“Integrated Stacked” Design “Nanobullet” for High Photothermal Conversion in Dual-Mode Lateral Flow Immunoassay
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Salmonella
enterica
serovar
typhimurium
(S.
typhimurium),
a
prevalent
foodborne
bacterium,
necessitates
creating
sensitive
and
rapid
detection
methods
for
food
safety,
with
lateral
flow
immunoassays
(LFIAs)
using
nanomaterials
as
signal
tracers
being
particularly
effective.
Enhancements
in
performance
sensitivity
are
not
restricted
to
the
material
alone,
we
propose
an
"integrated
stacked"
concept,
which
combines
amorphous
active
sites,
hollow
morphology
enhanced
reflection,
symmetric
structure
strong
absorption
resonance.
This
approach
leads
significant
photothermal
enhancement
(η
=
60.66%)
is
supported
by
finite
element
analysis
(|E|max2
3100).
A
"nanobullet"
(RuTe2)
was
created,
featuring
vivid
colorimetric
enhancing
range,
large
specific
surface
area
(≈6:1)
improved
antibody
binding,
excellent
properties
facilitating
dual-mode
transduction.
After
5
min
of
limits
RuTe2-LFIA
S.
after
12
were
2398.83
cfu
mL–1
(colorimetric)
977.23
(photothermal),
36.14
88.72
times
lower
than
values
AuNPs-LFIA
(86696.19
mL–1).
The
superior
suggests
potential
advancements
materials
point-of-care
testing.
Язык: Английский
Biomimetic CuCoO2 nanosheets reinforced with self-assembling peptide nanofibers for tumor photothermal therapy
RSC Advances,
Год журнала:
2024,
Номер
14(53), С. 39163 - 39172
Опубликована: Янв. 1, 2024
The
flexible
design
and
unique
physical
chemical
properties
of
self-assembled
peptides
have
shown
great
potential
for
applications
in
the
fields
materials
science,
life
environmental
science.
Peptide
nanofibers
(PNFs),
as
a
kind
bioactive
nanomaterials,
possess
excellent
biocompatibility,
designability,
multifaceted
functionalizability.
In
this
work,
we
describe
PNFs
that
by
peptide
molecules
carriers
bimetallic
nanosheets
(BMNS),
leading
to
development
hybrid
BMNS-PNFs,
with
properties.
BMNS-PNFs
exhibit
photothermal
conversion
efficiency
(PCE)
up
31.57%,
can
be
used
nanoplatform
therapy
(PTT)
lung
tumour
cells.
Through
results,
it
is
reduce
cytotoxicity
cancer
cell
killing
effects,
rates
more
than
95%
90%
cells
HCC2279
PC9,
respectively.
Finally,
comprehensive
PTT
performance
analysed
Ranking
Efficiency
Performance
(REP),
REP
value
calculated
0.741.
sequences
assemble
into
study
are
instructive
functional
structural
modulation
molecular
self-assembly,
constructed
bimetallic-biomolecular
provide
strategy
medical
bioengineering.
Язык: Английский