Brain‐Derived Extracellular Matrix (B‐ECM)‐Based Aligned Electrospun Fibers for Sciatic Nerve Regeneration
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Nerve
injuries
pose
numerous
challenges
and
adversely
affect
the
quality-of-life
(QOL)
of
patients.
Artificial
nerve
guidance
conduits
(aNGCs)
are
fabricated
using
natural
synthetic
polymers
alongside
bioactive
cues.
The
objective
this
study
is
to
simultaneously
leverage
biophysical
biochemical
cues
develop
aNGCs.
fabricates
core/shell
aligned
electrospun
fibers
polycaprolactone
(PCL)
brain-derived
extracellular
matrix/gelatin
(B-ECM/Gel)
as
core
shell
components,
respectively,
then
integrates
them
with
PCL/Gel-based
tubular
scaffolds
fabricate
H&E
staining
DNA
quantification
B-ECM
manifest
successful
removal
cell
nuclei
preserved
(e.g.,
glycosaminoglycans,
proteins,
etc.),
which
influenced
migration
neurite
outgrowth
Schwann
cells
Pheochromocytoma
(PC12)
in
a
dose-dependent
manner
both
solubilized
form
vitro.
PCL/Gel
(layer
thickness
=
400-500
µm)
enhanced
transport
nutrients,
while
suppressed
accumulation
inflammatory
at
scaffold-tissue
interface.
In
vivo
evaluation
aNGCs
rat
sciatic
defect
model
(length
1
cm)
exhibit
host
infiltration
along
alignment
direction
fibers.
regeneration
higher
containing
B-ECM.
B-ECM-based
may
have
broad
implications
for
neural
engineering
potentially
other
bio-related
disciplines.
Язык: Английский
Novel Tissue Engineering Scaffolds in the Treatment of Spinal Cord Injury—A Bibliometric Study
Bioengineering,
Год журнала:
2025,
Номер
12(4), С. 347 - 347
Опубликована: Март 28, 2025
Objective:
Because
of
the
evolving
nature
tissue
engineering
scaffolds
in
treatment
spinal
cord
injury
(SCI),
current
study
was
carried
out
to
evaluate
research
productivity
SCI.
Methods:
Studies
published
from
2000
2025
were
retrieved
Web
Science
core
collection
with
topics
and
scaffolds.
The
data
analyzed
visualized
using
VOSviewer
network
analysis
software.
Results:
Among
1542
articles
analyzed,
annual
publications
surged
2019,
stabilizing
thereafter.
U.S.,
China,
Canada
led
productivity,
Northwestern
University
Biomaterials
journal
being
top
contributors.
Keyword
revealed
hotspots
such
as
functional
recovery,
axonal
regeneration,
stem
cells,
hydrogels.
Notably,
hydrogels
embedded
genetically
engineered
cells
emerged
a
pivotal
trend,
reflecting
shift
toward
biomimetic
combinatorial
therapies.
Collaboration
networks
highlighted
intensified
partnerships
between
Chinese
North
American
institutions,
signaling
global
interdisciplinary
efforts.
Conclusions:
This
provides
first
bibliometric
roadmap
for
SCI,
identifying
key
trends,
influential
entities,
underexplored
areas.
rise
international
collaborations
underscores
opportunities
targeted
research.
These
findings
guide
researchers
prioritizing
high-impact
journals,
fostering
partnerships,
advancing
novel
scaffold
designs
bridge
translational
gaps
SCI
treatment.
Язык: Английский