Defect Engineering of Layered Double Hydroxide Nanosheets as Inorganic Photosensitizers for NIR‐II Photodynamic Hypertrophic Cardiomyopathy Therapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Abstract Hypertrophic obstructive cardiomyopathy (HOCM) is the most common hereditary cardiovascular disease, whereas its current treatment strategies present many postoperative complications and contraindications. Photodynamic therapy (PDT) expected to be a new strategy for HOCM due minimal side effects, exceptional spatiotemporal precision low invasiveness. However, developing photosensitizer (PSs) that can activated by long‐wavelength light with high reactive oxygen species (ROS) generation efficiency achieve ventricular septal ablation remains great challenge. Herein, defect‐rich CoZnW‐layered double hydroxide (DR‐CoZnW‐LDH) first reported as highly active PS NIR‐II photodynamic therapy. Hydrothermal‐synthesized CoZnW‐LDH are etched acid obtain DR‐CoZnW‐LDH nanosheets, which exhibit superior ROS activity than of pristine under 1270 nm laser irradiation. Studies reveal thickness interventricular septum in HCM rats closes normal level after bovine serum albumin‐modified DR‐CoZnW‐LDH. Echocardiographic assessments indicate PDT intervention markedly improves left outflow tract obstruction cardiac diastolic function rats. Furthermore, mechanism studies show PDT‐derived significantly activates Piezo2 ion channel, promotes Piezo2‐dependent Ca 2+ accumulation (increased fourfold), leading effective hypertrophic myocardium reduction gradient.

Язык: Английский

In situ formation of heterojunction of thiophene-based metal–organic frameworks with carbon dots for efficient overall water splitting and supercapacitor applications

Journal of Materials Chemistry A, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The interface engineering-based 400N-CDs/FeNi-TDC electrocatalytic material is important for the construction of efficient self-powered OWS to produce renewable energy.

Язык: Английский