Programmable DNA-based biomaterials for bone tissue engineering
Fundamental Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
GelMA Hydrogels Integrated With aptamer CH6‐Functionalized Tetrahedral DNA Nanostructures for Osteoporotic Mandibular Regeneration
Macromolecular Bioscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Osteoporotic
bone
regeneration
is
challenging
due
to
impaired
formation.
Tetrahedral
DNA
nanostructures
(TDN),
promising
nucleic
acid
nanomaterials,
have
garnered
attention
for
their
potential
in
osteoporotic
mandibular
owing
ability
enhance
cellular
activity
and
promote
osteogenic
differentiation.
Osteoblasts
play
a
critical
role
regeneration;
however,
intracellular
delivery
of
TDN
into
osteoblasts
remains
difficult.
In
this
study,
novel
osteoblast-targeted
CH6
aptamer-functionalized
(TDN-CH6)
aimed
develop
regeneration.
This
results
demonstrated
that
TDN-CH6
exhibits
superior
osteoblast
specificity
efficient
recruitment
fracture
sites.
Furthermore,
significantly
enhances
differentiation
compared
alone.
Notably,
Gelatin
Methacryloyl
(GelMA)
hydrogels
incorporating
shows
improved
biological
performance
are
favorable
regeneration,
suggesting
platform
represents
strategy
addressing
complex
defects.
Язык: Английский
Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Osteoporotic
bone
defects
are
challenging
to
repair
due
imbalances
in
resorption
and
formation,
coupled
with
insufficient
vascularization.
To
address
these
issues,
it
develops
a
trifunctional
hydrogel
(SF-ZIF@NA)
designed
selectively
inhibit
osteoclast
activity
enhance
vascularized
regeneration.
By
enzymatically
removing
sialic
acid,
SF-ZIF@NA
prevents
precursor
osteoclasts
(pOCs)
from
fusing
into
bone-resorbing
mature
(mOCs),
thereby
preserving
pOCs
their
anabolic
functions.
Additionally,
the
releases
Zinc
ion
(Zn2⁺)
response
acidic
conditions,
promoting
osteogenesis
angiogenesis.
In
vitro
results
confirmed
that
impedes
fusion,
enhances
platelet-derived
growth
factor-BB
(PDGF-BB
secretion
pOCs,
activates
FAK
(focal
adhesion
kinase)
signaling
pathway
stimulate
formation.
osteoporotic
defect
models,
accelerated
increased
density
These
findings
demonstrate
offers
targeted
multifunctional
strategy
for
regeneration
by
concurrently
modulating
Язык: Английский
Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations
Small Methods,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Tetrahedral
framework
nucleic
acids
(tFNAs)
are
renowned
for
their
controllable
self-assembly,
exceptional
programmability,
and
excellent
biocompatibility,
which
have
led
to
widespread
application
in
the
biomedical
field.
Beyond
these
features,
tFNAs
demonstrate
unique
chemical
biological
properties
including
high
cellular
uptake
efficiency,
structural
bio-stability,
tissue
permeability,
derived
from
distinctive
3D
structure.
To
date,
an
extensive
range
of
tFNA-based
nanostructures
intelligently
designed
developed
various
applications
such
as
drug
delivery,
gene
therapy,
biosensing,
engineering,
among
other
emerging
fields.
In
addition
role
delivery
systems,
also
possess
intrinsic
that
render
them
highly
effective
therapeutic
agents
treatment
complex
diseases,
arthritis,
neurodegenerative
disorders,
cardiovascular
diseases.
This
dual
functionality
significantly
enhances
utility
research,
presenting
valuable
opportunities
development
next-generation
medical
technologies
across
diverse
diagnostic
platforms.
Consequently,
this
review
comprehensively
introduces
latest
advancements
field,
with
a
focus
on
benefits
nanoplatforms,
inherent
capabilities
agents.
Furthermore,
current
limitations,
challenges,
future
perspectives
explored.
Язык: Английский