Gels,
Год журнала:
2025,
Номер
11(2), С. 123 - 123
Опубликована: Фев. 7, 2025
Recent
advancements
in
wound
dressing
materials
have
significantly
improved
acute
and
chronic
management
by
addressing
challenges
such
as
infection
control,
moisture
balance,
enhanced
healing.
Important
progress
has
been
made,
especially
with
hydrogels,
foams,
antimicrobial
for
creating
optimized
dressings.
Hydrogels
are
known
maintaining
optimal
levels,
while
foam
dressings
excellent
exudate
absorbents.
Meanwhile,
incorporates
various
agents
to
reduce
risks.
These
options
healing
time
focusing
on
customized
patient
needs.
Therefore,
this
review
highlights
the
newest
research
prototypes
applications,
emphasizing
their
particular
benefits
clinical
importance.
Innovations
stimuli-responsive
hydrogels
hybrid
bioengineered
composites
discussed
relation
properties,
including
responsiveness
pH,
temperature,
glucose,
or
enzymes
drug
delivery
precision.
Moreover,
ongoing
trials
included,
demonstrating
potential
of
emerging
solutions
be
soon
translated
from
laboratory
settings.
By
discussing
interdisciplinary
approaches
that
integrate
advanced
materials,
nanotechnology,
biological
insights,
work
provides
a
contemporary
framework
patient-centric,
efficient
care
strategies.
Porous
aromatic
frameworks
(PAFs)
are
a
fundamental
group
of
porous
materials
characterized
by
their
distinct
structural
features
and
large
surface
areas.
These
synthesized
from
building
units
linked
strong
carbon–carbon
bonds,
which
confer
exceptional
rigidity
long-term
stability.
PAFs
functionalities
may
arise
directly
the
intrinsic
chemistry
or
through
postmodification
motifs
using
well-defined
chemical
processes.
Compared
to
other
traditional
such
as
zeolites
metallic-organic
frameworks,
demonstrate
superior
stability
under
severe
treatments
due
robust
bonding.
Even
in
challenging
environments,
ease
functionalization
flexibility
specificity.
Research
on
has
significantly
expanded
accelerated
over
past
decade,
necessitating
comprehensive
overview
key
advancements
this
field.
This
review
provides
an
in-depth
analysis
recent
advances
synthesis,
functionalization,
dimensionality
PAFs,
along
with
distinctive
properties
wide-ranging
applications.
explores
innovative
methodologies
strategies
for
functionalizing
structures,
manipulation
tailor
specific
potential
Similarly,
application
areas,
including
batteries,
absorption,
sensors,
CO2
capture,
photo-/electrocatalytic
usages,
supercapacitors,
separation,
biomedical
discussed
detail,
highlighting
versatility
addressing
modern
scientific
industrial
challenges.
RSC Advances,
Год журнала:
2025,
Номер
15(7), С. 5117 - 5123
Опубликована: Янв. 1, 2025
Polyphenols
exhibit
strong
antioxidant,
and
anti-inflammatory
but
are
limited
by
chemical
instability
low
bioavailability.
To
address
these
challenges,
we
developed
polyphenol-amino
acid
conjugates
that
self-assemble
into
stable
nanospheres,
enhancing
their
stability
These
nanoparticles
demonstrate
significantly
improved
ROS
scavenging
efficiency
promote
cell
proliferation
in
vitro.
The
incorporation
of
amino
acids
enhances
biocompatibility
facilitates
effective
elimination.
offer
a
multifaceted
therapeutic
strategy
to
mitigate
oxidative
stress,
overcoming
traditional
antioxidant
limitations
through
advanced
nanotechnology.
This
approach
contributes
the
development
next-generation
wound
care
solutions
with
enhanced
efficacy
safety
profiles.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 290 - 290
Опубликована: Фев. 20, 2025
Objectives:
This
study
aimed
to
develop
hesperidin
solid
lipid
nanoparticles
(HESP-SLNs)
enhance
their
stability,
solubility,
and
sustained
release
for
wound
healing;
further
enhancement
was
achieved
through
prepared
nanostructured
carriers
(HESP-NLCs)
using
Tea
Tree
Oil
(TTO)
explore
synergistic
efficacy.
Methods:
A
factorial
design
of
24
trials
established
evaluate
the
influence
type
(X1),
conc
(%)
(X2),
surfactant
(X3),
sonication
amplitude
(X4)
HESP-SLNs
on
particle
size
(nm)
(Y1),
polydispersibility
index
(Y2),
zeta
potential
(Y3),
encapsulation
efficiency
(Y4).
The
optimized
formula
selected
utilizing
Design
Expert®
software
version
13,
which
additionally
enhanced
by
preparing
TTO-loaded
HESP-NLCs.
In
vitro
release,
Raman
spectroscopy,
transmission
electron
microscopy
were
carried
out
both
nanoparticles.
Cytotoxicity,
in
vivo
wound-healing
assessments,
skin
irritancy
tests
performed
performance
TTO-incorporated
HESP-NLCs
compared
HESP-SLNs.
Results:
demonstrated
PS
(280
±
1.35
nm),
ZP
(−39.4
0.92
mV),
PDI
(0.239
0.012),
EE%
(88.2
2.09%).
NLCs
Q6%
(95.14%)
vs.
(79.69%),
SLNs
showed
superior
antimicrobial
Both
exhibited
spherical
morphology
compatibility
between
HESP
excipients.
highest
closure
percentage,
supported
histological
analysis
inflammatory
biomarker
outcomes.
Cytotoxicity
evaluation
87%
cell
viability
untreated
HSF
cells,
test
confirmed
safety
NLCs.
Conclusions:
are
promising
candidates
exhibiting
capabilities,
making
them
a
therapeutic
option
cutaneous
management.
