A Nano-Strategy for Advanced Triple-Negative Breast Cancer Therapy by Regulating Intratumoral Microbiota DOI
Jifan Gao, Lu Tang,

Cong Fu

и другие.

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Intratumoral microbiota have been identified as a component of the tumor microenvironment that regulates metastatic behavior tumors. They serve not only indicators pathology but also potential drug targets in cancer therapy. Herein, multifunctional nanoplatform (DD@FEL) is prepared by combining antibiotic doxycycline (DOXY) can combat intratumoral and chemotherapeutic doxorubicin (DOX) ergosterol-originated liposome. Specially, ergosterol utilized substitute for cholesterol liposomes to exert pharmacological activity. Mechanistically, DD@FEL leveraged DOXY inhibit metastasis based on regulation microbiota, which synergizes with effect DOX, eventually inhibiting progression triple-negative breast (TNBC). Verified both vitro vivo, effectively exerts cytotoxic TNBC cells, delays growth primary TNBC, attenuates development its lung metastasis, providing promising therapeutic strategy control orthotopic TNBC.

Язык: Английский

Conjugated polymer of Multi-arm-PEG and dimethylsiloxane (CPMD) for the effective transdermal delivery of deoxycholic acid for fat reduction DOI Creative Commons
Hwajun Jeong, H.K. Kim,

H. Kim

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159405 - 159405

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment DOI
Yue Yin, Lu Tang,

Yuqi Cao

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 678 - 695

Опубликована: Янв. 24, 2025

Язык: Английский

Процитировано

1
Bacterial outer membrane vesicles-clothed nanoparticles delivered by live macrophages for potentiating antitumor photoimmunotherapy DOI

Cong Fu,

Lu Tang,

Yuqi Cao

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 499, С. 156420 - 156420

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

4
A Nano-Strategy for Advanced Triple-Negative Breast Cancer Therapy by Regulating Intratumoral Microbiota DOI
Jifan Gao, Lu Tang,

Cong Fu

и другие.

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Intratumoral microbiota have been identified as a component of the tumor microenvironment that regulates metastatic behavior tumors. They serve not only indicators pathology but also potential drug targets in cancer therapy. Herein, multifunctional nanoplatform (DD@FEL) is prepared by combining antibiotic doxycycline (DOXY) can combat intratumoral and chemotherapeutic doxorubicin (DOX) ergosterol-originated liposome. Specially, ergosterol utilized substitute for cholesterol liposomes to exert pharmacological activity. Mechanistically, DD@FEL leveraged DOXY inhibit metastasis based on regulation microbiota, which synergizes with effect DOX, eventually inhibiting progression triple-negative breast (TNBC). Verified both vitro vivo, effectively exerts cytotoxic TNBC cells, delays growth primary TNBC, attenuates development its lung metastasis, providing promising therapeutic strategy control orthotopic TNBC.

Язык: Английский

Процитировано

0