Английский

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Modular Engineering of the DNAzyme-Based Electrochemiluminescence Biosensor with the Nitrogen and Sulfur Codoped Carbon Dots as Near-Infrared Emitters for MicroRNA detection

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

DNAzyme-based biosensors remain at the forefront of microRNA (miRNA) analysis efforts. In this work, an electrochemiluminescence (ECL) biosensor technology integrating miRNA-initiated DNAzyme with a near-infrared ECL emission system was designed to detect miRNA. The through rational reconstitution Mg2+-specific 8-17 DNAzyme. We engineered strand incorporation blocker inhibit activity. formed duplex structure that prohibited hybridization one arm substrate strand, leading formation inactive structure. presence target miRNA, between miRNA and would induce breakage duplex, followed by active Thus, activity could be switched from OFF state into ON state. Moreover, nitrogen sulfur codoped carbon dots (NIR NS-CDs) were used as neoteric emitters, which not only possessed NIR reduce photochemical damage but also had low excitation potential range avoid side reaction. Therefore, combining modular engineering strategy NS-CDs constructed realize ultrasensitive miRNA-155 identification limit 58.5 aM. This DNAzyme-guided CD provides sensitive reliable method for detection, it has great in clinical diagnosis.

Язык: Английский

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Recent Advances and Future Prospects of Oxidative-Reduction Low-Triggering-Potential Electrochemiluminescence Strategy Based on Nanoparticle Luminophores

The Analyst, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Schematic diagram of the strategies used for LTP ECL.

Язык: Английский

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