Protocatechuic acid grafted chitosan/oxidized glucomannan hydrogel with antimicrobial and anti-inflammatory effects for enhancing wound repair

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136514 - 136514

Опубликована: Окт. 14, 2024

Язык: Английский

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In situ photocrosslinkable hydrogel treats radiation-induced skin injury by ROS elimination and inflammation regulation

Biomaterials, Год журнала: 2024, Номер 314, С. 122891 - 122891

Опубликована: Окт. 12, 2024

Язык: Английский

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Zinc Cerium Peroxide Antibacterial Agent with Acid-Activated Cascade Multienzymatic Activities

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Recently, metal peroxides with the ability to self-supply H2O2 have been intensively used in antibacterial and cancer therapy. However, performances are unsatisfactory due low efficiency of peroxide-mediated Fenton-like reaction. In this work, a novel zinc cerium bimetallic peroxide (CeZnOx) has first reported, which possesses acid-activated POD-like, OXD-like, CAT-like multienzymatic activities for efficiently bacterial inhibition. Specifically, CeZnOx self-supplying under weakly acidic conditions subsequently catalyzes production reactive oxygen species (ROS) through synergistically enhanced POD-like OXD-like activity. They can also exhibit activity catalyze excessive into O2 play an anti-inflammatory role normal pH conditions. The cascade inhibit growth alleviate hypoxia, improving microenvironment at wound site. As expected, exhibits superior effect on Staphylococcus aureus Escherichia coli. Therefore, CeZnOx-mediated offer simple promising strategy efficient treatment infections.

Язык: Английский

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Material Design, Fabrication Strategies, and the Development of Multifunctional Hydrogel Composites Dressings for Skin Wound Management

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

The skin is fragile, making it very vulnerable to damage and injury. Untreated wounds can pose a serious threat human health. Three-dimensional polymer network hydrogels have broad application prospects in wound dressings due their unique properties structure. therapeutic effect of traditional limited, while multifunctional composite show greater potential. Multifunctional regulate moisture through formula adjustment. Moreover, be combined with bioactive ingredients improve performance healing applications. Stimulus-responsive respond specifically the environment meet needs different stages. This review summarizes material types, structure, properties, design considerations, formulation strategies for hydrogel used healing. We discuss various types recently developed dressings, highlights importance tailoring physicochemical addresses potential challenges preparing dressings.

Язык: Английский

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A sustained H2S-releasing nanocellulose-based hydrogel with anti-inflammatory and antibacterial properties for promoting infected wound healing

Carbohydrate Polymers, Год журнала: 2025, Номер 355, С. 123424 - 123424

Опубликована: Фев. 20, 2025

Язык: Английский

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Progress in Advanced Composite Hydrogel Dressings: Innovative Materials and Designs for the Treatment of Chronic Wounds

ChemistrySelect, Год журнала: 2025, Номер 10(8)

Опубликована: Фев. 1, 2025

Abstract Chronic wounds, as a kind of long‐term disease that is difficult to cure, are challenged in healthcare, placing substantial physical, emotional, and economic burdens on patients society. Effective treatment chronic wounds essential for improving patient quality life, reducing healthcare costs, alleviating the strain medical resources. Hydrogel materials have emerged promising candidates wound due their exceptional adaptability environments ability deliver various therapeutic agents, effectively promoting healing wounds. However, wide array available with diverse functionalities presents challenge selecting most appropriate components synthesizing hydrogel dressings. This review summarizes common materials, including properties, cross‐linking methods, applications. Additionally, it systematically categorizes different elucidating action mechanisms effects. Furthermore, this work offers guidance material selection dressing design based characteristics Finally, challenges future perspectives composite hydrogels field dressings discussed. provides readers comprehensive understanding reliable basis synthesize ideal

Язык: Английский

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Construction of CeO2/Ti3C2Tx heterojunction with antibacterial and antioxidant capabilities for diabetic wound healing

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 689, С. 137247 - 137247

Опубликована: Март 4, 2025

Язык: Английский

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Immunomodulatory All-Natural Kelp Decellularized Scaffold Prepared Using Deep Eutectic Solvent with Angiogenic Properties for Accelerating Diabetic Wound Healing

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Excessive oxidative stress, chronic inflammation, and impaired vascularization are the main barriers to diabetic wound repair. A decellularized extracellular matrix (dECM) with a native ECM structure is promising biomaterial candidate for healing. However, traditional decellularization process (reagents) can diminish structural stability, mechanical properties, bioactive components of dECM. To address these issues, we developed an intrinsically kelp scaffold (Im-Gly2) using natural gentle deep eutectic solvents (DES) accelerating Im-Gly2 had stable porous 3D (80.7 μm) suitable which could support cell growth, proliferation, migration. Due retention fucoidan, polyphenols (735.3 μg/g), flavonoids, demonstrated intrinsic antioxidant immunomodulatory effects. It effectively reduced reactive oxygen species (ROS) production in RAW264.7 macrophages promoted their differentiation into M2 phenotype. Notably, tube formation through paracrine mechanisms by inducing expression transforming proliferative cytokines from macrophage. In vivo, accelerated healing wounds alleviating angiogenesis, granulation tissue formation, collagen deposition, re-epithelialization. Taken together, our study provides novel strategy fabricating dECM without cross-linking exogenous substances

Язык: Английский

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Hyaluronic acid-based ε-polylysine/polyurethane asymmetric sponge for enhanced wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136395 - 136395

Опубликована: Окт. 9, 2024

Язык: Английский

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Chitosan and gelatin based sprayable hydrogels incorporating photothermal and long-acting antibiotic sterilization for infected wound management with shape adaptability

Carbohydrate Polymers, Год журнала: 2024, Номер 350, С. 123046 - 123046

Опубликована: Ноя. 20, 2024

Язык: Английский

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