A multirisk-rescued biomimetic nanozyme against periodontitis via inflammation targeting and microenvironment reprogramming
Chemical Engineering Journal,
Год журнала:
2025,
Номер
506, С. 160119 - 160119
Опубликована: Янв. 1, 2025
Язык: Английский
A Multirisk-Rescued Biomimetic Nanozyme Against Periodontitis Via Inflammation Targeting and Microenvironment Reprogramming
Опубликована: Янв. 1, 2025
Periodontitis
is
an
intractable
chronic
inflammatory
disease
characterized
by
excessive
proinflammatory
factors
production
and
reactive
oxygen
species
(ROS)
accumulation.
Nanodrugs
have
made
significant
contributions
in
the
biomedical
field
but
fall
short
as
periodontitis
therapeutics
because
of
their
singular
effects,
low
retention
rates,
poor
specificity,
insufficient
biocompatibility.
Herein,
we
report
a
functionalized
periodontal
ligament
stem
cell
(PDLSC)
membrane-camouflaged
MnO2
nanoplatform
(MnO2@hPM)
to
target
reprogram
microenvironment
periodontitis.
PDLSC-affinity
biological
molecules
hypoxia-educated
proteins
on
membrane
coating
endow
MnO2@hPM
with
capacities
actively
PDLSCs
under
environment,
concurrently
neutralize
various
factors,
scavenge
overburdened
ROS.
The
synergistic
effects
inflammation
inhibition
ROS
elimination
mitigate
mitochondrial
dysfunction,
improve
metabolic
disturbance,
restore
osteogenic
potential
inflammation-impaired
PDLSCs.
In
vivo,
effectively
accumulates
at
sites,
significantly
ameliorates
inflammation,
alleviates
bone
loss
artificial
periodontitis,
showing
optimized
therapeutic
performance
for
tissue
reconstruction.
This
multirisk-rescuing
biomimetic
nanozyme
good
biocompatibility
exhibits
inflammation-targeting
ability
benefits
against
highlighting
its
advanced
therapy
other
diseases.
Язык: Английский
Recent advances in nanomaterials and their mechanisms for infected wounds management
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101553 - 101553
Опубликована: Фев. 5, 2025
Wounds
infected
by
bacteria
pose
a
considerable
challenge
in
the
field
of
healthcare,
particularly
with
increasing
prevalence
antibiotic-resistant
pathogens.
Traditional
antibiotics
often
fail
to
achieve
effective
results
due
limited
penetration,
resistance
development,
and
inadequate
local
concentration
at
wound
sites.
These
limitations
necessitate
exploration
alternative
strategies
that
can
overcome
drawbacks
conventional
therapies.
Nanomaterials
have
emerged
as
promising
solution
for
tackling
bacterial
infections
facilitating
healing,
thanks
their
distinct
physicochemical
characteristics
multifunctional
capabilities.
This
review
highlights
latest
developments
nanomaterials
demonstrated
enhanced
antibacterial
efficacy
improved
healing
outcomes.
The
mechanisms
are
varied,
including
ion
release,
chemodynamic
therapy,
photothermal/photodynamic
electrostatic
interactions,
delivery
drugs,
which
not
only
combat
but
also
address
challenges
posed
biofilms
antibiotic
resistance.
Furthermore,
these
create
an
optimal
environment
tissue
regeneration,
promoting
faster
closure.
By
leveraging
unique
attributes
nanomaterials,
there
is
significant
opportunity
revolutionize
management
wounds
markedly
improve
patient
Язык: Английский
A Porphyrin-Based Metal–Organic Framework Nanozyme with Superior Peroxidase-like Activity for Combating Antibacterial Infections and Promoting Wound Healing
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
As
an
antibacterial
agent,
H2O2
is
widely
used
to
combat
pathogenic
bacterial
infections
clinically.
To
mitigate
potential
side
effects
associated
with
a
high
dosage
of
H2O2,
it
pivotal
improve
its
efficacy.
Herein,
nanoscale
porphyrin-based
mesoporous
metal-organic
framework
(MOF)
nanozyme,
Nano-PCN-222(Fe),
was
readily
prepared
by
one
pot.
Nano-PCN-222(Fe)
shows
striking
peroxidase
(POD)-like
activity
comparable
that
natural
enzyme
horse
radish
peroxidase.
Such
POD-like
nanozyme
primarily
attributed
both
the
monodispersion
and
accessibility
single-atom
catalytic
sites
Fe
within
framework.
consequence
ability
effectively
catalyze
decomposition
into
more
toxic
hydroxyl
radicals,
excellent
against
Gram-negative
(Escherichia
coli)
Gram-positive
(Staphylococcus
aureus)
bacteria
assistance
H2O2.
Remarkably,
only
10
mM
sufficient
fully
kill
E.
coli
S.
aureus
in
presence
(10
ppm),
which
significantly
lower
than
actual
clinical
disinfection
(166-1000
mM).
Moreover,
could
accelerate
infected
wound
healing
due
superior
antimicrobial
activity.
Additionally,
no
appreciable
biotoxicity
observed
even
though
up
30
ppm.
Язык: Английский
ROS-related nanoparticles for the management of Alzheimer’s disease: Wielding the double-edged sword
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 161784 - 161784
Опубликована: Март 1, 2025
Язык: Английский
IR820 Sensitized Ceria Nanozyme via PDA Bridging for Multifaceted Antibacterial Wound Healing Therapy
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Nanozymes
with
peroxidase
(POD)-like
activity
hold
significant
potential
for
addressing
antibiotic-resistant
bacterial
infections.
However,
their
catalytic
efficiency
and
therapeutic
efficacy
need
further
improvement
to
broaden
clinical
applications.
A
key
challenge
is
achieving
efficient
energy
transfer
from
photosensitizing
molecules
nanozymes,
which
critical
enhancing
performance.
In
this
study,
a
universal
strategy
developed
bridge
nanozymes
molecules,
designing
photoactivated
called
IR820/PDA@mCeO2
(IR/P@Ce).
By
integrating
IR820,
photosensitizer,
mesoporous
ceria
(mCeO2),
it
facilitates
electron
through
polydopamine
(PDA)
resulting
in
enhanced
POD-like
performance
reactive
oxygen
species
production.
Additionally,
PDA
stabilized
the
nanozyme,
improved
photothermal
therapy,
photodynamic
therapy
under
near-infrared
light
exposure,
amplifying
destruction.
This
multifunctional
nanozyme
demonstrated
strong
antibacterial
against
both
Gram-positive
(Staphylococcus
aureus)
Gram-negative
(Escherichia
coli)
bacteria.
Moreover,
its
synergistic
approach
not
only
facilitated
eradication
but
also
accelerated
wound
healing
vivo,
making
promising
alternative
managing
infections
promoting
tissue
regeneration.
Язык: Английский
Nanozymes in biomedicine: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2007 to 2024)
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142798 - 142798
Опубликована: Апрель 1, 2025
Язык: Английский
A Multifunctional Hydrogel for Infected Chronic Wounds Management: Integrated pH Sensing, Photothermal Therapy, and Ion Release
Journal of Applied Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
ABSTRACT
Chronic
wound
healing
is
often
compromised
by
bacterial
infection,
and
pH
changes
strongly
correlate
with
infection.
Therefore,
the
development
of
dressings
capable
real‐time
monitoring,
antimicrobial
activity,
tissue
repair
crucial
for
effective
management
infected
chronic
wounds.
This
study
reports
a
novel
multifunctional
composite
hydrogel
(GM‐C‐mBG@P)
synthesized
incorporating
microwave‐synthesized
carbon
quantum
dots
(CQDs)
polydopamine‐modified
mesoporous
bioactive
glass
nanoparticles
(mBG@P)
into
modified
gelatin
methacryloyl
(GelMA).
The
incorporated
polydopamine
(PDA)
confers
excellent
photothermal
properties
to
hydrogel,
enabling
activity.
Under
360
nm
UV
excitation,
fluorescence
intensity
CQDs
in
GM‐C‐mBG@P
exhibits
strong
linear
correlation
pH,
monitoring.
Furthermore,
mBG@P
can
gradually
dissolve
calcium,
silicon,
boron,
other
functional
ions
enhance
bioactivity
functionality
accelerate
healing.
These
findings
suggest
that
has
potential
serve
as
promising
dressing
treatment
Язык: Английский