Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

The year 2024 marks the 50th anniversary of discovery surface-enhanced Raman spectroscopy (SERS). Over recent years, SERS has experienced rapid development and became a critical tool in biomedicine with its unparalleled sensitivity molecular specificity. This review summarizes advancements challenges substrates, nanotags, instrumentation, spectral analysis for biomedical applications. We highlight key developments colloidal solid an emphasis on surface chemistry, hotspot design, 3D hydrogel plasmonic architectures. Additionally, we introduce innovations including those interior gaps, orthogonal reporters, near-infrared-II-responsive properties, along biomimetic coatings. Emerging technologies such as optical tweezers, nanopores, wearable sensors have expanded capabilities single-cell single-molecule analysis. Advances analysis, signal digitalization, denoising, deep learning algorithms, improved quantification complex biological data. Finally, this discusses applications nucleic acid detection, protein characterization, metabolite monitoring, vivo spectroscopy, emphasizing potential liquid biopsy, metabolic phenotyping, extracellular vesicle diagnostics. concludes perspective clinical translation SERS, addressing commercialization potentials tissue sensing imaging.

Язык: Английский

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Resonance SERS probe based on the bifunctional molecule IR808 combined with SA test strips for highly sensitive detection of monkeypox virus

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 331, С. 125761 - 125761

Опубликована: Янв. 17, 2025

Язык: Английский

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Applications of Magnetic Nanocomposites and Their Role in Advancing Lateral Flow Assays

ChemistrySelect, Год журнала: 2025, Номер 10(7)

Опубликована: Фев. 1, 2025

Abstract This article explores the wide‐ranging applications of magnetic nanocomposites and their critical role in advancing lateral flow assays (LFAs) as diagnostic tools. We begin by reviewing a diverse array nanomaterials, including plasmonic, polymer, carbon, silica‐based nanocomposites, well notable examples such CoFe₂O₄, quantum dots, lipid‐based nanoparticles, hydrogels, metal–organic frameworks (MOFs), superparamagnetic iron oxide nanoparticles (SPIONs), gold nanorods. Each type nanocomposite is examined for its unique properties significant potential enhancing sensitivity, stability, multifunctionality. These are used across various sectors, medical diagnostics, environmental monitoring, imaging technology, where they contribute to improved signal strength, binding affinity, biocompatibility. The focuses specifically on application LFAs. rely nanoparticles’ interactions with target molecules achieve detection, providing promising platform point‐of‐care diagnostics. integration enhances detection limits, improves precision, reduces response times, making them an invaluable component rapid tests. By embedding into LFAs, researchers clinicians can more reliable accurate results, facilitating early diagnosis ultimately improving patient outcomes. Their LFAs demonstrates applications, from disease real‐time suggesting transformative impact diagnostics beyond.

Язык: Английский

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Magnetic nanoprobe-enabled lateral flow assays in the applications of food safety and in vitro diagnostic

Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216588 - 216588

Опубликована: Март 9, 2025

Язык: Английский

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Preparation of magnetic Fe3O4 composite Cu-MOFs and their removal of perrhenate ions

Journal of Solid State Chemistry, Год журнала: 2025, Номер unknown, С. 125390 - 125390

Опубликована: Апрель 1, 2025

Язык: Английский

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