Hydrogels mimicking the viscoelasticity of extracellular matrix for regenerative medicine: Design, application, and molecular mechanism DOI
Lichen Li, Shuhan Wang, You‐Tzung Chen

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155206 - 155206

Опубликована: Авг. 28, 2024

Язык: Английский

Dynamic Hydrogel‐Based Strategy for Traumatic Brain Injury Modeling and Therapy DOI Creative Commons
Xin He,

Meng Lei,

Xuewen Chen

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 1, 2025

ABSTRACT Traumatic brain injury (TBI) is one of the most traumatizing and poses serious health risks to people's bodies due its unique pathophysiological characteristics. The investigations on pathological mechanism valid interventions TBI have attracted widespread attention worldwide. With bio‐mimic mechanic cues, dynamic hydrogels with stiffness changes or reversible crosslinking been suggested construct in vitro disease models novel therapeutic agents for TBI. However, there a lack clarification currently reported their biomedical applications Our review starts introducing native mechanical characters then summarizes common chemical strategies dynamically tunable networks modeling therapy. Finally, we prospect future development TBI, providing new insights guidance tailored brain‐targeted biomaterials.

Язык: Английский

Процитировано

1
Frog‐Derived Neuroregenerative‐Peptide‐Reinforced Bioactive Hydrogels with Injectability, Thermosensitivity, and Enhanced Neurotrophic Function for Repairing Central Nervous Injuries DOI Creative Commons

Zhengang Sun,

Zhenjuan Sun,

Chenxi Du

и другие.

Small Structures, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

The clinical treatment of central nervous system (CNS) injuries presents significant challenges due to the inflammatory microenvironment (IME) induced by CNS injury, which inhibits spontaneous neuronal regeneration. Biomimetic biomaterial‐based IMEs for repair, facilitate reconstruction neural regeneration circuits, show promise. In this study, development novel bioactive peptide nanofibers (PNFs)/chitosan (CS)/VD11 (VDELWPPWLPC) hydrogels (named as PCV) is reported, created reinforcing composite PNFs/CS with a frog‐derived neuroregenerative (VD11). exhibit 3D porous structure, high thermosensitivity, good injectability, and enhanced neurotrophic properties, making them promising candidates repair. in vitro tests indicate that PCV can promote proliferation, migration, differentiation stem cells into neurons, well guide axonal growth. Additionally, they help mitigate responses reducing macrophage activation astrocyte while promoting neovascularization. vivo animal experimentsdemonstrate enhance blood supply damaged area migration colonization endogenous support Furthermore, reduce immune limit excessive significantly improving motor function recovery rats spinal cord injuries. these findings, it suggested provide strategy treating regulating IME.

Язык: Английский

Процитировано

0
Viscoelastic Mechanics: From Pathology and Cell Fate to Tissue Regeneration Biomaterial Development DOI
Xinyu Dai, Dan Wu, Ke Xu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Viscoelasticity is the mechanical feature of living tissues and cellular extracellular matrix (ECM) has been recognized as an essential biophysical cue in cell function fate regulation, tissue development homeostasis maintenance, disease progression. These findings provide new insights for biomaterials with comparable viscoelastic properties native ECMs matrix, displaying promising applications regeneration medicine. In this review, relationship between viscoelasticity functions (e.g., regeneration) physiological conditions progression aging, degenerative, fibrosis, tumor) pathological will be especially highlighted to figure out potential therapeutic target treatment inspiration related biomaterial development. Furthermore, understanding response ECM mechanism behind it are comprehensively summarized a pathophysiological basis design. The advances on defect repair also reviewed, suggesting significance matchable microenvironment regeneration. Although challenging, tunable that match show great promise. They could promote regeneration, treat degenerative diseases, support organoids artificial organs.

Язык: Английский

Процитировано

0
ROS-Triggered Biomimetic Hydrogel Soft Scaffold for Ischemic Stroke Repair DOI
Wen Zhang, Yang Liu,

Yu Wu

и другие.

Biomaterials, Год журнала: 2025, Номер 319, С. 123217 - 123217

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0
Bioactive hydrogel synergizes neuroprotection, macrophage polarization, and angiogenesis to improve repair of traumatic brain injury DOI Creative Commons

Yifan Hao,

Longbao Feng,

Huiling Liu

и другие.

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101335 - 101335

Опубликована: Ноя. 12, 2024

Traumatic brain injury (TBI) can lead to severe neurotrauma, leading long-term cognitive decline and even death. Massive neuronal loss excessive neuroinflammation are critical issues in the treatment of secondary TBI. To tackle these challenges, we developed a GelMA CSMA hydrogel loaded with Erythropoietin (EPO) Interleukin-4 (IL-4), named GC/I/E. By directly loading EPO, rapid neuroprotection angiogenesis were achieved. Meanwhile, by Mesoporous silica nanoparticles (MSNs) IL-4 (MSN@IL-4), sustained inflammation modulation during was attained.

Язык: Английский

Процитировано

2
Hydrogels mimicking the viscoelasticity of extracellular matrix for regenerative medicine: Design, application, and molecular mechanism DOI
Lichen Li, Shuhan Wang, You‐Tzung Chen

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155206 - 155206

Опубликована: Авг. 28, 2024

Язык: Английский

Процитировано

1