Design and biomedical application of Cr3+-doped gallate near-infrared persistent luminescence nanoprobes

Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159183 - 159183

Опубликована: Янв. 5, 2025

Язык: Английский

---

Injectable melatonin carbon dot composite hydrogel enhances anti-inflammatory and tenogenic differentiation of tendon-derived stem cells for minimally invasive treatment of Achilles tendinopathy

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160720 - 160720

Опубликована: Фев. 1, 2025

Язык: Английский

---

Recent applications of stimulus-responsive smart hydrogels for osteoarthritis therapy

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Фев. 17, 2025

Osteoarthritis is one of the most common degenerative joint diseases, which seriously affects life middle-aged and elderly people. Traditional treatments such as surgical treatment systemic medication, often do not achieve expected or optimal results, leads to severe trauma a variety side effects. Therefore, there an urgent need develop novel therapeutic options overcome these problems. Hydrogels are widely used in biomedical tissue repairing platform for loading drugs, proteins stem cells. In recent years, smart-responsive hydrogels have achieved excellent results drug delivery systems osteoarthritis. This review focuses on advances endogenous stimuli (including enzymes, pH, reactive oxygen species temperature, etc.) responsive exogenous light, shear, ultrasound magnetism, osteoarthritis treatment. Finally, current limitations application future prospects smart summarized.

Язык: Английский

---

New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research

Gels, Год журнала: 2025, Номер 11(2), С. 136 - 136

Опубликована: Фев. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Язык: Английский

---

Nanocomposite hydrogel with multiple metal ions coupling for effective treatment of bacteria infected wound via cascade catalysis and tissue regeneration

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161783 - 161783

Опубликована: Март 1, 2025

Язык: Английский

---

Injectable Hydrogel Technologies for Bone Disease Treatment

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Injectable hydrogels represent a highly promising approach for localized drug delivery systems (DDSs) in the management of bone-related conditions such as osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma. Their appeal lies their biocompatibility, adjustable mechanical properties, capacity to respond external stimuli, including pH, temperature, light, redox potential, ionic strength, enzymatic activity. These features enable enhanced targeted bioactive agents. This mini-review evaluates synthesis injectable well recent advancements treating range bone disorders, focusing on mechanisms sustained DDSs delivering drugs, nanoparticles, growth factors, cells (e.g., stem cells). Moreover, it highlights clinical studies disease treatment. Additionally, emphasizes potential synergy between hydrogel-based point-of-care technologies, which are anticipated play pivotal role future therapies. have transform treatment by facilitating precise, sustained, minimally invasive therapeutic delivery. Nevertheless, significant challenges, long-term scalability, reproducibility, precise regulation release kinetics, must be addressed unlock fully. Addressing these challenges will not only advance therapy but also open new avenues regenerative medicine personalized healthcare.

Язык: Английский

---

Background-free and dual-signal output intelligent hydrogel nanosensor for sensitive detection of catalase in serum

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162593 - 162593

Опубликована: Апрель 1, 2025

Язык: Английский

---

Chitosan-based dihydromyricetin composite hydrogel demonstrating sustained release and exceptional antibacterial activity

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139128 - 139128

Опубликована: Дек. 1, 2024

Язык: Английский

---