Prodigiosin Loaded SN‐PB@PG NPs‐Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds DOI Open Access

Wu Zhou,

Chang Li,

Changling Li

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

Abstract Healing of infected chronic wounds faces dual challenges: persistent inflammation and impaired angiogenesis. To address these, SN‐PB@PG nanocomplexes were prepared by hybridisation nitroprusside (SNP) with Prussian blue (SN‐PB NPs) loaded prodigiosin (PG). Under near‐infrared (NIR) irradiation, SN‐PB NPs generated mild hyperthermia, facilitating the release nitric oxide (NO) PG to combat bacterial biofilms multidrug‐resistant pathogens. The in vivo assay using diabetic demonstrated that NIR reduced wound area 10.6% 11th day, which is superior control group (29.6%). In flap transplantation experiments, data showed only have a necrobiosis 3.8% flaps on 8th 31.3% group. Additionally, NO promoted vascular regeneration up‐regulating endothelial growth factor (VEGF) platelet cell adhesion molecule‐1 (CD31), regenerated sarcomeric tissue down‐regulating MMP‐9. results indicated combination gas photothermal therapy exerted combined antibacterial healing effect. Compared traditional clinical methods such as surgical debridement hyperbaric oxygen therapy, this new strategy efficiently addresses issues infection healing, convenient for application.

Язык: Английский

A Dual‐Catalysis Mode for ROS Regulation to Accelerate Biointegration of Implants in Infected Diabetic Wound DOI Open Access

Huihui Xie,

Lan Zhang, Jun Chen

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Abstract Pathological microenvironment of diabetes including hyperglycemia, excessive reactive oxygen species (ROS), and accumulation advanced glycation end products leads to high risk infection persistent inflammatory reaction, retarding biointegration implants. To address this issue, a dual‐catalysis system consisting Na 2 TiO 3 nanotubes with CeO nanodots polydopamine (PDA) cover is constructed on Ti implant manipulate ROS generation scavenging for antibiosis tissue regeneration. form heterojunction, in which vacancies (VOs) contribute the separation electron‐hole pairs under near‐infrared light (NIR) irradiation. In NIR mode, photocatalysis‐induced photothermal‐induced hyperthermia by ‐CeO heterojunction PDA synergistically kill bacteria efficiently. non‐NIR show excellent superoxide dismutase (SOD) catalases (CAT) like enzyme activities, they catalyze (e.g., ·O − H O ) thoroughly into benign O, relieving oxidative stress accelerating M2 macrophage phenotype. It helps biofunctional recovery endothelial cells fibroblasts, promoting regeneration around implants diabetic models. This work proposes promising approach manipulating treat regulate thereby improving performance microenvironment.

Язык: Английский

Процитировано

0
Prodigiosin Loaded SN‐PB@PG NPs‐Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds DOI Open Access

Wu Zhou,

Chang Li,

Changling Li

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

Abstract Healing of infected chronic wounds faces dual challenges: persistent inflammation and impaired angiogenesis. To address these, SN‐PB@PG nanocomplexes were prepared by hybridisation nitroprusside (SNP) with Prussian blue (SN‐PB NPs) loaded prodigiosin (PG). Under near‐infrared (NIR) irradiation, SN‐PB NPs generated mild hyperthermia, facilitating the release nitric oxide (NO) PG to combat bacterial biofilms multidrug‐resistant pathogens. The in vivo assay using diabetic demonstrated that NIR reduced wound area 10.6% 11th day, which is superior control group (29.6%). In flap transplantation experiments, data showed only have a necrobiosis 3.8% flaps on 8th 31.3% group. Additionally, NO promoted vascular regeneration up‐regulating endothelial growth factor (VEGF) platelet cell adhesion molecule‐1 (CD31), regenerated sarcomeric tissue down‐regulating MMP‐9. results indicated combination gas photothermal therapy exerted combined antibacterial healing effect. Compared traditional clinical methods such as surgical debridement hyperbaric oxygen therapy, this new strategy efficiently addresses issues infection healing, convenient for application.

Язык: Английский

Процитировано

0